The mechanisms of action of L-dopa in Parkinson's disease

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

Verteilung Von Noradrenalin Und Dopamin (3-Hydroxytyramin) Im Gehirn Des Menschen Und Ihr Verhalten Bei Erkrankungen Des Extrapyramidalen Systems

1960 • 1,863 citations

Dopamine (3-hydroxytyramine) and brain function.

1966 • 1,401 citations

Modification of Parkinsonism — Chronic Treatment with L-Dopa

1969 • 1,253 citations

On the Presence of 3-Hydroxytyramine in Brain

1958 • 632 citations

A Quantitative Study on the Nigro‐Neostriatal Dopamine Neuron System in the Rat

1966 • 374 citations

Hyperactivity of Remaining Dopaminergic Neurones after Partial Destruction of the Nigro-striatal Dopaminergic System in the Rat

1973 • 363 citations

L-Dopa: Effect on Concentrations of Dopamine, Norepinephrine, and Serotonin in Brains of Mice

1970 • 332 citations

L-Dopa-Induced Release of Cerebral Monoamines

1970 • 327 citations

Decrease of cerebral 5-hydroxytryptamine by 3,4-dihydroxyphenylalanine after inhibition of extracerebral decarboxylase

1968 • 177 citations

Parkinson's Disease: Activity of L-Dopa Decarboxylase in Discrete Brain Regions

1970 • 177 citations

Growth of Pulmonary Alveolar Macrophages in vitro

1973 • 155 citations

Monoamines, noyaux gris centraux et syndrome de Parkinson

1975 • 130 citations

Herabgesetzte Konzentration der Homovanillinsäure im Gehirn von parkinsonkranken Menschen als Ausdruck der Störung des zentralen Dopaminstoffwechsels

1965 • 126 citations

Dopamine-derived tetrahydroisoquinoline alkaloids—Inhibitors of neuroamine metabolism

1973 • 105 citations

L-dopa treatment failure: explanation and correction.

1970 • 91 citations

Monoamines et système nerveux central

1962 • 87 citations

MONOAMINES NOYAUX GRIS CENTRAUX ET SYNDROME DE PARKINSON

1975 • 87 citations

Pharmakologie des Tetrahydropapaverolins und seine Entstehung aus Dopamin

1964 • 76 citations

l-DOPA treatment in Parkinson's disease: Effect on dopamine and related substances in discrete brain regions

1971 • 69 citations

A model for the quantitative study of central dopaminergic and serotoninergic activity

1972 • 63 citations

3-O-Methyldopa, a New Precursor of Dopamine

1971 • 56 citations

Drug Therapy of Parkinsonism

1972 • 54 citations

Erfahrungen mit L-Dopa in der Therapie des Parkinsonismus

1963 • 52 citations

l-DOPA induced effects on motor activity in mice after inhibition of dopamine-?-hydroxylase

1971 • 49 citations

The effect of L-DOPA on brain catecholamines and motility in rats

1971 • 43 citations

Decrease in Liver Aromatic L-Amino-Acid Decarboxylase Produced by Chronic Administration of L-Dopa

1971 • 43 citations

Parkinsonism treated with 3-0-methyldopa

1973 • 36 citations

Distribution and metabolism of <scp>l</scp>‐3‐O‐methyldopa in rats

1970 • 33 citations

On the mode of action of l-dopa in Parkinson's disease

1970 • 32 citations

Evidence for the methylation of apomorphine by catechol-O-methyl-transferase in vivo and in vitro

1973 • 28 citations

TETRAHYDROISOQUINOLINE ALKALOIDS: UPTAKE, STORAGE, AND SECRETION BY THE ADRENAL MEDULLA AND BY ADRENERGIC NERVES*

1973 • 20 citations

Selective antagonism of dopamine by apomorphine

1972 • 16 citations

Effects of levodopa on nondopaminergic brain neurons

1972 • 16 citations

[Substitutive therapy in Parkinson's syndromes. L-dopa plus peripheral decarboxylase inhibitor or 3-0-methyl dopa?].

1971 • 9 citations

BLOOD CATECHOL-O-METHYLTRANSFERASE ACTIVITY IN PARKINSON'S DISEASE

1971 • 8 citations