Venous thrombosis: a multicausal disease

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis

1996 • 3,124 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study

1991 • 1,994 citations

A Population-Based Perspective of the Hospital Incidence and Case-Fatality Rates of Deep Vein Thrombosis and Pulmonary Embolism

1991 • 1,533 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

Deficiency of protein C in congenital thrombotic disease.

1981 • 1,260 citations

World distribution of factor V Leiden

1995 • 1,184 citations

Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis

1995 • 1,117 citations

Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation

1994 • 1,065 citations

Inherited Antithrombin Deficiency Causing Thrombophilia

1965 • 1,040 citations

High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance) [see comments]

1995 • 1,036 citations

Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis

1996 • 1,034 citations

Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE

1994 • 987 citations

A population based perspective of the hospital incidence and case fatality rates of deep vein thrombosis and pulmonary embolism

1992 • 858 citations

Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis

1997 • 850 citations

A prospective study of the incidence of deep‐vein thrombosis within a defined urban population

1992 • 799 citations

A New Theory on the Cancer-inducing Mechanism

1953 • 744 citations

Geographic Distribution of the 20210 G to A Prothrombin Variant

1998 • 707 citations

Haemostasis and Thrombosis.

1982 • 688 citations

High Risk of Cerebral-Vein Thrombosis in Carriers of a Prothrombin-Gene Mutation and in Users of Oral Contraceptives

1998 • 648 citations

Inherited Thrombophilia: Part 1

1996 • 600 citations

Gesammelte Abhandlungen zur wissenschaftlichen Medicin

1862 • 578 citations

Absence of Thrombosis in Subjects with Heterozygous Protein C Deficiency

1987 • 529 citations

Plasma protein S deficiency in familial thrombotic disease

1984 • 516 citations

Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia

1993 • 475 citations

Haemostasis and Thrombosis

1994 • 446 citations

Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families

1994 • 446 citations

Risk Factors for Pregnancy Associated Venous Thromboembolism

1997 • 427 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 411 citations

Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study) [see comments]

1995 • 372 citations

Hyperhomocysteinemia and Venous Thrombosis: A Meta-analysis

1998 • 371 citations

Prevalence of antithrombin deficiency in the healthy population

1994 • 363 citations

Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect

1993 • 354 citations

Epidemiological Study on Factor VII, Factor VIII and Fibrinogen in an Industrial Population: I. Baseline Data on the Relation to Age, Gender, Body-Weight, Smoking, Alcohol, Pill-Using, and Menopause

1985 • 348 citations

INHERITED PROTEIN C DEFICIENCY AND COUMARIN-RESPONSIVE CHRONIC RELAPSING PURPURA FULMINANS IN A NEWBORN INFANT

1983 • 346 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 337 citations

Oral contraceptives and venous thrombosis: different sensitivities to activated protein C in women using second‐ and third‐generation oral contraceptives

1997 • 337 citations

Thrombosis in the Young: Epidemiology and Risk Factors. A Focus on Venous Thrombosis

1997 • 332 citations

Prevalence of Protein C Deficiency in the Healthy Population

1995 • 328 citations

Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S

1995 • 314 citations

VENOUS THROMBOEMBOLIC DISEASE AND ABO BLOOD TYPE

1969 • 311 citations

Case-control study of risk of cerebral sinus thrombosis in oral contraceptive users who are carriers of hereditary prothrombotic conditions

1998 • 287 citations

Thrombosis and Pregnancy in Congenital Deficiencies in AT III, Protein C or Protein S: Study of 78 Women

1990 • 283 citations

EPIDEMIOLOGY OF COAGULATION FACTORS, INHIBITORS AND ACTIVATION MARKERS: THE THIRD GLASGOW MONICA SURVEY I. ILLUSTRATIVE REFERENCE RANGES BY AGE, SEX AND HORMONE USE

1997 • 281 citations

High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.

1994 • 251 citations

Factor V Leiden (FV R506Q) in Families with Inherited Antithrombin Deficiency

1996 • 237 citations

Prevalence of Moderate Hyperhomocysteinemia in Patients with Early-Onset Venous and Arterial Occlusive Disease

1995 • 235 citations

Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptives

1995 • 233 citations

Frequency of Pregnancy-Related Venous Thromboembolism in Anticoagulant Factor-Deficient Women: Implications for Prophylaxis

1996 • 221 citations

Risk factors for venous thrombosis: prevalence, risk, and interaction.

1997 • 221 citations

Co-inheritance of the 20210A Allele of the Prothrombin Gene Increases the Risk of Thrombosis in Subjects with Familial Thrombophilia

1997 • 177 citations

Biological Models and Statistical Interactions: an Example from Multistage Carcinogenesis

1981 • 173 citations

Inherited predisposition to thrombosis

1993 • 166 citations

Clinical Studies and Thrombin Generation in Patients Homozygous or Heterozygous for the G20210A Mutation in the Prothrombin Gene

1998 • 164 citations

Resistance to Activated Protein C and Factor V Leiden as Risk Factors for Venous Thrombosis

1995 • 161 citations

Pregnancy in Women with Congenital Antithrombin III Deficiency: Experience of Treatment with Heparin and Antithrombin

1982 • 161 citations

Arg⁵⁰⁶–Gln mutation in factor V and risk of thrombosis during pregnancy

1996 • 141 citations

Hyperhomocysteinemia and Deep-Vein Thrombosis A Case-Control Study

1996 • 131 citations

Thrombotic risk of women with hereditary antithrombin III-, protein C- and protein S-deficiency taking oral contraceptive medication. The GTH Study Group on Natural Inhibitors.

1994 • 131 citations

Incidence and clinical characteristics of hereditary disorders associated with venous thrombosis

1991 • 127 citations

The spectrum of genetic defects in a panel of 40 Dutch families with symptomatic protein C deficiency type I: heterogeneity and founder effects

1991 • 126 citations

Epidemiological Study on Factor VII, Factor VIII and Fibrinogen in an Industrial Population - II. Baseline Data on the Relation to Blood Pressure, Blood Glucose, Uric Acid, and Lipid Fractions

1985 • 117 citations

Familial Clustering of Factor VIII and von Willebrand Factor Levels

1998 • 111 citations

The Relative Frequency of Hereditary Thrombotic Disorders Among 107 Patients with Thrombophilia in Israel

1989 • 106 citations

Childhood Thrombosis

1995 • 106 citations

Thrombotic Risk of Women with Hereditary Antithrombin III-, Protein C- and Protein S-Deficiency Taking Oral Contraceptive Medication

1994 • 102 citations

The natural history and epidemiology of venous thrombosis

1994 • 97 citations

Pulmonary embolism and deep venous thrombosis during pregnancy or oral contraceptive use: Prevalence of factor V Leiden

1996 • 92 citations

Homozygous protein S deficiency in an infant with purpura fulminans

1990 • 92 citations

Apparent different thrombotic tendency in patients with factor V Leiden and protein C deficiency due to selection of patients

1996 • 86 citations

Analysis of the F8 gene in individuals with high plasma factor VIII: C levels and associated venous thrombosis.

1998 • 74 citations

Markers of Procoagulant Imbalance in Patients with Inherited Thrombophilic Syndromes

1992 • 70 citations

Hemostatic Effects of Oral Contraceptives in Women who Developed Deep-vein Thrombosis while Using Oral Contraceptives

1998 • 67 citations

ORAL CONTRACEPTIVES ENHANCE THE RISK OF CLINICAL MANIFESTATION OF VENOUS THROMBOSIS AT A YOUNG AGE IN FEMALES HOMOZYGOUS FOR FACTOR V LEIDEN

1996 • 66 citations

Thrombotic Risk during Pregnancy and Puerperium in Women with APC-Resistance – Effective Subcutaneous Heparin Prophylaxis in a Pregnant Patient

1995 • 39 citations

[Plasma homocysteine assay in the exploration of thrombosis in young subjects].

1991 • 27 citations

INCIDENCE OF DEFECTIVE T-PA RELEASE IN 158 UNRELATED YOUNG PATIENTS WITH VENOUS THROMBOSIS IN COMPARISON TO PC-, PS-, AT III-, FIBRINOGEN- AND PLASMINOGENDEFICIENCY

1987 • 9 citations