Characterization of Synthetic C3a Analog Peptides on Human Eosinophils in Comparison to the Native Complement Component C3a

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

The Human Complement System in Health and Disease

1998 • 474 citations

C3a and C5a Stimulate Chemotaxis of Human Mast Cells

1997 • 326 citations

A Ca2+-insensitive form of fura-2 associated with polymorphonuclear leukocytes. Assessment and accurate Ca2+ measurement.

1987 • 317 citations

C3a is a chemotaxin for human eosinophils but not for neutrophils. I. C3a stimulation of neutrophils is secondary to eosinophil activation.

1995 • 272 citations

Molecular Cloning and Characterization of the Human Anaphylatoxin C3a Receptor

1996 • 264 citations

C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway.

1996 • 250 citations

The Cells of the Allergic Response

1997 • 182 citations

Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U‐937 cells

1996 • 180 citations

The role of eosinophils in the pathogenesis of atopic dermatitis ‐ eosinophil granule proteins as markers of disease activity

1993 • 179 citations

Human eotaxin represents a potent activator of the respiratory burst of human eosinophils

1996 • 171 citations

Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 alpha, or human interleukin 8.

1993 • 171 citations

C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils

1994 • 168 citations

The Human C3a Receptor Is Expressed on Neutrophils and Monocytes, but Not on B or T Lymphocytes

1997 • 164 citations

Interleukin 3 and granulocyte/macrophage-colony-stimulating factor render human basophils responsive to low concentrations of complement component C3a.

1990 • 160 citations

C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins

1994 • 154 citations

Structure and Function of C3a Anaphylatoxin*

1990 • 151 citations

Characterization of Complement Anaphylatoxins and Their Biological Responses

1998 • 143 citations

The Chemokine RANTES Is More than a Chemoattractant: Characterization of Its Effect on Human Eosinophil Oxidative Metabolism and Morphology in Comparison with IL-5 and GM-CSF

1994 • 106 citations

Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation.

1995 • 98 citations

5-Oxo-eicosanoids Are Potent Eosinophil Chemotactic Factors.

1995 • 91 citations

cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure

1996 • 90 citations

Surface and mRNA expression of the CD52 antigen by human eosinophils but not by neutrophils

1996 • 86 citations

Degranulation from Human Eosinophils Stimulated with C3a and C5a

1994 • 83 citations

The active site of C3a anaphylatoxin.

1980 • 82 citations

Identification of 5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid as a novel and potent human eosinophil chemotactic eicosanoid.

1992 • 81 citations

A topic dermatitis the skin manifestation of a topic

1995 • 81 citations

Synthetic peptides with the biological activities and specificity of human C3a anaphylatoxin.

1977 • 80 citations

C3a receptor on dibutyryl-cAMP-differentiated U937 cells and human neutrophils: The human C3a receptor characterized by functional responses and 125I-C3a binding

1992 • 78 citations

Designing synthetic superagonists of C3a anaphylatoxin

1991 • 77 citations

Expression of high‐ and low‐affinity receptors for C3a on the human mast cell line, HMC‐1

1996 • 77 citations

Chronic myelogenous leukemia‐derived basophilic granulocytes express a functional active receptor for the anaphylatoxin C3a

1993 • 69 citations

Mechanisms of human eosinophil activation by complement protein C5a and platelet‐activating factor: similar functional responses are accompanied by different morphologic alterations

1995 • 60 citations

Characterization of C3a receptor‐proteins on guinea pig platelets and human polymorphonuclear leukocytes

1989 • 56 citations

Actin polymerization in human eosinophils, unlike human neutrophils, depends on intracellular calcium mobilization

1996 • 47 citations

Detection of MCP-4 in dermal fibroblasts and its activation of the respiratory burst in human eosinophils.

1998 • 45 citations

Actin polymerization in human eosinophils, unlike human neutrophils, depends on intracellular calcium mobilization

1996 • 40 citations

Peptide Analogues of the Anaphylatoxin C3a; Syntheses and Properties

1989 • 38 citations

Modulation of C3a Activity: Internalization of the Human C3a Receptor and its Inhibition by C5a

1999 • 36 citations

Cutting Edge: Detection of MCP-4 in Dermal Fibroblasts and Its Activation of the Respiratory Burst in Human Eosinophils

1998 • 34 citations

Site-Directed C3a Receptor Antibodies from Phage Display Libraries

1998 • 34 citations

Design and biological activity of a new generation of synthetic C3a analogues by combination of peptidic and non-peptidic elements.

1988 • 26 citations

Reevaluation of the C3a active site using short synthetic C3a analogues

1990 • 23 citations

Synthetic peptides as antagonists of the anaphylatoxin C3a

1992 • 23 citations

Modulation of Phenotypic and Functional Properties of Normal Human Mononuclear Phagocytes by Granulocyte-Macrophage Colony-Stimulating Factor

1994 • 22 citations

Anaphylatoxins

1993 • 21 citations

Functional activities of synthetic anaphylatoxic peptides in widely used biological assays

1992 • 11 citations

Enhanced biopotency of synthetic C3a analogues by membrane binding. A fluorescence anisotropy decay study

1992 • 6 citations