Anaphylatoxins and infectious and non-infectious inflammatory diseases

Critical protective role of mast cells in a model of acute septic peritonitis

1996 • 942 citations

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

1995 • 626 citations

Systemic Lupus Erythematosus, Complement Deficiency, and Apoptosis

2001 • 525 citations

Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity.

1995 • 496 citations

The Human Complement System in Health and Disease

1998 • 474 citations

C5a-induced expression of P-selectin in endothelial cells.

1994 • 470 citations

C5A Anaphylatoxin and Its Seven Transmembrane-Segment Receptor

1994 • 418 citations

Protective effects of C5a blockade in sepsis

1999 • 403 citations

Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

2000 • 387 citations

Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma

1997 • 373 citations

Selective Suppression of Interleukin-12 Induction after Macrophage Receptor Ligation

1997 • 363 citations

A role for the C3a anaphylatoxin receptor in the effector phase of asthma

2000 • 356 citations

The C5a chemoattractant receptor mediates mucosal defence to infection

1996 • 345 citations

Neurogenic Amplification of Immune Complex Inflammation

1996 • 334 citations

C3a and C5a Stimulate Chemotaxis of Human Mast Cells

1997 • 326 citations

Impaired mast cell-dependent natural immunity in complement C3-deficient mice

1997 • 283 citations

Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6

2000 • 240 citations

Complement Peptides C3a- and C5a-Induced Mediator Release from Dissociated Human Skin Mast Cells

1994 • 221 citations

Role of C5a in Multiorgan Failure During Sepsis

2001 • 216 citations

The Human Complement System in Health and Disease

1998 • 213 citations

Gram-negative sepsis: a dilemma of modern medicine

1993 • 207 citations

Expression of the Complement Anaphylatoxin C3a and C5a Receptors on Bronchial Epithelial and Smooth Muscle Cells in Models of Sepsis and Asthma

2001 • 205 citations

The Receptor for Complement Anaphylatoxin C3a Is Expressed by Myeloid Cells and Nonmyeloid Cells in Inflamed Human Central Nervous System: Analysis in Multiple Sclerosis and Bacterial Meningitis

1998 • 203 citations

Human T Cells Express the C5a Receptor and Are Chemoattracted to C5a

1999 • 203 citations

Requirement and role of C5a in acute lung inflammatory injury in rats.

1996 • 196 citations

Impaired Inflammatory Responses in the Reverse Arthus Reaction Through Genetic Deletion of the C5a Receptor

1997 • 191 citations

Generation of C3a anaphylatoxin from human C3 by human mast cell tryptase.

1983 • 190 citations

Cutting Edge: Targeted Disruption of the C3a Receptor Gene Demonstrates a Novel Protective Anti-Inflammatory Role for C3a in Endotoxin-Shock

2000 • 187 citations

Endotoxin shock in antibody-deficient mice: unraveling the role of natural antibody and complement in the clearance of lipopolysaccharide.

1997 • 176 citations

Complement Factors C3a and C5a Are Increased in Bronchoalveolar Lavage Fluid after Segmental Allergen Provocation in Subjects with Asthma

2001 • 176 citations

Goodpasture's syndrome

1996 • 169 citations

Selective Suppression of IL-12 Production by Chemoattractants

2000 • 169 citations

C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils

1994 • 168 citations

Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? A review and a theoretical framework

2000 • 164 citations

The Human C3a Receptor Is Expressed on Neutrophils and Monocytes, but Not on B or T Lymphocytes

1997 • 164 citations

Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis

2000 • 159 citations

A Comparison of C3a and C5a-Mediated Stable Adhesion of Rolling Eosinophils in Postcapillary Venules and Transendothelial Migration In Vitro and In Vivo

1999 • 158 citations

C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins

1994 • 154 citations

Activation of human neutrophils by C3a and C5A Comparison of the effects on shape changes, chemotaxis, secretion, and respiratory burst

1994 • 150 citations

Selection of a C5a Receptor Antagonist from Phage Libraries Attenuating the Inflammatory Response in Immune Complex Disease and Ischemia/Reperfusion Injury

1999 • 144 citations

Characterization of Complement Anaphylatoxins and Their Biological Responses

1998 • 143 citations

Protective effects of anti‐C5a peptide antibodies in experimental sepsis

2001 • 135 citations

Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation.

1981 • 129 citations

Regulation of B cell functions by C3a and C3a(desArg): suppression of TNF-alpha, IL-6, and the polyclonal immune response.

1997 • 126 citations

A Codominant Role of FcγRI/III and C5aR in the Reverse Arthus Reaction

2000 • 121 citations

Regulation of IL-6 Synthesis in Human Peripheral Blood Mononuclear Cells by C3a and C3adesArg

1999 • 118 citations

Early Local Generation of C5a Initiates the Elicitation of Contact Sensitivity by Leading to Early T Cell Recruitment

2000 • 116 citations

Activated Human T Lymphocytes Express a Functional C3a Receptor

2000 • 115 citations

Cutting Edge: Guinea Pigs with a Natural C3a-Receptor Defect Exhibit Decreased Bronchoconstriction in Allergic Airway Disease: Evidence for an Involvement of the C3a Anaphylatoxin in the Pathogenesis of Asthma

2000 • 111 citations

A New Small Molecule C5a Receptor Antagonist Inhibits the Reverse-Passive Arthus Reaction and Endotoxic Shock in Rats

2000 • 107 citations

Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement.

1997 • 105 citations

Cross-desensitization of Chemoattractant Receptors Occurs at Multiple Levels

1995 • 103 citations

Augmentation of reverse arthus reaction by mast cells in mice.

1991 • 97 citations

C5a suppresses the production of IL-12 by IFN-gamma-primed and lipopolysaccharide-challenged human monocytes.

1999 • 96 citations

Distinct Tissue Site-Specific Requirements of Mast Cells and Complement Components C3/C5a Receptor in IgG Immune Complex-Induced Injury of Skin and Lung

2001 • 91 citations

Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome

1996 • 87 citations

C3a and C5a enhance granulocyte adhesion to endothelial and epithelial cell monolayers: epithelial and endothelial priming is required for C3a-induced eosinophil adhesion

2000 • 87 citations

Required Early Complement Activation in Contact Sensitivity with Generation of Local C5-dependent Chemotactic Activity, and Late T Cell Interferon γ: A Possible Initiating Role of B Cells

1997 • 84 citations

Chemotaxis by mouse macrophage cell lines.

1981 • 79 citations

rC5a Directs the In Vitro Migration of Human Memory and Naive Tonsillar B Lymphocytes: Implications for B Cell Trafficking in Secondary Lymphoid Tissues

1999 • 79 citations

Expression of high‐ and low‐affinity receptors for C3a on the human mast cell line, HMC‐1

1996 • 77 citations

C5a Suppresses the Production of IL-12 by IFN-γ-Primed and Lipopolysaccharide-Challenged Human Monocytes

1999 • 77 citations

Resistance to Antigen-Induced Airway Hyperresponsiveness Requires Endogenous Production of IL-12

1998 • 74 citations

Demonstration of a specific C3a receptor on guinea pig platelets.

1988 • 73 citations

Cutting Edge: Fc Receptor Type I for IgG on Macrophages and Complement Mediate the Inflammatory Response in Immune Complex Peritonitis

1999 • 71 citations

Chronic myelogenous leukemia‐derived basophilic granulocytes express a functional active receptor for the anaphylatoxin C3a

1993 • 69 citations

Histamine-Induced Inhibition of Normal Human Basophil Chemotaxis to C5a

1977 • 66 citations

The third component of complement protects against Escherichia coli endotoxin-induced shock and multiple organ failure.

1994 • 61 citations

Immunologic assessment of host defense impairment in patients with septic multiple organ failure: relationship between complement activation and changes in neutrophil function.

1994 • 56 citations

Neutrophil elicitation in the reverse passive Arthus reaction. Complement-dependent and -independent mast cell involvement.

1994 • 49 citations

Possible involvement of C5/C5a in the efferent and elicitation phases of contact sensitivity.

1996 • 45 citations

Different modes of pathogenesis in T‐cell‐dependent autoimmunity: clues from two TCR transgenic systems

1999 • 43 citations

Characterization of C3a anaphylatoxin receptor on guinea-pig macrophages.

1993 • 42 citations

Site-Directed C3a Receptor Antibodies from Phage Display Libraries

1998 • 34 citations

Host Defense Against Bacterial Endotoxemia-Contribution of The Early and Late Components of Complement to Detoxification

1972 • 30 citations

Effects of interleukin (IL)‐3 and IL‐5 on human eosinophil degranulation induced by complement components C3a and C5a*

1996 • 29 citations

Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor.

1998 • 29 citations

Characterization of Synthetic C3a Analog Peptides on Human Eosinophils in Comparison to the Native Complement Component C3a

2000 • 24 citations

Cutting Edge: Human Anaphylatoxin C4a Is a Potent Agonist of the Guinea Pig But Not the Human C3a Receptor

1998 • 21 citations

A covalent dimer of complement C4b serves as a subunit of a novel C5 convertase that involves no C3 derivatives.

1991 • 21 citations

A New Paradigm of T Cell Allergy: Requirement for the B–1 Cell Subset

1999 • 20 citations

Processing and Clearance of Immune Complexes by Complement and the Role of Complement in Immune Complex Diseases

1998 • 15 citations

How Similar Are in vitro Differentiated, Cord Blood Derived Eosinophils to Peripheral Blood Eosinophils?

1990 • 11 citations