Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

1996 • 1,773 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

1997 • 1,106 citations

The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.

1975 • 856 citations

Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

1972 • 773 citations

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

1991 • 571 citations

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

1995 • 483 citations

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

1991 • 391 citations

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

1997 • 362 citations

A radioimmunoassay for 6-keto- prostaglandin F1α

1978 • 319 citations

Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells

1997 • 317 citations

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.

1975 • 288 citations

Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts.

1995 • 210 citations

Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents.

1985 • 185 citations

PPAR: a mediator of peroxisome proliferator action

1995 • 174 citations

Sulindac sulfide inhibits Ras signaling

1998 • 128 citations

Involvement of tyrosine kinase in the induction of cyclo‐oxygenase and nitric oxide synthase by endotoxin in cultured cells

1994 • 95 citations

Induction of Cyclooxygenase-2 Expression by Peroxisome Proliferators and Non-tetradecanoylphorbol 12,13-Myristate-type Tumor Promoters in Immortalized Mouse Liver Cells

1997 • 90 citations

Lack of covalent modification of prostaglandin synthetase (cyclo-oxygenase) by indomethacin

1977 • 88 citations

The effect of 4-acetamidophenol on prostaglandin synthetase activity in bovine and ram seminal vesicle microsomes

1978 • 58 citations

NSAID-Induced Apoptosis in Rous Sarcoma Virus-Transformed Chicken Embryo Fibroblasts is Dependent on v-src and c-myc and is Inhibited by bcl-2

1997 • 24 citations

The Effects of & Newly Developed Nonsteroidal Anti-inflammatory Drug (M-5011) on Arachidonic Acid Metabolism in Rheumatoid Synovial Fibroblasts

1997 • 10 citations