Metabolism of natural and synthetic steroids used in cancer treatment

Studies on Prostatic Cancer. I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate

1941 • 3,235 citations

Progress in Clinical and Biological Research

1979 • 1,317 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region

1983 • 700 citations

Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation.

1979 • 567 citations

Handbook of Physiology Section 7: Endocrinology

1976 • 448 citations

Effect of obesity on conversion of plasma androstenedione to estrone in postmenopausal women with and without endometrial cancer

1978 • 438 citations

Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA.

1984 • 390 citations

RAPID INDUCTION OF MAMMARY CARCINOMA IN THE RAT AND THE INFLUENCE OF HORMONES ON THE TUMORS

1959 • 376 citations

TRANSCORTIN: A CORTICOSTEROID-BINDING PROTEIN OF PLASMA*†

1959 • 371 citations

The Effect of an Aromatase Inhibitor, 4-Hydroxy-4-Androstene- 3,17-Dione, On Estrogen-Dependent Processes in Reproduction and Breast Cancer¹¹

1977 • 369 citations

Comparative binding affinity of estrogens and its relation to estrogenic potency

1969 • 335 citations

Metabolic Conjugation and Metabolic Hydrolysis

1970 • 325 citations

Estrogen-Induced Uterine Responses and Growth: Relationship to Receptor Estrogen Binding by Uterine Nuclei1¹

1975 • 321 citations

Progesterone receptors in normal and neoplastic tissues

1977 • 310 citations

Pressor Attacks during Treatment with Monoamine-oxidase Inhibitors

1965 • 287 citations

Female sex steroids: receptors and function.

1979 • 273 citations

Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues

1986 • 252 citations

Glucocorticoid-induced inhibition of T cell growth factor production. II. The effect on the in vitro generation of cytolytic T cells.

1979 • 244 citations

PREDNISONE SIDE-EFFECTS AND SERUM-PROTEIN LEVELS

1971 • 240 citations

4-HYDROXYANDROSTENEDIONE IN TREATMENT OF POSTMENOPAUSAL PATIENTS WITH ADVANCED BREAST CANCER

1984 • 235 citations

Biological Activities of Steroids in Relation to Cancer

1961 • 232 citations

INHIBITION OF MAMMALIAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE BY STEROIDS

1960 • 224 citations

RELATION BETWEEN URINARY ANDROGEN AND CORTICOID EXCRETION AND SUBSEQUENT BREAST CANCER

1971 • 224 citations

Inhibition of spontaneous breast cancer formation in female C3H(Avy/a) mice by long-term treatment with dehydroepiandrosterone.

1979 • 223 citations

Methyltrienolone, a specific ligand for cellular androgen receptors

1975 • 213 citations

Progress in Cancer Research and Therapy.

1978 • 195 citations

The Prostatic Cell: Structure and Function

1982 • 178 citations

The relationship between nuclear receptor·estrogen binding and uterotrophic responses

1972 • 176 citations

SELECTION OF BREAST-CANCER PATIENTS FOR ADRENALECTOMY OR HYPOPHYSECTOMY BY DETERMINATION OF URINARY 17-HYDROXYCORTICOSTEROIDS AND ÆTIOCHOLANOLONE

1960 • 165 citations

Purification and distribution of a major protein in rat prostate that binds estramustine, a nitrogen mustard derivative of estradiol-17 beta.

1979 • 148 citations

Regulation of IL 3 expression by glucocorticoids in cloned murine T lymphocytes.

1985 • 147 citations

The inhibition of croton oil-promoted mouse skin tumorigenesis by steroid hormones.

1972 • 145 citations

Nuclear Receptor—Estrogen Complex: Relationship Between Concentration and Early Uterotrophic Responses1

1973 • 143 citations

Prostatein. A major secretory protein of the rat ventral prostate.

1979 • 140 citations

Characterization of the Dunning R3327H prostatic adenocarcinoma: an appropriate animal model for prostatic cancer.

1977 • 135 citations

Purification and Characterisation of Prostatic Binding Protein and Its Subunits

1978 • 123 citations

Serum androgens and estrogens in postmenopausal women with and without endometrial cancer

1980 • 117 citations

Glucocorticoid-Induced Inhibition of T Cell Growth Factor Production

1979 • 110 citations

Androgen Production and Conversion to Estrogens in Normal Postmenopausal Women and in Selected Breast Cancer Patients

1973 • 109 citations

4-Azasteroidal 5 alpha-reductase inhibitors without affinity for the androgen receptor.

1984 • 104 citations

Inhibition of Peripheral Aromatization by Aromatase Inhibitors, 4-Hydroxy- and 4-Acetoxy-Androstene-3,17 Dione*

1980 • 99 citations

Aromatase inhibitors. Synthesis and biological activity of androstenedione derivatives

1985 • 96 citations

Binding of [3H] methyltrienolone (R 1881) in rat prostate and human benign prostatic hypertrophy (BPH)

1976 • 94 citations

Stimulation of Arylsulfotransferase Activity by Progestins in Human Endometrium in Vitro*

1981 • 90 citations

Growth and Cell Survival Following Treatment with Estramustine, Nor-Nitrogen Mustard, Estradiol and Testosterone of a Human Prostatic Cancer Cell Line (DU 145)

1982 • 89 citations

6α-Methyl-17α-HYDROXYPROGESTERONE 17-ACYLATES; A NEW CLASS OF POTENT PROGESTINS¹

1958 • 87 citations

HOST ENVIRONMENT INTERACTIONS IN THE ETIOLOGY OF CANCER IN MAN

1973 • 85 citations

Identification and biological activity of tamoxifen metabolites in human serum

1983 • 85 citations

Cytotoxic estrogens in hormone receptive tumors

1981 • 76 citations

SOME CHEMICAL AND BIOLOGICAL PROPERTIES OF 19-NOR-17?-ETHYNYLTESTOSTERONE

1958 • 73 citations

Partial characterization and "quantitation" of a human prostatic estramustine-binding protein.

1982 • 71 citations

Aromatase inhibitors—iv. Regression of hormone-dependent, mammary tumors in the rat with 4-acetoxy-4-androstene-3,17-dione

1979 • 70 citations

Influence of androgens on the concentration of prostatic binding protein (PBP) and its mRNA in rat prostate

1977 • 67 citations

Pharmacology of an antiandrogen, anandron, used as an adjuvant therapy in the treatment of prostate cancer

1986 • 66 citations

Effects of aromatase inhibitors, aminoglutethimide, and 4-hydroxyandrostenedione on cyclic rats and rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors.

1985 • 65 citations

METABOLISM OF ETHYNYLOESTRADIOL IN MAN

1972 • 63 citations

Protective effect of dehydroepiandrosterone against aflatoxin B1-and 7,12-dimethylbenz(a)anthracene-induced cytotoxicity and transformation in cultured cells.

1975 • 63 citations

Dehydroepiandrosterone: An anti‐obesity and anti‐carcinogenic agent

1981 • 62 citations

METABOLISM OF SYNTHETIC STEROIDS BY ANIMALS AND MAN

1974 • 60 citations

Metabolism of radioactive 17α-ethynylestradiol by women

1970 • 59 citations

THE RELATION BETWEEN THE URINARY 17-HYDROXYCORTICOSTEROIDS AND 11-DEOXY-17-OXOSTEROIDS AND THE FATE OF PATIENTS AFTER MASTECTOMY

1964 • 59 citations

Physicochemical and genetic evidence for specific antiestrogen binding sites.

1983 • 59 citations

The Isolation from Rabbit Urine of a Conjugate of 17α-Estradiol with N-Acetylglucosamine

1964 • 56 citations

Urinary 17-Ketosteroid Excretion of Women with Advanced Breast Cancer

1968 • 56 citations

Further evidence for the formation of an estrogen-peptide conjugate by rat liver in vitro

1967 • 56 citations

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin papillomas and carcinomas by dehydroepiandrosterone and 3-beta-methylandrost-5-en-17-one in mice.

1985 • 55 citations

Biologic characteristics and chemotherapy of 7,12-dimethylbenz[a]anthracene-induced tumors in rats.

1966 • 54 citations

5-Pregnene-3β,20α-diol-3-sulfate-20- (2'-acetamido-2'-deoxy-α-D-glucoside) and 5-Pregnene-3β,20α-diol-3,20-disulfate. Two Novel Urinary Conjugates^*

1967 • 54 citations

Endocrine Effects of Tamoxifen in Postmenopausal Breast Cancer Patients

1984 • 53 citations

High-dose intravenous metoclopramide versus combination high-dose metoclopramide and intravenous dexamethasone in preventing cisplatin-induced nausea and emesis: a single-blind crossover comparison of antiemetic efficacy.

1985 • 53 citations

Cytotoxicity of estramustine, a steroid-nitrogen mustard derivative, through non-DNA targets.

1983 • 50 citations

Aromatase inhibitors and the treatment of breast cancer

1986 • 49 citations

Induced mammary carcinoma in the female rat as a drug evaluation system.

1966 • 48 citations

THE PREPARATION OF THE CRYSTALLINE FOLLICULAR OVARIAN HORMONE: THEELIN

1930 • 47 citations

IDENTIFICATION OF 3β,21-DIHYDROXY-5-PREGNENE-20-ONE DISULFATE IN HUMAN URINE

1962 • 47 citations

Dexamethasone increases β-adrenoceptor density in human astrocytoma cells

1980 • 46 citations

Androgens in postmenopausal breast cancer: Excretion, production and interaction with estrogens

1975 • 46 citations

Synthesis of steroidal nitrosoureas with antitumor activity

1979 • 44 citations

Identification in Rabbit Urine of the 3-Glucuronoside-17-N-acetylglucosaminide of 17α-Estradiol

1965 • 44 citations

DISPOSITION OF RADIOACTIVE 17α-HYDROXYPROGESTERONE,6α-METHYL-17α-ACETOXYPROGESTERONE AND 6α-METHYLPREDNISOLONE IN HUMAN SUBJECTS*

1961 • 44 citations

Absence of correlation between antiestrogenic activity and binding affinity for the estrogen receptor

1979 • 43 citations

Hormone Changes in Patients with Prostatic Carcinoma, During Treatment with Estramustine Phosphate

1977 • 42 citations

Estrogen-Induced Progesterone Receptor in the Syrian Hamster Kidney. I. Modulation by Antiestrogens and Aindrogens*

1978 • 42 citations

Effect of an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, on 7,12-dimethylbenz[a]anthracene-induced mammary tumors in the rat and its mechanism of action in vivo

1982 • 40 citations

Metabolism of estramustine phosphate (Estracyt ®) in patients with prostatic carcinoma

1981 • 39 citations

Benign and Malignant Breast Disease in South Wales: A Study of Urinary Steroids

1970 • 38 citations

Protein factor that inhibits binding and promotes release of androgen-receptor complex from nuclear chromatin.

1978 • 37 citations

Current Concepts in Breast Cancer.

1968 • 37 citations

Antitumor activity of homo-aza-steroidal esters of [p-[bis(2-chloroethyl)amino]phenyl]acetic acid and [p-[bis(2-chloroethyl)amino]phenyl]butyric acid

1983 • 37 citations

Estrogen receptors in the pancreas

1974 • 37 citations

Chemical and biological aspects of steroid conjugation

1971 • 36 citations

Effects of aromatase inhibitor 4-hydroxyandrostenedione and other compounds in the 7, 12-dimethylbenz(a)anthracene-induced breast carcinoma model.

1982 • 35 citations

A new steroidal alkylating agent with improved activity in advanced murine leukemias

1979 • 35 citations

Human urinary and liver conjugates of 17α-ethynylestradiol

1976 • 35 citations

High Molecular Weight Enzyme Inhibitors. III. Polyestradiol Phosphate, a Long-acting Estrogen.

1958 • 34 citations

Corticosteroid 21-sulphates in human urine

1961 • 33 citations

Effects of tamoxifen, medroxyprogesterone acetate, and their combination on human endometrial estrogen and progestin receptor concentrations, 17β-hydroxysteroid dehydrogenase activity, and serum hormone concentrations

1982 • 33 citations

Studies on the antiprostatic action of estracyt, a nitrogen mustard of estradiol.

1974 • 33 citations

Metabolism of 17α-ethynylestradiol and its 3-methyl ether by the rabbit; An ? ? D-homoannulation

1969 • 33 citations

Fluoxymesterone in the treatment of advanced breast cancer

1957 • 33 citations

Prostatic cancer. I. 6-Methylene-4-pregnen-3-ones as irreversible inhibitors of rat prostatic Δ4-3 ketosteroid 5α-reductase

1981 • 33 citations

Studies on Phenolic Steroids in Human Subjects. XIV. Fate of a Nitrogen Mustard of Estradiol-17β

1975 • 33 citations

On the Presence of "Prostatic Secretion Protein" in Different Species.

1980 • 33 citations

The relationship of cellular structure and function: the matrix system.

1981 • 33 citations

Calusterone (7β,17α-DimethyItestosterone) as Primary and Secondary Therapy of Advanced Breast Cancer

1973 • 32 citations

The steroid alcohol and estrogen sulfotransferases in rodent and human mammary tumors.

1975 • 32 citations

THE DISCRIMINANT FUNCTION IN EARLY CARCINOMA OF THE BREAST

1969 • 30 citations

Estramustine Phosphate Therapy in Carcinoma of the Prostate

1977 • 30 citations

ENDOCRINE PROFILES AND BREAST CANCER

1973 • 30 citations

Influence of sex hormones on prostatic secretion protein, a major protein in rat prostate.

1981 • 29 citations

DIHYDROTESTOSTERONE RECEPTOR IN HUMAN MAMMARY CANCER

1973 • 29 citations

Interaction of androgens with oestradiol-17β receptor proteins in DMBA-induced mammary tumours—a possible oncolytic mechanism

1978 • 29 citations

Interaction of Steroid Hormone Receptors with DNA

1986 • 29 citations

Steroid Hormone Receptors in the Prostate

1979 • 29 citations

First-Pass Metabolism of Ethinyl Estradiol in Dogs and Rats

1981 • 28 citations

Further studies on the anti-neoplastic activity of 3 β-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam {p-[bis(2-chloroethyl)amino]-phenyl}acetate (NSC 290205)

1984 • 27 citations

Antiandrogenic Effects of Spironolactone: Hormonal and Ultrastructural Studies in Dogs and Men

1978 • 26 citations

Methyltrienolone (R1881) is not aromatized by placental microsomes or rat hypothalamic homogenates

1984 • 26 citations

DEHYDROEPIANDROSTERONE IN BLOOD

1959 • 26 citations

Dehydroepiandrosterone in blood. II. Isolation of complexes from human blood plasma containing dehydroepiandrosterone and phosphoric acid.

1959 • 26 citations

Steroid-Protein Interactions

1959 • 26 citations

Pilot Study on the Growth Inhibition by Estramustine Phosphate (Estracyt®) of Rat Mammary Tumours Sensitive and Insensitive to Oestrogen

1979 • 26 citations

Selective inhibition of prostatic tumor 5 alpha-reductase by a 4-methyl-4-azasteroid.

1984 • 26 citations

The absorption metabolism, and excretion of Estracyt (NSC 89199) in patients with prostatic cancer.

1976 • 25 citations

Estramustine Phosphate: Metabolic Aspects Related to Its Action in Prostatic Cancer

1978 • 25 citations

In vitro inhibition of estrogen sulfoconjugation by some 2- and 4-substituted estra-1,3,5(10)-trien-17.beta.-ols

1986 • 25 citations

Hansch analysis of the anabolic activities of some nandrolone esters

1974 • 25 citations

Inhibition by Dexamethasone of Intracellular Binding of Phorbol Esters to Mouse Skin2

1974 • 24 citations

A relationship between estrogen sulfurylation and estrogen and progesterone receptor status in human mammary carcinoma.

1980 • 23 citations

Intermediates in the Transformation of Oral Estradiol

1969 • 23 citations

Adrenal suppression by oral high-dose medroxyprogesterone acetate in breast cancer patients

1984 • 23 citations

Medroxyprogesterone Acetate (MPA) Plasma Levels After Oral and Intramuscular Administration in A Long‐Term Study

1981 • 23 citations

Estramustine phosphate: plasma concentrations of its metabolites following oral administration to man, rat and dog.

1980 • 23 citations

Prostatic cancer—II. Inhibitors of rat prostatic 4-ene-3-ketosteroid 5α-reductase derived from 6-methylene-4-androsten-3-ones

1983 • 23 citations

Antagonism to Estradiol in the Mouse: Reduced Entry of Receptors Complexed with 4-Hydroxytamoxifen into a Mg²⁺-Soluble Chromatin Fraction*

1986 • 22 citations

Progestational activity of 6 alpha-methyl-17 alpha-hydroxyprogesterone acetate.

1958 • 22 citations

Antileukemic effect of homo-aza-steroidal ester of [p-[bis(2-chloroethyl)amino]phenyl]acetic acid.

1977 • 22 citations

Inhibition of prostatic growth in rats by 6-methylene-4-pregnene-3,20-dione

1982 • 22 citations

METABOLISM OF 1-DEHYDROSTEROIDS IN MAN

1958 • 21 citations

EFFECTS OF TAMOXIFEN ON THE BINDING AND METABOLISM OF TESTOSTERONE BY HUMAN PROSTATIC TISSUE AND PLASMA IN VITRO

1979 • 21 citations

Control of Steroid Receptor Levels and Steroid Antagonism

1979 • 21 citations

The Metabolism of Prednisolone by Homogenates of Rat Liver

1958 • 21 citations

Potential steroidal antiestrogens

1977 • 21 citations

Inhibition of androgen aromatization in human breast cancer

1980 • 19 citations

Retardation of Prostate Tumor Progression in the Noble Rat by 4-Methyl-4-aza-steroidal Inhibitors of 5α-Reductase<xref ref-type="fn" rid="FN2">2</xref>

1985 • 19 citations

PROGESTATIONAL ACTIVITY OF 6α-METHYL-17α-HYDROXYPROGESTERONE ACETATE

1958 • 19 citations

Effects of 17-alpha-thioestradiol, 2 estradiol analogs, and 2 androgens on 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors.

1966 • 19 citations

Ring-a reduction of medroxyprogesterone acetate [17α-acetoxy-6α-methyl-4-pregnene-3, 20-dione (MPA)] in biological systems

1980 • 19 citations

Medroxyprogesterone acetate (MAP) relative bioavailability after single high-dose administration in cancer patients.

1982 • 19 citations

Tamoxifen, aminoglutethimide and danazol: effect of therapy on hormones in post-menopausal patients with breast cancer

1982 • 18 citations

Plasma half-life, tissue distribution, and excretion of triamcinolone-H3.

1961 • 18 citations

Biological Characterization of Human Tumours

1965 • 18 citations

Steroids and steroidases. 10. Potentially antitumor active androstane compounds containing C-17 nitrogen mustard functions

1971 • 18 citations

Distribution and metabolism of prednisone in mice, dogs, and monkeys.

1977 • 18 citations

Prostatic binding of estradiol-17β in the baboon

1978 • 18 citations

Urinary steroid values as a guide to prognosis in breast cancer.

1968 • 17 citations

Some adenine and adenosine methylene-bridged estrogens

1983 • 17 citations

Combination metoclopramide and dexamethasone: an effective antiemetic regimen in outpatients receiving non-cisplatin chemotherapy.

1984 • 17 citations

The effect of stanolone in the treatment of advanced breast cancer

1955 • 16 citations

DEHYDROEPIANDROSTERONE IN BLOOD

1958 • 16 citations

Estramustine affects bone mineral metabolism in metastatic prostate cancer

1986 • 16 citations

NEW METABOLIC CONJUGATES OF STEROIDS

1970 • 16 citations

Dehydroepiandrosterone in blood. I. Cleavage of dehydroepiandrosterone conjugates by phosphatases.

1958 • 15 citations

The effect of dexamethasone on vascular permeability of experimental brain tumours

1986 • 15 citations

Circulating sex steroids and sex hormone binding globulin in pancreatic adenocarcinoma.

1986 • 15 citations

Multiple steroid hormone receptors in calf uterus. Binding specificities and distribution.

1972 • 15 citations

Catechol estrogens of the 1,1,2-triphenyl-1-butene type. Relationship between structure, estradiol receptor affinity, estrogenic and antiestrogenic properties, and mammary tumor inhibiting activities

1986 • 15 citations

Androgen Control of Cytosol Progesterone Receptor Levels in the MT-W9B Transplantable Mammary Tumor in the Rat<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 15 citations

Relationship of glutathione depletion and inhibition of glutathione-S-transferase activity to the antimitotic properties of estramustine.

1986 • 15 citations

Effects of Diethylstilbestrol and Estramustine Phosphate (Estracyt) on Lymphoid Cell Populations and Mitogen Responsiveness in Male Mice

1982 • 15 citations

Glucocorticoid actions on lymphoid tissue and the immune system: physiologic and therapeutic implications.

1984 • 15 citations

Binding of estramustine, a nitrogen mustard derivative of estradiol-17 beta, in cytosol from rat ventral prostate.

1978 • 15 citations

Endocrine and Cytotoxic Therapy

1981 • 14 citations

Studies of Antiprostatic Agents in the Baboon

1974 • 14 citations

Effect of tamoxifen treatment on cortisol metabolism and the course of the disease in advanced breast cancer

1981 • 13 citations

Some Metabolic Aspects of a Nitrogen Mustard of Prednisolone

1978 • 13 citations

Histochemical and ultrastructural study of prostatic tissue from baboons treated with antiprostatic drugs.

1976 • 13 citations

3,17.beta.-dihydroxy-20,21-epoxy-19-norpregna-1,3,5(10)-trienes. Synthesis, rearrangement, cytotoxicity, and estrogen-receptor binding

1986 • 13 citations

The value of urine steroid hormone assays in breastcancer

1967 • 13 citations

Design of cytotoxic steroids for prostate cancer

1986 • 13 citations

The metabolic fate of chlormadinone acetate in the baboon

1976 • 13 citations

Syntheses and biological activities of 7.beta.-methyl steroids

1979 • 13 citations

Criteria for evaluating hormones in the 7,12-dimethylbenz[a]-anthracene-induced mammary tumor-rat experimental chemotherapy system.

1968 • 13 citations

Pharmacology and clinical studies with RU 23908 (Anandron).

1985 • 13 citations

Effect of tamoxifen on steroid hormone receptors and creatine kinase activity in human endometrial carcinoma

1986 • 12 citations

Estracyt (NSC 89199) as a substrate for phosphatases in human serum.

1974 • 12 citations

Metabolism of ethynyloestradiol and oestradiol in the guinea-pig

1975 • 12 citations

Synthesis and cytotoxic activity of estrogen α-methylene-δ-lactones

1984 • 12 citations

Biochemical basis of breast cancer treatment by androgens and progestins.

1984 • 12 citations

In Vivoandin VitroConjugation and Metabolism of Estrogens by the Baboon Kidney

1976 • 12 citations

Sex Hormone Binding Globulin and Transcortin in Human and Baboon Males

1978 • 11 citations

ESTRADURIN (POLYOESTRADIOL PHOSPHATE) IN THE TREATMENT OF PROSTATIC CARCINOMA. A CLINICAL AND STEROID METABOLIC STUDY.

1963 • 11 citations

ESTRADURIN(R) (POLYOESTRADIOL PHOSPHATE1) IN THE TREATMENT OF PROSTATIC CARCINOMA.

1963 • 11 citations

Effects of 4-nitroestrone 3-methyl ether on dimethylbenz(a)anthracene-induced mammary tumors.

1983 • 11 citations

Effect of a Spirolactone on Plasma and Urinary Aldosterone in Primary Aldosteronism

1977 • 10 citations

Modified steroid hormones. 7. 4-Fluoro-17.beta.-estradiol:carbon-13 nuclear magnetic resonance, crystal and molecular structure, and biological activity

1983 • 10 citations

Radioimmunoassay of estramustine phosphate in plasma.

1978 • 10 citations

Medroxyprogesterone acetate release from Silastic devices as replacement for local irradiation by radium tubes in preoperative intrauterine packing for endometrial adenocarcinoma

1977 • 10 citations

Cytostatic activity of steroid linked nitrosoureas

1984 • 10 citations

Synthesis and biological activity of some ethers of testosterone. Implications concerning the biological activity of esters of testosterone

1975 • 10 citations

Binding of Dexamethasone by The Subcellular Fractions of Mouse Epidermis and Dermis

1977 • 9 citations

Metabolism of 17beta-estradiol during receptor-mediated nuclear migration in breast cancer cells.

1978 • 9 citations

INFLUENCE OF ANTIOESTROGENS ON SPECIFIC BINDING OF [3 H]OESTRADIOL IN VITRO BY NUCLEI FROM RAT MAMMARY TUMOURS

1975 • 9 citations

Synthesis and Evaluation of Novel N-Substituted N′-(3-Hydroxy-17-oxoestra-1,3,5(10)-trien-2- and -4-yl)thiourea Derivatives for Binding to the Estrogen Receptor and Cytotoxic Activity on MCF-7 cells

1984 • 9 citations

Effect of estramustine phosphate (Estracyt�) on transplantable mouse tumours

1979 • 8 citations

Estramustine. Metabolic pattern and possible mechanisms for its action in prostate cancer.

1979 • 8 citations

Antitumor effect of two oral steroids, mepitiostane and fluoxymesterone, on a pregnancy-dependent mouse mammary tumor (TPDMT-4).

1977 • 8 citations

Proceedings of the 1987 Laurentian Hormone Conference

1988 • 8 citations

Estrone receptor formation during the processing of estradiol-receptor complex in MCF-7 cells.

1982 • 7 citations

Hormonal receptors in human neoplasia.

1980 • 6 citations

Androgen metabolism in the baboon: A comparison with the human

1978 • 6 citations

Biochemical assays for the selection of cytotoxic-linked estrogens with potential therapeutic activity.

1978 • 6 citations

ChemInform Abstract: In vitro Inhibition of Estrogen Sulfoconjugation by Some 2‐ and 4‐Substituted Estra‐ 1,3,5(10)‐trien‐17β‐ols.

1986 • 5 citations

METABOLIC CONJUGATION AND HYDROLYSIS OF ESTROGENS AND PROGESTERONE IN THE ENTEROHEPATIC CIRCULATION

1970 • 5 citations

The Isolation of Steroid Conjugates

1970 • 5 citations

Relative affinities of estramustine phosphate metabolites to the cytosol oestrogen receptor of rat testis

1986 • 5 citations

Prednisolone Plasma Levels after Oral Administration of Prednimustine®

1981 • 5 citations

Medroxyprogesteronacetat in hoher Dosierung beim metastasierenden Mammakarzinom

1982 • 4 citations

The synthesis of 3H labelled steroid-nitrogen mustard derivatives and studies on their action in rat and human prostate

1982 • 4 citations

Antitumour Activity, Toxicity and Disposition of LS 1727, a Nitroso‐Chloroethyl Carbamate of 19‐Nortestosterone, in Rats and Mice

1981 • 3 citations

ChemInform Abstract: ANTITUMOR ACTIVITY OF STEROIDAL CARBAMATE DERIVATIVES FROM N,N‐BIS(2‐CHLOROETHYL)‐P‐PHENYLENEDIAMINE

1981 • 3 citations

Interaction of the cytotoxic agent estramustine phosphate (Estracyt) with the estrogen receptor of the human uterus

1979 • 3 citations

In vitro synergism between estrogens and cytotoxic agents

1985 • 3 citations

New forms and future perspectives in endocrine treatment of prostatic carcinoma.

1984 • 3 citations

Preliminary clinical study of prednimustine in lung cancer.

1977 • 3 citations

Hyperlipoproteinämie bei additiver Behandlung des metastasierenden Mammakarzinoms mit Metenolonönanthat

2008 • 2 citations

Medroxyprogesteronacetat als Glucocorticoid in der Kombination mit Aminoglutethimid zur Therapie des metastasierenden Mammakarzinoms

1982 • 2 citations

Evaluation of 4-Androstene-3β,17β-diol Diacetate in the Treatment of Advanced Breast Cancer

1960 • 2 citations

On the function of hormone receptors in the action of steroidal alkylating agents

1977 • 1 citations

ChemInform Abstract: ANTINEOPLASTIC AGENTS. 17β‐P‐(N,N‐BIS(CHLOROETHYL)AMINO)PHENYLACETATES OF STEROIDAL RING A UNSATURATED LACTAMS

1983 • 1 citations

Hypothesis concerning the mechanism of action of some new alkylating agents from synthetic estrogens.

1966 • 1 citations

Deleted Work

1955 • 0 citations