p53 Mutation and MDM2 amplification are rare even in human papillomavirus-negative cervical carcinomas

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.

1983 • 2,011 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

p53 function and dysfunction

1992 • 1,918 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Gain of function mutations in p53

1993 • 876 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

1992 • 587 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

1993 • 535 citations

p53: At the Crossroads of Molecular Carcinogenesis and Risk Sssessment

1993 • 477 citations

Molecular Pathogenesis of Cancer of the Cervix and Its Causation by Specific Human Papillomavirus Types

1994 • 381 citations

MDM2 gene amplification in metastatic osteosarcoma.

1993 • 340 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours

1992 • 313 citations

Introduction of human chromosome 11 via microcell transfer controls tumorigenic expression of HeLa cells.

1986 • 301 citations

The polymerase chain reaction: a new epidemiological tool for investigating cervical human papillomavirus infection.

1989 • 277 citations

p53 point mutation in HPV negative human cervical carcinoma cell lines.

1991 • 271 citations

It was a very good year for DNA repair

1994 • 181 citations

General primer‐mediated polymerase chain reaction permits the detection of sequenced and still unsequenced human papillomavirus genotypes in cervical scrapes and carcinomas

1990 • 180 citations

Alterations of the p53 gene in human primary cervical carcinoma with and without human papillomavirus infection.

1992 • 177 citations

p53 mutations in ovarian cancer: a late event?

1991 • 151 citations

Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.

1992 • 146 citations

Polymorphism at codon 213 within the p53 gene.

1991 • 137 citations

Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53

1993 • 128 citations

Analysis of the p53 gene in human uterine carcinoma cell lines.

1991 • 105 citations

Detection of human papillomavirus DNA in prostate gland tissue by using the polymerase chain reaction amplification assay

1990 • 97 citations

Mutations of p53 and human papillomavirus infection in cervical carcinoma

1993 • 91 citations

Status of c-myc, p53 and retinoblastoma genes in human papillomavirus positive and negative squamous cell carcinomas of the anus.

1991 • 91 citations

p53 mutations in HPV-negative cervical carcinoma.

1994 • 84 citations

p53 gene mutations and MDM2 amplification are uncommon in primary carcinomas of the uterine cervix.

1993 • 70 citations

Loss of heterozygosity on chromosome 17p and mutant p53 in HPV-negative cervical carcinomas

1992 • 54 citations

Absence of Mutation in the p53 and the Retinoblastoma Susceptibility Genes in Primary Cervical Carcinomas

1993 • 46 citations

Frequent Occurrence of p53 Gene Mutations in Uterine Cancers at Advanced Clinical Stage and with Aggressive Histological Phenotypes

1992 • 45 citations

The short arm of chromosome 11 likely is involved in the regulation of the human papillomavirus type 16 early enhancer-promoter and in the suppression of the transforming activity of the viral DNA

1990 • 40 citations

Infrequency of MDM2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas.

1993 • 38 citations

The state of p53 in primary human cervical carcinomas and its effects in human papillomavirus-immortalized human cervical cells.

1993 • 32 citations

Correlation between HPV Positivity and State of the p53 Gene in Cervical Carcinoma Cell Lines

1993 • 30 citations

Cervical carcinoma: low frequency of allele loss at loci implicated in other common malignancies

1993 • 24 citations

Clonal p53 Mutation in Primary Cervical Cancer

1993 • 5 citations