Multiple actions of synthetic ‘progestins’ on the growth of ZR-75-1 human breast cancer cells: Anin vitro model for the simultaneous assay of androgen, progestin, estrogen, and glucocorticoid agonistic and antagonistic activities of steroids

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

The pharmacology and clinical uses of tamoxifen

1984 • 873 citations

Estrogenic Regulation of Growth and Polypeptide Growth Factor Secretion in Human Breast Carcinoma

1987 • 576 citations

Establishment and characterization of three new continuous cell lines derived from human breast carcinomas.

1978 • 373 citations

Induction and Extinction of Mammary Cancer

1962 • 331 citations

Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues

1986 • 252 citations

Adrenal Steroid Antagonism

1984 • 208 citations

Stimulation of cell proliferation and estrogenic response by adrenal C19-delta 5-steroids in the ZR-75-1 human breast cancer cell line.

1986 • 201 citations

Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line

1988 • 174 citations

Antiestrogenic Effect of R5020, a Synthetic Progestin in Human Breast Cancer Cells in Culture*

1983 • 173 citations

RU 38486: An Original Multifaceted Antihormone in Vivo

1984 • 163 citations

Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and megestrol acetate

1985 • 157 citations

Growth inhibition and increase of insulin receptors in antiestrogen-resistant T47DCO human breast cancer cells by progestins: implications for endocrine therapies.

1985 • 141 citations

Effect of medroxyprogesterone acetate on proliferation and cell cycle kinetics of human mammary carcinoma cells.

1988 • 139 citations

Steroid hormone receptors and pharmacology

1980 • 139 citations

Progestin Action and Progesterone Receptor Structure in Human Breast Cancer: A Review

1985 • 136 citations

Apparent Positive Cooperative Effects in Cyclic AMP and Corticosterone Production by Isolated Adrenal Cells in Response to ACTH Analogues

1974 • 116 citations

Androgenic, Antiandrogenic, and Synandrogenic Actions of Progestins: Role of Steric and Allosteric Interactions with Androgen Receptors*

1978 • 106 citations

An Exact Correction to the “Cheng-Prusoff” Correction

1988 • 105 citations

Down-Regulation of Estrogen Receptors by Androgens in the ZR-75-1 Human Breast Cancer Cell Line*

1989 • 103 citations

Progestin effects on growth in the human breast cancer cell line T-47D—Possible therapeutic implications

1987 • 98 citations

Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture

1988 • 90 citations

Analysis of the androgenic activity of synthetic “progestins” currently used for the treatment of prostate cancer

1987 • 90 citations

Androgen and glucocorticoid receptor-mediated inhibition of cell proliferation by medroxyprogesterone acetate in ZR-75-1 human breast cancer cells

1989 • 85 citations

Synthesis and biological activity of new halo-steroidal antiestrogens

1991 • 82 citations

A simple method to determine whole cell uptake of radiolabelled oestrogen and progesterone and their subcellular localization in breast cancer cell lines in monolayer culture

1984 • 80 citations

Control of Hormone Receptor Levels and Growth of 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors by Estrogens, Progesterone and Prolactin

1977 • 74 citations

Anti-Androgenicity of Flutamide and its Metabolite Sch 16423

1979 • 72 citations

Pharmacokinetic and pharmacodynamic basis for the treatment of metastatic breast cancer with high-dose medroxyprogesterone acetate

1984 • 71 citations

Treatment of metastatic breast cancer patients with different dosages of megestrol acetate; dose relations, metabolic and endocrine effects

1984 • 71 citations

Direct inhibition of growth and antagonism of insulin action by glucocorticoids in human breast cancer cells in culture.

1979 • 55 citations

An Antiestrogenic Action of Androgens in Human Breast Cancer Cells*

1981 • 55 citations

Binding of glucocorticoid antagonists to androgen and glucocorticoid hormone receptors in rat skeletal muscle

1986 • 54 citations

Estrogenic activity of phenol red in rat anterior pituitary cells in culture

1986 • 54 citations

Progestational agents in advanced breast cancer: an overview.

1986 • 53 citations

Megestrol acetate v tamoxifen in advanced breast cancer: correlation of hormone receptors and response.

1986 • 40 citations

Evidence that a non-aromatizable metabolite of norethisterone induces estrogen-dependent pituitary progestin receptors

1986 • 39 citations

[The metabolism of norethisterone (17 -ethinyl-4-estren-17 -ol-3-one) and of DL- and D-norgestrel (18-methyl-17 -ethinyl-4-estren-17 -ol-3-one) in man. (Alkyl-substituted steroids. 8)].

1971 • 38 citations

The metabolism of 19-nor contraceptive progestins modulates their biological activity at the neuroendocrine level

1987 • 35 citations

Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats

1973 • 34 citations

Progestin inhibition of estrogen-dependent proliferation in ZR-75-1 human breast cancer cells: Antagonism by insulin

1989 • 32 citations

High Inhibitory Activity of R 5020, A Pure Progestin, at the Hypothalamic-Adenohypophyseal Level on Gonadotropin Secretion

1977 • 32 citations

Accumulation of norethindrone and individual metabolites in human plasma during short- and long-term administration of a contraceptive dosage

1979 • 31 citations

Synthetic progestins stimulate prostatic binding protein messenger RNAs in the rat ventral prostate

1990 • 30 citations

Progesterone metabolism in T47Dco human breast cancer cells—II. Intracellular metabolic path of progesterone and synthetic progestins

1986 • 29 citations

ZUM STOFFWECHSEL VON NORETHISTERON (17α-ÄTHINYL-4-ÖSTREN-17β-OL-3-ON) UND DL- SOWIE D-NORGESTREL (18-METHYL-17α-ÄTHINYL-4-ÖSTREN-17β-OL-3-ON) BEIM MENSCHEN

1971 • 28 citations

Interaction of prolactin, estrogen and progesterone in a human mammary carcinoma cell line, cama-1—I. cell growth and thymidine uptake

1981 • 24 citations

The effectiveness of the routine clinic visit in the follow-up of breast cancer patients: Analysis of a defined patient cohort

1998 • 24 citations

Metabolic profiles of endogenous and ethynyl steroids in plasma and urine from women during administration of oral contraceptives

1987 • 22 citations

The relationship between growth and androstenedione metabolism in four cell lines of human breast carcinoma cells in culture

1985 • 18 citations

Hochdosiertes Medroxyprogesteronacetat beim metastasierenden Mammakarzinom: Beziehung zwischen Krankheitsverlauf und Hormonprofilen

1983 • 16 citations

Steroid hormones—agonists and antagonists

1981 • 12 citations

Oral High-Dose Progestins as Treatment for Advanced Breast Cancer

1989 • 12 citations

Oral Contraceptives and Breast Cancer: the Current Controversy

1985 • 8 citations

Estradiol and progesterone receptors content and response to norethisterone treatment in advanced breast cancer

1982 • 8 citations

Steroid Receptors in Megestrol Acetate Therapy

1984 • 6 citations

The characterization of sulphated metabolites of norethindrone in human milk after oral administration of contraceptive steroids

1987 • 5 citations

[High dose medroxyprogesterone acetate in metastatic breast cancer. Comparative clinical, pharmacokinetic and pharmacodynamic data of different forms of administration].

1982 • 4 citations

Metabolism of natural and synthetic steroids used in cancer treatment

1988 • 3 citations