Diacylglycerol generation and phosphoinositide turnover in human neutrophils: Effects of particulate versus soluble stimuli

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Oxidants from phagocytes: agents of defense and destruction

1984 • 803 citations

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

1975 • 749 citations

The extinction coefficient of cytochrome c

1962 • 693 citations

The O2−-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function

1986 • 665 citations

The polyphosphoinositide phosphodiesterase of erythrocyte membranes

1981 • 614 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes

1976 • 357 citations

Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N Protein

1986 • 324 citations

Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.

1986 • 294 citations

Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux.

1984 • 272 citations

The Biochemical Basis of Phagocytosis

1960 • 267 citations

Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action

1983 • 203 citations

Receptor-Mediated Internalization of Fluorescent Chemotactic Peptide by Human Neutrophils

1979 • 188 citations

Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation.

1985 • 182 citations

Model for Leukocyte Regulation by Chemoattractant Receptors: Roles of a Guanine Nucleotide Regulatory Protein and Polyphosphoinositide Metabolism

1986 • 181 citations

Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes

1988 • 163 citations

The Metabolic Basis of Phagocytosis

1961 • 159 citations

Unsaturated fatty acids as second messengers of superoxide generation by macrophages

1983 • 157 citations

Receptor-mediated activation of electropermeabilized neutrophils. Evidence for a Ca2+- and protein kinase C-independent signaling pathway.

1988 • 153 citations

Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187

1984 • 152 citations

Identification of distinct activation pathways of the human neutrophil NADPH-oxidase.

1986 • 148 citations

Receptor-cytoskeleton interactions and membrane traffic may regulate chemoattractant-induced superoxide production in human granulocytes.

1986 • 144 citations

Multiple forms of myeloperoxidase from human neutrophilic granulocytes: Evidence for differences in compartmentalization, enzymatic activity, and subunit structure

1983 • 134 citations

Cytochalasin B enhancement of the diacylglycerol response in formyl peptide-stimulated neutrophils.

1986 • 133 citations

Interaction between human neutrophils and zymosan particles: the role of opsonins and divalent cations.

1981 • 128 citations

Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst.

1988 • 119 citations

Effect of anti-inflammatory drugs and agents that elevate intracellular cyclic AMP on the release of toxic oxygen metabolites by phagocytes: Studies in a model of tissue-bound IgG

1978 • 114 citations

Diacylglycerol accumulation and superoxide anion production in stimulated human neutrophils.

1987 • 103 citations

Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.

1988 • 101 citations

Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.

1986 • 85 citations

Release of superoxide and change in morphology by neutrophils in response to phorbol esters: antagonism by inhibitors of calcium-binding proteins.

1985 • 83 citations

The fate of an N-formylated chemotactic peptide in stimulated human granulocytes. Subcellular fractionation studies.

1983 • 82 citations

Subcellular localization of H2O2 production in human neutrophils stimulated with particles and an effect of cytochalasin-B on the cells

1982 • 80 citations

Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils.

1988 • 79 citations

Activation of nadph-oxidase by arachidonic acid involves phospholipase A2 in intact human neutrophils but not in the cell-free system

1986 • 70 citations

Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): Role of extracellular Ca2+

1984 • 63 citations

Neutrophil degranulation: Evidence pertaining to its mediation by the combined effects of leukotriene B₄, platelet‐activating factor, and 5‐HETE

1985 • 62 citations

Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release.

1988 • 57 citations

Chemoattractant-mediated stimulation of the respiratory burst in human polymorphonuclear leukocytes may require appearance of protein kinase activity in the cells' particulate fraction

1986 • 55 citations

Influence of type and opsonization of ingested particle on intracellular free calcium distribution and superoxide production by human neutrophils

1987 • 54 citations

Platelet-activating factor as a stimulus of exocytosis in human neutrophils

1986 • 51 citations

Features of the translocation of protein kinase C in neutrophils stimulated with the chemotactic peptide f-Met-Leu-Phe

1986 • 46 citations

Differential mechanisms of translocation of protein kinase C to plasma membranes in activated human neutrophils

1986 • 46 citations

Stimulus-specific induction of phospholipid and arachidonic acid metabolism in human neutrophils

1987 • 42 citations

Effects of a protein kinase C inhibitor, K-252a, on human polymorphonuclear neutrophil responsiveness

1988 • 27 citations

Stimulation of the incorporation of 32Pi and myo-[2-3H]inositol into the phosphoinositides in polymorphonuclear leukocytes during phagocytosis

1974 • 26 citations

Immunocytochemical localization of protein kinase C in resting and activated human neutrophils

1987 • 21 citations