Differentiation of opiate and neuroleptic receptor binding in rat brain

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

A Reëxamination of the Hammett Equation.

1953 • 2,102 citations

A New Substituent Constant, π, Derived from Partition Coefficients

1964 • 1,353 citations

Aromatic substituent constants for structure-activity correlations

1973 • 1,189 citations

Steric effects in organic chemistry

1957 • 1,102 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

A Mathematical Contribution to Structure-Activity Studies

1964 • 913 citations

Brain receptors for antipsychotic drugs and dopamine: direct binding assays.

1975 • 695 citations

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

1973 • 650 citations

Opiate Receptor Binding of Agonists and Antagonists Affected Differentially by Sodium

1974 • 554 citations

The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats.

1963 • 537 citations

Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain

1973 • 527 citations

Stereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse Brain

1971 • 413 citations

Physical Organic Chemistry

2005 • 409 citations

Dopamine receptor binding: Differentiation of agonist and antagonist states with 3H-dopamine and 3H-haloperidol

1975 • 390 citations

IS IT POSSIBLE TO PREDICT THE CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA?I. "NEUROLEPTIC ACTIVITY SPECTRA" FOR RATS.

1965 • 348 citations

Neurotransmitter Receptors in the Brain: Biochemical Identification

1976 • 186 citations

Further properties of stereospecific opiate binding sites in rat brain: on the nature of the sodium effect.

1975 • 186 citations

Apomorphine: Chemistry, Pharmacology, Biochemistry

1976 • 127 citations

Sufentanil, a very potent and extremely safe intravenous morphine-like compound in mice, rats and dogs.

1976 • 120 citations

Stereospecific binding of narcotics to brain cerebrosides

1974 • 111 citations

N-4-Substituted 1-(2-arylethyl)-4-piperidinyl-N-phenylpropanamides, a novel series of extremely potent analgesics with unusually high safety margin.

1976 • 108 citations

Butyrophenone influences on the opiate receptor

1976 • 94 citations

Differential distribution of opiate and neuroleptic receptors and dopamine-sensitive adenylate cyclase in rat brain

1977 • 87 citations

Physical Organic Chemistry

1966 • 63 citations

Haloperidol binding to an opiate receptor site

1975 • 61 citations

Stereospecific morphine adsorption to phosphatidyl serine and other membranous components of brain

1975 • 55 citations

Homologous N-alkylnorketobemidones. Correlation of receptor binding with analgesic potency

1975 • 43 citations

Predictability of correlations between in vitro tetracycline potencies and substituent indices

1970 • 43 citations

Some electronic factors in drug-receptor interactions

1968 • 33 citations

The Apomorphine Antagonism Test in Dogs

1971 • 29 citations

Limiting factors in the antagonism of neuroleptics on dopamine-sensitive adenylate cyclase

1976 • 28 citations

Analysis of biological linear free-energy relations

1969 • 19 citations

Discrimination of narcotic drugs on 3H-fentanyl receptor binding.

1976 • 8 citations

Correlation of the potencies of tetracyclines in vitro with a d-ring substituent index.

1970 • 8 citations

Morphine and codeine. The analgesic effect in tolerant and non-tolerant rats.

1967 • 8 citations