Studies into the Mechanism Whereby Insulin Activates Pyruvate Dehydrogenase Complex in Adipose Tissue^a

Insulin-Stimulated Hydrolysis of a Novel Glycolipid Generates Modulators of cAMP Phosphodiesterase

1986 • 383 citations

The mammalian pyruvate dehydrogenase complex: Structure and regulation

1983 • 336 citations

Fuel selection in animals

1986 • 313 citations

Regulation of mammalian pyruvate dehydrogenase

1975 • 299 citations

Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria.

1986 • 290 citations

Identification of a novel insulin-sensitive glycophospholipid from H35 hepatoma cells.

1987 • 232 citations

Metabolic Interconversion of Enzymes

1972 • 228 citations

Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galactosamine and D-chiroinositol

1988 • 202 citations

Evidence that insulin activates an intrinsic plasma membrane protease in generating a secondary chemical mediator.

1980 • 175 citations

Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: Evidence for generation of insulin's second messenger in a subcellular system

1980 • 172 citations

Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase

1974 • 157 citations

Insulin Generates an Enzyme Modulator from Hepatic Plasma Membranes: Regulation of Adenosine 3′, 5′-Monophosphate Phosphodiesterase, Pyruvate Dehydrogenase, and Adenylate Cyclase*

1987 • 142 citations

Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase

1977 • 138 citations

Metabolic Interconversion of Enzymes 1973

1974 • 128 citations

Hormonal regulation of pyruvate dehydrogenase

1971 • 127 citations

Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet

1976 • 105 citations

Partial purification from rat adipocyte plasma membranes of a chemical mediator which simulates the action of insulin on pyruvate dehydrogenase.

1981 • 100 citations

Control of pyruvate dehydrogenase interconversion in adipose tissue by insulin

1971 • 99 citations

Pyruvate dehydrogenase kinase/activator in rat heart mitochondria, Assay, effect of starvation, and effect of protein-synthesis inhibitors of starvation

1982 • 91 citations

Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities.

1982 • 85 citations

Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin

1986 • 84 citations

The regulation of fatty acid synthesis in brown adipose tissue by insulin

1982 • 83 citations

Pyruvate dehydrogenase and the hormonal regulation of fat synthesis in mammalian tissues

1978 • 76 citations

Use of toluene-permeabilized mitochondria to study the regulation of adipose tissue pyruvate dehydrogenase in situ. Further evidence that insulin acts through stimulation of pyruvate dehydrogenase phosphate phosphatase

1986 • 74 citations

3 Pyruvate Dehydrogenase

1987 • 69 citations

Incorporation of 32Pi into pyruvate dehydrogenase phosphate in mitochondria from control and insulin-treated adipose tissue

1976 • 63 citations

Studies on the incorporation of [32P]phosphate into pyruvate dehydrogenase in intact rat fat-cells. Effects of insulin

1980 • 61 citations

The mechanisms of insulin action

1987 • 60 citations

Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat epididymal adipose tissue. Evidence against a role for Ca2+ in the activation of pyruvate dehydrogenase by insulin

1984 • 60 citations

Stimulation of pyruvate dehydrogenase phosphatase activity by polyamines

1984 • 59 citations

Localisation of the insulin-sensitive phosphatidylinositol glycan at the outer surface of the cell membrane

1988 • 52 citations

Matrix magnesium and the permeability of heart mitochondria to potassium ion.

1986 • 49 citations

The roles of intrinsic kinase and of kinase/activator protein in the enhanced phosphorylation of pyruvate dehydrogenase complex in starvation

1984 • 45 citations

The insulinomimetic effects of the polar head group of an insulin-sensitive glycophospholipid on pyruvate dehydrogenase in both subcellular and whole cell assays

1988 • 36 citations

Persistence of the effect of insulin on pyruvate dehydrogenase activity in rat white and brown adipose tissue during the preparation and subsequent incubation of mitochondria

1984 • 36 citations

ATP-Mn2+ stimulates the generation of a putative mediator of insulin action.

1987 • 35 citations

Insulin reverses effects of starvation on the activity of pyruvate dehydrogenase kinase in cultured hepatocytes

1987 • 31 citations

Absent pyruvate inhibition of pyruvate dehydrogenase kinase in lactating rat mammary gland following various treatments

1979 • 25 citations

Parallel increases in rates of fatty acid synthesis and in pyruvate dehydrogenase activity in isolated rat hepatocytes incubated with insulin

1982 • 24 citations

Insulin activates pyruvate dehydrogenase by lowering the mitochondrial acetyl‐CoA/CoA ratio as evidenced by digitonin fraction of isolated fat cells

1978 • 23 citations

Regulation by Insulin and Free Fatty Acids of Pyruvate Dehydrogenase Activity in Perfused Rat Liver

1977 • 19 citations

Regulation of Fatty Acid Synthesis and Esterification in Rat Epididymal Adipose Tissue: Effects of Insulin, Palmitate and 2-Bromopalmitate

1977 • 15 citations

On the Mechanism of Insulin Action on Pyruvate Dehydrogenase Interconversion in Adipose Tissue

1974 • 5 citations