Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

2002 • 6,428 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

2005 • 3,066 citations

Genes that mediate breast cancer metastasis to lung

2005 • 2,834 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Stromal fibroblasts in cancer initiation and progression

2004 • 2,230 citations

Lentivirus-delivered stable gene silencing by RNAi in primary cells

2003 • 1,484 citations

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

2000 • 1,445 citations

Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application

2003 • 974 citations

TUMOR STROMA AND REGULATION OF CANCER DEVELOPMENT

2006 • 972 citations

Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

2006 • 959 citations

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

2008 • 882 citations

MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis

2002 • 879 citations

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

2001 • 854 citations

X chromosomal abnormalities in basal-like human breast cancer

2006 • 838 citations

Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells

2007 • 831 citations

Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells

2005 • 764 citations

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.

1996 • 680 citations

Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size

2005 • 675 citations

PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

2005 • 538 citations

Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins

1995 • 452 citations

Serum protein markers for early detection of ovarian cancer

2005 • 437 citations

Role of osteopontin in tumour progression

2004 • 411 citations

CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity

1997 • 380 citations

Transformation of Different Human Breast Epithelial Cell Types Leads to Distinct Tumor Phenotypes

2007 • 307 citations

Deletion of α4 Integrins from Adult Hematopoietic Cells Reveals Roles in Homeostasis, Regeneration, and Homing

2003 • 303 citations

Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue

2006 • 224 citations

The Functional and Clinical Roles of Osteopontin in Cancer and Metastasis

2001 • 217 citations

Attenuation of diet‐induced atherosclerosis in rabbits with a highly selective 15‐lipoxygenase inhibitor lacking significant antioxidant properties

1997 • 178 citations

Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice.

2002 • 173 citations

Tumor–host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor β1

1999 • 137 citations

The bone marrow constitutes a reservoir of pericyte progenitors

2006 • 131 citations

Osteopontin overexpression in breast cancer: Knowledge gained and possible implications for clinical management

2007 • 131 citations

Deciphering cellular states of innate tumor drug responses.

2006 • 123 citations

The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice

2005 • 107 citations

Characterization of a Population of Cells in the Bone Marrow that Phenotypically Mimics Hematopoietic Stem Cells: Resting Stem Cells or Mystery Population?

1998 • 106 citations

Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis

2005 • 98 citations

Nuclear actin and myosin as control elements in nucleocytoplasmic transport.

1986 • 97 citations

Osteopontin induces multiple changes in gene expression that reflect the six “hallmarks of cancer” in a model of breast cancer progression

2005 • 97 citations

Analysis of tumor‐associated stromal cells using SCID GFP transgenic mice: contribution of local and bone marrow‐derived host cells

2006 • 69 citations

Elevated plasma osteopontin as marker for distant metastases and poor survival in patients with renal cell carcinoma

2007 • 60 citations

Bone marrow and tumour stroma: an intimate relationship

2006 • 40 citations

Human marrow stromal cells activate monocytes to secrete osteopontin, which down-regulates Notch1 gene expression in CD34+ cells

2004 • 39 citations

Mammary tumor development in MMTV-c-myc/MMTV-v-Ha-ras transgenic mice is unaffected by osteopontin deficiency

2000 • 28 citations

Identification of in vitro growth conditions for c-Kit–negative hematopoietic stem cells

2003 • 20 citations