Infrequency of MDM2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas.

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

1993 • 535 citations

MDM2 gene amplification in metastatic osteosarcoma.

1993 • 340 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

Frequency and diversity of p53 mutations in childhood rhabdomyosarcoma.

1992 • 176 citations