Trafficking of glycosphingolipids in eukaryotic cells; sorting and recycling of lipids

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

Cholesterol and the cell membrane

1985 • 1,465 citations

Lipid sorting in epithelial cells

1988 • 1,354 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex

1986 • 1,175 citations

GLYCOBIOLOGY

1988 • 1,107 citations

BIOSYNTHETIC PROTEIN TRANSPORT AND SORTING BY THE ENDOPLASMIC RETICULUM AND GOLGI

1987 • 985 citations

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

1990 • 889 citations

Control of Protein Exit from the Endoplasmic Reticulum

1989 • 794 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

1986 • 702 citations

Reconstitution of the transport of protein between successive compartments of the golgi measured by the coupled incorporation of N-acetylglucosamine

1984 • 689 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Polarized sorting in epithelia

1990 • 544 citations

Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate.

1990 • 533 citations

Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation.

1984 • 501 citations

Fluorescence assay for phospholipid membrane asymmetry

1991 • 484 citations

A glycophospholipid membrane anchor acts as an apical targeting signal in polarized epithelial cells.

1989 • 478 citations

A novel fluorescent ceramide analogue for studying membrane traffic in animal cells: accumulation at the Golgi apparatus results in altered spectral properties of the sphingolipid precursor.

1991 • 478 citations

Lipid Traffic in Animal Cells

1989 • 468 citations

The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway.

1990 • 444 citations

Sorting of sphingolipids in epithelial (Madin-Darby canine kidney) cells.

1987 • 443 citations

Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus.

1983 • 430 citations

Molecular arrangements in sphingolipids Conformation and hydrogen bonding of ceramide and their implication on membrane stability and permeability

1976 • 419 citations

Organization of Glycosphingolipids in Bilayers and Plasma Membranes of Mammalian Cells

1985 • 395 citations

The Structure of Biological Membranes

1976 • 393 citations

Mechanism of Membrane Anchoring Affects Polarized Expression of Two Proteins in MDCK Cells

1989 • 377 citations

Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus.

1990 • 369 citations

Multiple targets for brefeldin A

1991 • 347 citations

Saposin proteins: structure, function, and role in human lysosomal storage disorders

1991 • 328 citations

Transbilayer movement of phospholipids in red cell and platelet membranes

1991 • 317 citations

Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions

1992 • 306 citations

Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane.

1990 • 304 citations

Glycolipids at the cell surface and their biological functions

1978 • 299 citations

Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts: endogenously synthesized sphingomyelin and glucocerebroside analogues pass through the Golgi apparatus en route to the plasma membrane.

1985 • 297 citations

Defining Lipid Transport Pathways in Animal Cells

1985 • 294 citations

Biochemistry of Lipids and Membranes

1986 • 286 citations

Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver

1991 • 282 citations

Nanometre-level analysis demonstrates that lipid flow does not drive membrane glycoprotein movements

1989 • 281 citations

Photoconversion of some fluorescent markers to a diaminobenzidine product.

1988 • 272 citations

CYTOCHEMISTRY OF GOLGI FRACTIONS PREPARED FROM RAT LIVER

1974 • 263 citations

Molecular trapping of a fluorescent ceramide analogue at the Golgi apparatus of fixed cells: interaction with endogenous lipids provides a trans-Golgi marker for both light and electron microscopy.

1989 • 258 citations

Cell regulation by sphingosine and more complex sphingolipids

1991 • 242 citations

Intracellular transport and metabolism of sphingomyelin

1991 • 236 citations

Glycophospholipid membrane anchoring provides clues to the mechanism of protein sorting in polarized epithelial cells

1990 • 233 citations

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

1990 • 230 citations

The physical properties of glycolipids

1987 • 225 citations

Lipid recycling between the plasma membrane and intracellular compartments: transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts.

1989 • 221 citations

Sphingomyelin is synthesized in the cis Golgi

1990 • 187 citations

Protein sorting by selective retention in the endoplasmic reticulum and Golgi stack

1987 • 179 citations

Metabolism and intracellular transport of glycosphingolipids

1990 • 178 citations

Glycolipid function

1987 • 175 citations

A human membrane-associated folate binding protein is anchored by a glycosyl-phosphatidylinositol tail

1989 • 173 citations

Selectivity of fluorescent lipid analogs for lipid domains

1980 • 166 citations

Ricin transport in brefeldin A-treated cells: correlation between Golgi structure and toxic effect.

1991 • 152 citations

Membrane traffic and organelle division

1985 • 152 citations

Lateral diffusion of membrane-spanning and glycosylphosphatidylinositol-linked proteins: toward establishing rules governing the lateral mobility of membrane proteins.

1991 • 146 citations

Topology of glucosylceramide synthesis in Golgi membranes from porcine submaxillary glands

1986 • 143 citations

Temperature and energy dependence of secretory protein transport in the exocrine pancreas.

1986 • 140 citations

The pathways of endocytosed transferrin and secretory protein are connected in the trans-Golgi reticulum.

1988 • 132 citations

Perforated MDCK cells support intracellular transport.

1987 • 129 citations

Uncoupling of ganglioside biosynthesis by Brefeldin A.

1990 • 124 citations

Sorting of an internalized plasma membrane lipid between recycling and degradative pathways in normal and Niemann-Pick, type A fibroblasts.

1990 • 123 citations

Neurobiology of Glycoconjugates

1990 • 123 citations

Lipid Transport During Mitosis

1989 • 119 citations

Lateral diffusion and retrograde movements of individual cell surface components on single motile cells observed with Nanovid microscopy.

1991 • 117 citations

Mixed-chain phosphatidylcholine bilayers: structure and properties

1987 • 112 citations

Modulation of Ganglioside Biosynthesis in Primary Cultured Neurons

1989 • 111 citations

An α-N-Acetylgalactosaminylation at the Threonine Residue of a Defined Peptide Sequence Creates the Oncofetal Peptide Epitope in Human Fibronectin

1989 • 99 citations

Topography of glycosyltransferases involved in the initial glycosylations of gangliosides.

1991 • 98 citations

Glycosphingolipids as differentiation-dependent, tumor-associated markers and as regulators of cell proliferation

1984 • 98 citations

Modulation of renal epithelial cell growth by glucosylceramide. Association with protein kinase C, sphingosine, and diacylglycerol.

1991 • 98 citations

Ganglioside GM3:GD3 ratio as an index for the management of melanoma

1991 • 94 citations

Gangliosides and Modulation of Neuronal Functions

1987 • 87 citations

A photoreactive derivative of radiolabeled GM1 ganglioside: preparation and use to establish the involvement of specific proteins in GM1 uptake by human fibroblasts in culture

1989 • 87 citations

Endocytosis and intracellular transport of the glycolipid-binding ligand Shiga toxin in polarized MDCK cells.

1991 • 87 citations

Sorting of sphingolipids in the endocytic pathway of HT29 cells.

1991 • 86 citations

Shedding of human neuroblastoma gangliosides

1991 • 85 citations

Sialidase activities of cultured human fibroblasts and the metabolism of GM3 ganglioside.

1988 • 83 citations

Chapter 5 A Fluorescent Derivative of Ceramide: Physical Properties and Use in Studying the Golgi Apparatus of Animal Cells

1988 • 83 citations

Membrane fusion of enveloped viruses: Especially a matter of proteins

1990 • 82 citations

Antibody response to immunization with ganglioside GD3 and GD3 congeners (lactones, amide and gangliosidol) in patients with malignant melanoma

1991 • 76 citations

Isolation of a functional vesicular intermediate that mediates ER to Golgi transport in yeast.

1990 • 76 citations

Antitumor activity via inhibition of glycosphingolipid biosynthesis

1987 • 74 citations

Two Glycosphingolipid Sialyltransferases Are Localized in Different Sub-Golgi Compartments in Rat Liver

1989 • 73 citations

A non-exchangeable fluorescent phospholipid analog as a membrane traffic marker of the endocytic pathway.

1990 • 72 citations

Incorporation of fluorescent gangliosides into human fibroblasts: mobility, fate, and interaction with fibronectin.

1984 • 72 citations

Association of gangliosides to fibroblasts in culture: A study performed with GM1 [14C]-labelled at the sialic acid acetyl group

1985 • 69 citations

Intracellular localization of lactosylceramide, the major human neutrophil glycosphingolipid.

1987 • 67 citations

Glycolipid and glycoprotein transport through the Golgi complex are similar biochemically and kinetically. Reconstitution of glycolipid transport in a cell free system.

1990 • 65 citations

Incorporation and metabolism of exogenous GM1 ganglioside in rat liver

1986 • 65 citations

Glucocerebroside transfer between phosphatidylcholine bilayers

1982 • 63 citations

Patterns of endogenous gangliosides and metabolic processing of exogenous gangliosides in cerebellar granule cells during differentiation in culture

1990 • 62 citations

Cell‐free systems to study vesicular transport along the secretory and endocytic pathways ¹

1989 • 60 citations

Reconstitution of steps in the constitutive secretory pathway in permeabilized cells. Secretion of glycosylated tripeptide and truncated sphingomyelin.

1990 • 60 citations

Glycolipid transfer protein and intracellular traffic of glucosylceramide

1990 • 58 citations

Action of monensin, a monovalent cationophore, on cultured human fibroblasts: evidence that it induces high cellular accumulation of glucosyl- and lactosylceramide (gluco- and lactocerebroside)

1984 • 58 citations

Sub-Golgi distribution in rat liver of CMP-NeuAc GM3- and CMP-NeuAc:GT1b alpha 2—-8sialyltransferases and comparison with the distribution of the other glycosyltransferase activities involved in ganglioside biosynthesis.

1990 • 55 citations

Substrate specificity of α2↔3‐sialyltransferases in ganglioside biosynthesis of rat liver golgi^*

1991 • 54 citations

Recycling glycoproteins do not return to the cis-Golgi.

1988 • 54 citations

Gangliosides: the relevance of current research to neurosurgery

1991 • 54 citations

Glycosphingolipids of human gliomas.

1990 • 54 citations

Effect of drugs and temperature on biosynthesis and transport of glycosphingolipids in cultured neurotumor cells

1984 • 53 citations

Lipid Exchange: Transmembrane Movement, Spontaneous Movement, and Protein-Mediated Transfer of Lipids and Cholesterol

1987 • 52 citations

Organelle biogenesis and intracellular lipid transport in eukaryotes.

1991 • 51 citations

Polarity signals

1991 • 50 citations

Trafficking of lipids from the endoplasmic reticulum to the Golgi apparatus in a cell-free system from rat liver

1991 • 49 citations

Lysosomal and Plasma Membrane Ganglioside GM3 Sialidases of Cultured Human Fibroblasts. Differentiation by Detergents and Inhibitors

1991 • 46 citations

The isolation of endosome-derived vesicles from rat hepatocytes

1983 • 46 citations

Ricinus communis agglutinin-mediated agglutination and fusion of glycolipid-containing phospholipid vesicles: effect of carbohydrate head group size, calcium ions, and spermine

1986 • 45 citations

Stimulation of liver growth and DNA synthesis by glucosylceramide

1988 • 44 citations

Characterization and Changes of Glycosphingolipids in the Aorta of the Watanabe Hereditable Hyperlipidemic Rabbit1

1991 • 42 citations

Immunochemical detection of a small cell lung cancer-associated ganglioside (FucG(M1)) antigen in serum

1992 • 42 citations

Effects of sphingomyelin degradation on cholesterol mobilization and efflux to high-density lipoproteins in cultured fibroblasts

1990 • 41 citations

Epithelial sphingolipid sorting allows for extensive variation of the fatty acyl chain and the sphingosine backbone

1992 • 38 citations

Increased steroid hormone secretion in mouse Leydig tumor cells after induction of cholesterol translocation by sphingomyelin degradation

1991 • 37 citations

Cerebellar granule cells in culture exhibit a ganglioside‐sialidase presumably linked to the plasma membrane

1991 • 34 citations

[52] Use of N-([1-14C]Hexanoyl)-D-erythro-sphingolipids to assay sphingolipid metabolism

1992 • 31 citations

Organelles in eukaryotic cells : molecular structure and interactions

1989 • 30 citations

Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor

1991 • 28 citations

Overcoming random diffusion in polarized cells – corralling the drunken beggar

1987 • 26 citations

Synthesis of cerebroside, lactosyl ceramide, and ganglioside GM3 analogs containing β-thioglycosidically linked ceramide

1991 • 24 citations

Enhanced expression of ganglioside GD3 in human and rat hepatocellular carcinoma cells and NIH 3T3 cells transfected with human tumor DNAs.

1990 • 21 citations

Coated endosomal vesicles: sorting and recycling compartment for transferrin in BHK cells.

1991 • 21 citations

A part of glucosylceramide formed from exogenous lactosylceramide is not degraded to ceramide but re-cycled and glycosylated in the Golgi apparatus

1991 • 15 citations

Regulation of glycolipid synthesis during differentiation of clonal murine muscle cells

1990 • 14 citations

Activation of 5-[125I]iodonaphthyl-1-azide via excitation of fluorescent (N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)) lipid analogs in living cells. A potential tool for identification of compartment-specific proteins and proteins involved in intracellular transport and metabolism of lipids

1991 • 13 citations

Divergent fate of unsaturated and saturated ceramides and sphingomyelins in rat liver and cells in culture

1989 • 13 citations

Lectin-Carbohydrate Interactions in Model and Biological Membrane Systems

1989 • 13 citations

Metabolism of Ganglioside-Amides in Cultured Human Fibroblasts

1987 • 10 citations

SV-40 transformation: effect on GM2 ganglioside in cultured cell lines

1991 • 7 citations

Metabolism of cholesterol, phosphatidylethanolamine and stearylamine analogues of GM1 ganglioside by rat glioma C6 cells

1991 • 7 citations

Gangliosides depleted in plasma membrane are directed to internal membranes of rat hepatomas: Evidence for a glycolipid sorting defect in hepatocarcinogenesis

1990 • 5 citations

Metabolism of 3-[3H]sphingosine sphingomyelin labeled with [14C]palmitic or [14C]linoleic acid by Hep G2 cells and rat liver in vivo

1991 • 5 citations