Progestin Action and Progesterone Receptor Structure in Human Breast Cancer: A Review

Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells

1984 • 1,416 citations

ON THE TREATMENT OF INOPERABLE CASES OF CARCINOMA OF THE MAMMA: SUGGESTIONS FOR A NEW METHOD OF TREATMENT, WITH ILLUSTRATIVE CASES.1

1896 • 1,240 citations

Serum-free cell culture: a unifying approach

1980 • 964 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Nuclear localization of unoccupied oestrogen receptors

1984 • 882 citations

Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor.

1978 • 797 citations

The value of estrogen and progesterone receptors in the treatment of breast cancer

1980 • 735 citations

Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line

1982 • 727 citations

Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells

1975 • 663 citations

Establishment and characterization of a cell line of human breast carcinoma origin

1979 • 653 citations

Predicting Response to Endocrine Therapy in Human Breast Cancer: A Hypothesis

1975 • 570 citations

Monoclonal antibodies to human estrogen receptor.

1980 • 545 citations

Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones

1984 • 442 citations

Estrogen Control of Progesterone Receptor in Human Breast Cancer: Role of Estradiol and Antiestrogen*

1978 • 407 citations

RAPID INDUCTION OF MAMMARY CARCINOMA IN THE RAT AND THE INFLUENCE OF HORMONES ON THE TUMORS

1959 • 376 citations

Progesterone Receptors as a Prognostic Factor in Stage II Breast Cancer

1983 • 372 citations

Nuclear mechanisms of estrogen action. Effects of estradiol and anti-estrogens on estrogen receptors and nuclear receptor processing.

1978 • 348 citations

Steroid receptor analyses of nine human breast cancer cell lines.

1978 • 300 citations

Chicken oviduct progesterone receptor: Location of specific regions of high-affinity binding in cloned DNA fragments of hormone-responsive genes

1982 • 256 citations

Phosphorylation-induced mobility shift in phospholamban in sodium dodecyl sulfate-polyacrylamide gels. Evidence for a protein structure consisting of multiple identical phosphorylatable subunits.

1984 • 254 citations

Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance

1982 • 249 citations

In SituPhotolinked Nuclear Progesterone Receptors of Human Breast Cancer Cells: Subunit Molecular Weights after Transformation and Translocation*

1983 • 238 citations

Androgen Receptor Assay with [³H]Methyltrienolone (R1881) in the Presence of Progesterone Receptors*

1979 • 223 citations

Monoclonal antibodies to estrophilin: probes for the study of estrogen receptors.

1980 • 208 citations

Structure, dissociation, and proteolysis of mammalian steroid receptors. Multiplicity of glucocorticoid receptor forms and proteolytic enzymes in rat liver and kidney cytosols.

1983 • 197 citations

Progesterone and progestins

1983 • 196 citations

Dexamethasone 21-mesylate: an affinity label of glucocorticoid receptors from rat hepatoma tissue culture cells.

1981 • 190 citations

Specific progesterone receptors in human breast cancer

1975 • 188 citations

Monoclonal antibodies against the rat liver glucocorticoid receptor.

1984 • 188 citations

Structure of Mammalian Steroid Receptors: Evolving Concepts and Methodological Developments

1984 • 188 citations

EXTINCTION OF EXPERIMENTAL MAMMARY CANCER, I. ESTRADIOL-17β AND PROGESTERONE

1962 • 185 citations

Immunochemical analysis of the glucocorticoid receptor: identification of a third domain separate from the steroid-binding and DNA-binding domains.

1982 • 178 citations

Estrogens Stimulate Cell Proliferation and Induce Secretory Proteins in a Human Breast Cancer Cell Line (T₄₇D)*

1982 • 175 citations

Growth of a human mammary tumour cell line in a serum-free medium

1979 • 174 citations

Antiestrogenic Effect of R5020, a Synthetic Progestin in Human Breast Cancer Cells in Culture*

1983 • 173 citations

Evidence that dephosphorylation inactivates glucocorticoid receptors.

1977 • 170 citations

Receptors from Glucocorticoid-Sensitive Lymphoma Cells and Two Classes of Insensitive Clones: Physical and DNA-Binding Properties

1974 • 166 citations

Quantum yield of acridines interacting with DNA of defined base sequence

1972 • 160 citations

Relationship of presence of progesterone receptors to prognosis in early breast cancer.

1980 • 156 citations

Heterogeneity of estrogen receptors in the cytosol and nuclear fractions of the rat uterus

1978 • 156 citations

Efficient and highly selective covalent labeling of the estrogen receptor with [3H]tamoxifen aziridine.

1983 • 154 citations

Effects of Molybdate and Endogenous Inhibitors on Steroid-Receptor Inactivation, Transformation, and Translocation

1984 • 153 citations

Hormones, Receptors and Breast Cancer

1979 • 150 citations

Subunit dissociation as a possible mechanism of glucocorticoid receptor activation

1983 • 150 citations

DNA sequence preference of the progesterone receptor.

1983 • 150 citations

Preferential inhibition by 5-bromodeoxyuridine of the synthesis of tyrosine aminotransferase in hepatoma cell cultures

1971 • 148 citations

Monoclonal antibodies to rabbit progesterone receptor: crossreaction with other mammalian progesterone receptors.

1983 • 145 citations

The Subunit Structure of Human Breast Cancer Progesterone Receptors: Characterization by Chromatography and Photoaffinity Labeling*

1983 • 142 citations

Growth inhibition and increase of insulin receptors in antiestrogen-resistant T47DCO human breast cancer cells by progestins: implications for endocrine therapies.

1985 • 141 citations

Phosphorylation in vivo of chicken oviduct progesterone receptor.

1982 • 138 citations

Effects of serum and insulin on the sensitivity of the human breast cancer cell line MCF-7 to estrogen and antiestrogens.

1981 • 138 citations

Promoter Elements of Genes Coding for Proteins and Modulation of Transcription by Estrogens and Progesterone

1984 • 133 citations

Growth of a human breast cancer cell line in serum-free hormone-supplemented medium.

1978 • 130 citations

Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU 486, a new anti-glucocorticosteroid of high affinity for the glucocorticosteroid receptor

1983 • 125 citations

Effects of proteases and protease inhibitors on the 4.5 S and 8 S androgen receptor.

1979 • 125 citations

Studies on the Structure and Function of the Chicken Progesterone Receptor

1981 • 124 citations

Butyrate and related inhibitors of histone deacetylation block the induction of egg white genes by steroid hormones

1980 • 118 citations

Photoaffinity labeling of glucocorticoid receptors.

1981 • 117 citations

How do genome-regulatory proteins locate their DNA target sites?

1982 • 117 citations

Increase of progesterone receptor by tamoxifen as a hormonal challenge test in breast cancer.

1980 • 116 citations

Progesterone and progesterone receptors in experimental breast cancer.

1977 • 115 citations

Covalent attachment of a progestational steroid to chick oviduct progesterone receptor by photoaffinity labelling

1980 • 114 citations

Phosphorylation of hen progesterone receptor by cAMP dependent protein kinase

1981 • 112 citations

Estrogen, androgen, glucocorticoid, and progesterone receptors in progestin-induced regression of human breast cancer.

1980 • 103 citations

Affinity labeling of the rat liver glucocorticoid receptor with dexamethasone 21-mesylate. Identification of covalently labeled receptor by immunochemical methods.

1981 • 101 citations

Thyroid hormone nuclear receptor levels are influenced by the acetylation of chromatin-associated proteins.

1980 • 100 citations

Characterization of the Estrogen Receptor and Its Dynamics in MCF-7 Human Breast Cancer Cells Using a Covalently Attaching Antiestrogen*

1984 • 98 citations

Control of insulin receptor level in 3T3 cells: effect of insulin-induced down-regulation and dexamethasone-induced up-regulation on rate of receptor inactivation.

1982 • 96 citations

Inactivation of oestrogen receptor in vitro by nuclear dephosphorylation

1981 • 93 citations

Purification and characterization of estrogen-binding proteins from calf uterus. 4. Estrogen-binding proteins of calf uterus. Purification to homogeneity of receptor from cytosol by affinity chromatography

1979 • 93 citations

Estrogen and progesterone receptors in the prediction of response of breast cancer to endocrine therapy

1980 • 92 citations

Monoclonal antibodies against estrogen receptor: interaction with different molecular forms and functions of the receptor

1982 • 92 citations

The role of progesterone receptors in the management of advanced breast cancer

1980 • 92 citations

Purification of "nontransformed" avian progesterone receptor and preliminary characterization.

1982 • 90 citations

Progesterone Receptors of Chick Oviduct

1974 • 90 citations

Actinomycin D prevents nuclear processing of estrogen receptor.

1978 • 85 citations

Progesterone Receptor from Chick Oviduct:. Purification of Molybdate-Stabilized Form and Preliminary Characterization

1982 • 85 citations

Chemotherapy versus combination of chemotherapy and endocrine therapy in advanced breast cancer: A prospective randomized study

1983 • 84 citations

Treatment of Breast Cancer with Medroxyprogesterone Acetate

1968 • 81 citations

Differences between estrogen- and antiestrogen-estrogen receptor complexes from human breast tumors identified with an antibody raised against the estrogen receptor.

1984 • 79 citations

Nuclear estrogen receptors. Effect of inhibitors on processing and steady state levels.

1980 • 78 citations

Dual effects of the progestin R5020 on proteins released by the T47D human breast cancer cells.

1984 • 75 citations

Control of Hormone Receptor Levels and Growth of 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors by Estrogens, Progesterone and Prolactin

1977 • 74 citations

Combined chemo- and hormonal therapy in advanced breast cancer

1977 • 74 citations

Randomized clinical trial of megestrol acetate versus tamoxifen in paramenopausal or castrated women with advanced breast cancer

1982 • 72 citations

Assessment of structural similarities in chick oviduct progesterone receptor subunits by partial proteolysis of photoaffinity-labeled proteins.

1983 • 71 citations

Treatment of metastatic breast cancer patients with different dosages of megestrol acetate; dose relations, metabolic and endocrine effects

1984 • 71 citations

Progestin therapy in advanced breast cancer: Megestrol acetate—an evaluation of 160 treated cases

1980 • 70 citations

Photoaffinity labeling of the chick progesterone receptor proteins. Similar hormone binding domains detected after removal of proteolytic interference.

1983 • 69 citations

Characterization of an antiserum against the glucocorticoid receptor

1981 • 69 citations

Prognostic value of estrogen and progesterone receptors in primary breast cancer

1983 • 67 citations

Phosphorylation of purified glucocorticoid receptor from rat liver by an endogenous protein kinase

1984 • 66 citations

Prolactin and progesterone effect on specific estradiol binding in uterine and mammary tissues invitro

1973 • 64 citations

Treatment of advanced breast cancer with megestrol acetate after therapy with tamoxifen

1982 • 63 citations

An antiserum to the rat liver glucocorticoid receptor.

1980 • 63 citations

Calf uterine estradiol receptor. Effects of molybdate on salt-induced transformation process and characterization of a nontransformed receptor state.

1981 • 63 citations

Monoclonal antibody to chicken oviduct progesterone receptor.

1983 • 61 citations

Protein kinase activity of purified components of the chicken oviduct progesterone receptor

1983 • 61 citations

Antibodies to rabbit progesterone receptor: crossreaction with human receptor.

1981 • 61 citations

Characterization of two 8 S forms of chick oviduct progesterone receptor.

1982 • 59 citations

Selective binding of chicken progesterone receptor a subunit to a DNA fragment containing ovalbumin gene sequences

1982 • 59 citations

Evidence that estrogen-receptor-negative, progesterone-receptor-positive breast and ovarian carcinomas contain estrogen receptor

1981 • 57 citations

Effects of Multiple Pituitary Homografts or Progesterone on 7,12-Dimethylbenz[<italic>a</italic>]anthracene-lnduced Mammary Tumors in Rats<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1968 • 57 citations

Alteration of cell shape, adhesion, and lipid accumulation in human breast cancer cells (T-47D) by human prolactin and growth hormone.

1984 • 55 citations

Direct inhibition of growth and antagonism of insulin action by glucocorticoids in human breast cancer cells in culture.

1979 • 55 citations

Dibromodulcitol and Adriamycin ± tamoxifen in advanced breast cancer*

1982 • 55 citations

Progesterone receptors in human breast cancer. Stoichiometric translocation and nuclear receptor processing.

1983 • 55 citations

Steroid receptors and prognosis in operable (stage I and II) breast cancer

1983 • 55 citations

Antibodies against highly purified b-subunit of the chick oviduct progesterone receptor

1984 • 54 citations

Effects of tamoxifen on estrogen and progesterone receptors in human breast cancer.

1981 • 53 citations

Immunohistochemical localization of estrogen receptors in human mammary carcinoma using antibodies to the receptor protein

1982 • 52 citations

High-dose medroxyprogesterone acetate in breast cancer resistant to endocrine and cytotoxic therapy

1979 • 52 citations

Effects of progesterone on 9,10-dimethyl-1,2-benzanthracene-induced mammary tumours in Sprague-Dawley rats.

1967 • 52 citations

Putative androgen receptors distinguished in wild-type and testicular-feminized (Tfm) mice

1979 • 51 citations

Antibodies to estrophilin: Comparison between rabbit and goat antisera

1979 • 50 citations

Progesterone receptor replenishment in T47D human breast cancer cells. Roles of protein synthesis and hormone metabolism.

1983 • 50 citations

The value of progesterone receptor assays in the management of advanced breast cancer

1980 • 50 citations

Direct evidence of in vitro phosphorylation-dephosphorylation of the estradiol-17β receptor. role of Ca2+-Calmodulin in the activation of hormone binding sites

1984 • 49 citations

Antibodies against Progesterone Receptor from Chick Oviduct. Cross-Reactivity with Mammalian Progesterone Receptors

1982 • 48 citations

Inactivation of chick oviduct progesterone receptors

1980 • 48 citations

Evidence for two structurally related progesterone receptors in chick oviduct cytosol

1983 • 47 citations

The quaternary structure of carp muscle alkaline protease

1980 • 46 citations

Progesterone-binding sites of the chick oviduct receptor. Presence of a weaker ligand site which is destroyed by phosphatase treatment.

1984 • 45 citations

Purification of glucocorticoid receptors from rat liver cytosol. Preparation of antibodies against the major receptor proteins and application of immunological techniques to study activation and translocation

1979 • 44 citations

Progesterone receptor subunits are high-affinity substrates for phosphorylation by epidermal growth factor receptor.

1984 • 44 citations

Combined cytotoxic and progestogen therapy for advanced breast cancer

1978 • 44 citations

Purification of a human progesterone receptor

1981 • 44 citations

Chemical cross-linking of chick oviduct progesterone-receptor subunits by using a reversible bifunctional cross-linking agent

1979 • 43 citations

The clinical value of multiple steroid receptor assays in breast cancer management

1980 • 42 citations

Characterization of Different Forms of the Androgen Receptor*

1979 • 42 citations

Isolation and Characterization of the Estrogen Receptor in Hen Oviduct: Evidence for Two Molecular Species*

1980 • 42 citations

Role of medroxyprogesterone in endocrine-related tumors

1980 • 42 citations

A clinical trial of megestrol acetate in advanced breast cancer

1974 • 42 citations

Estrogen receptor has enhanced affinity for bromodeoxyuridine-substituted DNA.

1978 • 41 citations

Reduction of carcinogen-induced mammary cancer incidence in rats by early treatment with hormones or drugs.

1974 • 40 citations

Analysis of estradiol and progesterone receptors in early and advanced breast tumors

1980 • 40 citations

The Effect of Synthetic Corticosteroids on Ovarian Function in the Baboon

1972 • 40 citations

Chick oviduct progesterone receptor: structure, immunology, function

1984 • 39 citations

The putative molybdate-stabilized progesterone receptor subunit is not a steroid-binding protein.

1984 • 39 citations

Structural analysis of chicken oviduct progesterone receptor using monoclonal antibodies to the subunit B protein

1984 • 39 citations

Relationship between steroid receptors and response to endocrine therapy and cytotoxic chemotherapy in metastatic breast cancer

1980 • 38 citations

The use of intercalating dye molecules in the study of chromatin structure

1974 • 37 citations

Effect of increasing doses of estrogen and progesterone on mammary carcinogenesis in the rat

1973 • 37 citations

Clinical trial of Δ1-testololactone (NSC 23759), medroxy progesterone acetate (NSC 26386) and oxylone acetate (NSC 47438) in advanced female mammary cancer:A report of the cooperative breast cancer group

1969 • 37 citations

A monoclonal antibody to the estrogen receptor discriminates between the inactivated and activated estrogen- and anti-estrogen-receptor complexes

1984 • 35 citations

MONOCLONAL ANTIBODIES TO THE GLUCOCORTICOID RECEPTOR

1982 • 35 citations

Evidence that invivo estradiol receptor translocated into nuclei is dephosphorylated and released into cytoplasm

1982 • 35 citations

Further clinical studies with megestrol acetate in advanced breast cancer

1976 • 33 citations

Affinity chromatography of estrogen receptors on diethylstilbestrol-agarose

1984 • 33 citations

³PURIFICATION OF AN ESTROGEN-REGULATED BREAST CANCER PROTEIN BY MONOCLONAL ANTIBODY AFFINITY CHROMATOGRAPHY

1983 • 33 citations

High Dose Medroxyprogesterone-Acetate Treatment in Advanced Mammary Carcinoma: A Phase II Investigation

1978 • 33 citations

Estrogen-Insensitive Progesterone Receptors in a Human Breast Cancer Cell Line: Characterization of Receptors and of a Ligand Exchange Assay*

1982 • 32 citations

Progesterone-specific stimulation of triglyceride biosynthesis in a breast cancer cell line (T-47D).

1983 • 31 citations

Mitomycin-C and megestrol acetate in treatment of breast cancer refractory to hormonal and combination chemotherapy

1978 • 27 citations

Oral high-dose medroxyprogesterone acetate (MAP) in treatment of advanced breast cancer

1981 • 27 citations

Comparison of sex steroid receptor analyses and carcinoembryonic antigen with clinical response to hormone therapy

1980 • 27 citations

Physicochemical Characterization of the Androgen Receptor in Rat Uterine Cytosol*

1983 • 27 citations

Isoelectric Focusing of Androgen Receptors from Wild-type and Tfm Mouse Kidneys*

1981 • 26 citations

Characterization of the glucocorticoid receptor. Comparison of wild type and variant receptors.

1984 • 25 citations

Molecular cloning of a cDNA for the chicken progesterone receptor B antigen.

1984 • 24 citations

Cyclic Nucleotide Concentrations in 7,12-Dimethylbenz[a]anthracene-Induced Pancreatic Cancer in Rats2

1978 • 24 citations

Differences in Nuclear Glucocorticoid Binding Between Corticoid-Sensitive and Corticoid-Resistant Lymphocytes of Mouse Lymphoma P1798 and Stabilization of Nuclear Hormone Receptor Complexes With Carbobenzoxy-L-phenylalanine<xref ref-type="fn" rid="FN2">2</xref>

1978 • 23 citations

Interaction of [3H] estradiol — and [3H] monohydroxytamoxifen-estrogen receptor complexes with a monoclonal antibody

1983 • 22 citations

Analysis of chicken progesterone receptor structure using a spontaneous sheep antibody

1981 • 22 citations

Heterogeneous Deoxyribonucleic Acid-Binding Forms of Rabbit Uterine Progesterone Receptor*

1984 • 21 citations

Effect of Antibodies to Estrogen Receptor on the Binding of³H-Labeled Antiestrogens and Androstanediol in the Uterus*

1982 • 21 citations

Progestin-specific markers in human cell lines: biological and pharmacological applications

1984 • 20 citations

Syrian hamster glucocorticoid receptors. Characteristics of binding of partially purified receptor to DNA.

1983 • 20 citations

AFFINITY LABELLING OF THE HUMAN UTERINE PROGESTERONE RECEPTOR WITH 21-, 16α- AND llα-BROMOACETOXYPROGESTERONES.*

1981 • 20 citations

Norethisterone acetate (SH420) in advanced breast cancer

1973 • 19 citations

Antibodies to estradiol receptor from human myometrium

1981 • 18 citations

Steroid receptors and response to endocrine treatment and chemotherapy of advanced breast cancer

1980 • 17 citations

An insulin effect on cytoplasmic estrogen receptor in the human breast cancer cell line MCF-7.

1981 • 17 citations

Oestrogen and progesterone receptors and response to endocrine therapy in Japanese breast cancer

1980 • 16 citations

Effects of progesterone administration on N-nitrosomethylurea-induced rat mammary carcinogenesis

1983 • 15 citations

5-Bromodeoxyuridine Specifically Inhibits the Synthesis of Estrogen-Induced Proteins in MCF7 Cells

1981 • 15 citations

Growth regulation of two rat adenocarcinoma cell lines by dexamethasone and progesterone

1981 • 14 citations

Norethisterone acetate in the treatment of advanced breast cancer

1976 • 14 citations

Estrogen stimulates cell proliferation and the increase of a 52,000 dalton glycoprotein in human breast cancer cells

1984 • 13 citations

The general validity of the subunit model of the progesterone receptor from chick oviduct appears questionable

1980 • 13 citations

Combination therapy with progestins and tamoxifen in advanced breast cancer: A preliminary report.

1982 • 12 citations

Effects of progesterone on mammary carcinogenesis by DMBA applied directly to rat mammae

1979 • 12 citations

261 Sequential vs. simultaneous administration of tamoxifen and medroxy progesterone acetate in advanced breast cancer

1983 • 11 citations

PROGESTAGENS AND ADVANCED BREAST CANCER

1971 • 10 citations

Predicting treatment response in breast cancer using urinary discriminant ratio and receptor assay

1981 • 10 citations

PURIFICATION OF THE CYTOPLASMIC OESTROGEN RECEPTOR FROM MAMMARY TUMOURS INDUCED IN RATS WITH DIMETHYLBENZANTHRACENE

1979 • 9 citations

Immunoreactivity of the core of estrogen receptors found in different subcellular compartments of target cells from a variety of mammalian species

1983 • 9 citations

An Autoradiographic Study of the Early Effects of 7,12-Dimethylbenz(a)anthracene and Progesterone on DNA Synthesis in Rat Mammary Epithelial Cells and Subsequent Tumour Development

1972 • 8 citations

Estradiol and progesterone receptors content and response to norethisterone treatment in advanced breast cancer

1982 • 8 citations

Combination therapy with progestins and tamoxifen in advanced breast cancer

1982 • 8 citations

Kombinierte Chemo-Antiöstrogen-Therapie beim metastasierten Mammakarzinom: Eine randomisierte Vergleichsstudie zwischen AVC und AVC plus Tamoxifen

2008 • 7 citations

260 Treatment of advanced breastcancer with tamoxifen after megestrol acetate therapy and vice versa, a retrospective study

1983 • 5 citations

259 Oral high-dose medroxyprogesterone acetate versus tamoxifen in advanced postmenopausal breast cancer and cross-over effect

1983 • 4 citations

254 Myeloprotective effect of high dose medroxyprogresteron acetate (MPA)

1983 • 4 citations