Agonist/antagonist interactions with cloned human 5-HT1A receptors: variations in intrinsic activity studied in transfected HeLa cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

1986 • 1,255 citations

Operational models of pharmacological agonism

1983 • 1,062 citations

Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

1988 • 691 citations

The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor

1988 • 594 citations

Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin

1985 • 581 citations

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 509 citations

Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene.

1990 • 444 citations

Structure and functional expression of cloned rat serotonin 5HT-2 receptor.

1988 • 381 citations

5-Hydroxytryptamine Receptor Subtypes

1988 • 361 citations

An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation

1985 • 295 citations

Effector Coupling Mechanisms of the Cloned 5-HT1A Receptor

1989 • 273 citations

Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists.

1990 • 227 citations

Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist?

1989 • 168 citations

Centrally acting hypotensive agents with affinity for 5‐HT_1A binding sites inhibit forskolin‐stimulated adenylate cyclase activity in calf hippocampus

1988 • 151 citations

Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture.

1988 • 150 citations

Identification of serotonin 5-HT3 recognition sites in membranes of N1E-115 neuroblastoma cells by radioligand binding.

1988 • 149 citations

Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neurons

1987 • 136 citations

Mixed agonist/antagonist properties of NAN-190 at 5-HT1A Receptors: Behavioural and in vivo brain microdialysis studies

1990 • 133 citations

BMY 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-HT1A receptor in rat and guinea pig hippocampal membranes

1987 • 128 citations

How selective is GR 43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors

1989 • 116 citations

Protein kinase C induces phosphorylation and desensitization of the human 5-HT1A receptor

1991 • 115 citations

Characterization of MDL 73005EF as a 5‐HT_1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepam

1990 • 113 citations

Theoretical effects of single and multiple transducer receptor coupling proteins on estimates of the relative potency of agonists.

1989 • 113 citations

Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378

1990 • 109 citations

Neurochemistry and Neurophysiology of Buspirone and Gepirone

1990 • 85 citations

NAN-190: agonist and antagonist interactions with brain 5-HT1A receptors

1990 • 80 citations

Dual couplings of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein

1991 • 72 citations

5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools.

1991 • 69 citations

The Human 5-HT1A Receptor Expressed in HeLa Cells Stimulates Sodium-dependent Phosphate Uptake via Protein Kinase C

1989 • 54 citations

The behavioural, but not the hypothermic or corticosterone, response to 8-hydroxy-2-(di-n-propylamino)-tetralin, is antagonized by nan-190 in the rat

1990 • 53 citations

Effects of MDL 73005EF on central pre- and postsynaptic 5-HT1A receptor function in the rat in vivo

1990 • 51 citations

[10] Use of intracellular calcium and membrane potential fluorescent indicators in neuroendocrine cells

1986 • 41 citations

Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells.

1990 • 33 citations

[3H]Spiroxatrine labels a serotonin1A-like site in the rat hippocampus

1987 • 32 citations

[³H]Spiroxatrine: A 5‐HT_1A Radioligand with Agonist Binding Properties

1988 • 30 citations

MDL 73005EF: partial agonist at the 5-HT1A receptor negatively linked to adenylate cyclase

1989 • 24 citations

Cloning and Expression of a Human 5-HT1D Receptor

1991 • 20 citations

MDL 72832 and MDL 73005EF: Novel, potent and selective 5-HT1A receptor ligands with different pharmacological properties

1990 • 18 citations

Use of Intracellular Calcium and Membrane Potential Fluorescent Indicators in Neuroendocrine Cells

1989 • 9 citations

BMY 7378: Partial agonist at spinal cord 5-HT1A receptors

1990 • 8 citations