Hsp90 inhibitors deplete key anti‐apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1984 • 6,841 citations

Cisplatin: mode of cytotoxic action and molecular basis of resistance

2003 • 3,150 citations

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

2003 • 1,356 citations

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

1997 • 1,345 citations

Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1

1998 • 1,198 citations

The 90-kDa Molecular Chaperone Family

1998 • 1,008 citations

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

1999 • 979 citations

Principles and Practice of Pediatric Oncology

2002 • 952 citations

Modulation of Akt kinase activity by binding to Hsp90

2000 • 942 citations

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

2000 • 799 citations

In Vivo Function of Hsp90 Is Dependent on ATP Binding and ATP Hydrolysis

1998 • 584 citations

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

1997 • 554 citations

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

2002 • 526 citations

Structural and Functional Analysis of the Middle Segment of Hsp90: Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions

2003 • 453 citations

Advances in enzyme regulation

1988 • 452 citations

The hsp90-based Chaperone System: Involvement in Signal Transduction from a Variety of Hormone and Growth Factor Receptors

1998 • 444 citations

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.

2002 • 427 citations

Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution

2002 • 398 citations

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

1998 • 396 citations

The Hsp90 chaperone complex as a novel target for cancer therapy

2003 • 333 citations

Geldanamycin as a Potential Anti-Cancer Agent: Its Molecular Target and Biochemical Activity

1999 • 297 citations

Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.

2003 • 275 citations

Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway

1996 • 274 citations

Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.

2000 • 260 citations

Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

1998 • 244 citations

Clinical Development of 17-Allylamino, 17-Demethoxygeldanamycin

2003 • 226 citations

A Nucleotide-dependent Molecular Switch Controls ATP Binding at the C-terminal Domain of Hsp90

2002 • 207 citations

The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase

1997 • 202 citations

Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition.

1992 • 177 citations

C-terminal truncation of the retinoblastoma gene product leads to functional inactivation.

1990 • 170 citations

Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001.

2001 • 170 citations

Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells.

2001 • 145 citations

In vitro evidence that hsp90 contains two independent chaperone sites

1997 • 137 citations

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1

2001 • 132 citations

Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.

1996 • 128 citations

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

1997 • 127 citations

Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer.

2001 • 120 citations

Geldanamycin Induces Heat Shock Protein Expression Through Activation of HSF1 in K562 Erythroleukemic Cells

1999 • 104 citations

Reactive Cysteines of the 90-kDa Heat Shock Protein, Hsp90

2000 • 86 citations

Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors.

2003 • 83 citations

Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice.

1998 • 80 citations

A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90

1999 • 78 citations

IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma

2000 • 63 citations

Geldanamycin decreases Raf‐1 and Akt levels and induces apoptosis in neuroblastomas

2002 • 55 citations

Insulin-Like Growth Factor System in Neuroblastoma Tumorigenesis and Apoptosis: Potential Diagnostic and Therapeutic Perspectives

1999 • 45 citations

Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of Cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction.

2003 • 45 citations

Doctor, Does This Mean I'm Going to Starve to Death?

2003 • 37 citations

Neuroblastoma and insulin-like growth factor system

1997 • 34 citations

A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90

1999 • 28 citations