Differential Effects of CC Chemokines on CC Chemokine Receptor 5 (CCR5) Phosphorylation and Identification of Phosphorylation Sites on the CCR5 Carboxyl Terminus

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION

1998 • 1,074 citations

A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.

1987 • 767 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Substitution of three amino acids switches receptor specificity of Gqα to that of Giα

1993 • 702 citations

Molecular Cloning and Functional Expression of a New Human CC-Chemokine Receptor Gene

1996 • 701 citations

Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist

1997 • 622 citations

Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1β, and MIP-1α

1996 • 454 citations

Extension of Recombinant Human RANTES by the Retention of the Initiating Methionine Produces a Potent Antagonist

1996 • 424 citations

Aminooxypentane-RANTES Induces CCR5 Internalization but Inhibits Recycling: A Novel Inhibitory Mechanism of HIV Infectivity

1998 • 409 citations

Structure-activity relationships of chemokines

1995 • 367 citations

Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor

1995 • 317 citations

Use of fluo-3 to measure cytosolic Ca2+ in platelets and neutrophils. Loading cells with the dye, calibration of traces, measurements in the presence of plasma, and buffering of cytosolic Ca2+

1990 • 303 citations

Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide.

1992 • 260 citations

Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor

1997 • 252 citations

Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C

1996 • 246 citations

Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase

1991 • 220 citations

Sequential phosphorylation of rhodopsin at multiple sites

1993 • 204 citations

Differential Regulation of G-protein-mediated Signaling by Chemokine Receptors

1996 • 195 citations

Selective G Protein Coupling by C-C Chemokine Receptors

1996 • 191 citations

Phosphorylation and Desensitization of Human Endothelin A and B Receptors

1997 • 185 citations

Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase.

1991 • 175 citations

Phosphorylation and Activation of β-Adrenergic Receptor Kinase by Protein Kinase C

1995 • 160 citations

Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2

1998 • 160 citations

Distinct but Overlapping Epitopes for the Interaction of a CC-Chemokine with CCR1, CCR3, and CCR5

1997 • 140 citations

Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors

1996 • 139 citations

Definition, function and pathophysiological significance of chemokine receptors

1998 • 123 citations

Quantification of signalling components and amplification in the β-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes

1995 • 123 citations

Characterization of the Phosphorylation Sites Involved in G Protein-coupled Receptor Kinase- and Protein Kinase C-mediated Desensitization of the α1B-Adrenergic Receptor

1997 • 123 citations

Four Consecutive Serines in the Third Intracellular Loop Are the Sites for β-Adrenergic Receptor Kinase-mediated Phosphorylation and Desensitization of the α2A-Adrenergic Receptor

1995 • 122 citations

Phosphorylation of the N-Formyl Peptide Receptor Carboxyl Terminus by the G Protein-coupled Receptor Kinase, GRK2

1995 • 108 citations

beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation.

1988 • 106 citations

Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.

1996 • 95 citations

Regulation of Human Interleukin-8 Receptor A: Identification of a Phosphorylation Site Involved in Modulating Receptor Functions

1995 • 92 citations

Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. Identification of a potential ligand binding site on the NH2-terminal domain.

1993 • 89 citations

Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function.

1996 • 88 citations

Receptor-mediated Endocytosis of CC-chemokines

1997 • 80 citations

Identification of the Major Phosphorylation Sites in Human C5a Anaphylatoxin Receptor in Vivo

1995 • 68 citations

Melanoma growth stimulatory activity enhances the phosphorylation of the class II interleukin-8 receptor in non-hematopoietic cells.

1994 • 64 citations

Differential coupling of CC chemokine receptors to multiple heterotrimeric G proteins in human interleukin-2-activated natural killer cells

1996 • 59 citations