DNA Methylation: An Introduction to the Biology and the Disease-Associated Changes of a Promising Biomarker

Chromatin Modifications and Their Function

2007 • 10,144 citations

DNA methylation patterns and epigenetic memory

2002 • 6,778 citations

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

The Epigenomics of Cancer

2007 • 4,239 citations

Epigenetic differences arise during the lifetime of monozygotic twins

2005 • 3,451 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Epigenetic Reprogramming in Mammalian Development

2001 • 2,978 citations

DNA methylation and human disease

2005 • 2,681 citations

Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility

2005 • 2,448 citations

Genomic DNA methylation: the mark and its mediators

2006 • 2,428 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Genomic imprinting: parental influence on the genome

2001 • 2,253 citations

Linking DNA methylation and histone modification: patterns and paradigms

2009 • 2,133 citations

Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation

2003 • 1,970 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

The power and the promise of DNA methylation markers

2003 • 1,544 citations

DNA methylation in cancer: too much, but also too little

2002 • 1,509 citations

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

2002 • 1,485 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Epigenetic therapy of cancer: past, present and future

2006 • 1,271 citations

Two genetic hits (more or less) to cancer

2001 • 1,108 citations

CpG island methylator phenotype in cancer

2004 • 1,052 citations

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status

2002 • 918 citations

RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse

2006 • 897 citations

Cyclical DNA methylation of a transcriptionally active promoter

2008 • 874 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

CpG islands – ‘A rough guide’

2009 • 831 citations

Worms gang up on bacteria

2002 • 828 citations

Circulating nucleic acids (CNAs) and cancer—A survey

2006 • 821 citations

Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

2007 • 795 citations

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation

2007 • 744 citations

Epigenetics and aging: the targets and the marks

2007 • 652 citations

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

2008 • 647 citations

Accelerated age-related CpG island methylation in ulcerative colitis.

2001 • 624 citations

A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci

2008 • 615 citations

Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene

2007 • 598 citations

The genetics and genomics of cancer

2003 • 570 citations

W. H. Fox Talbot and the history of photography

1977 • 564 citations

Transgenerational Epigenetic Effects

2008 • 560 citations

Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease

2003 • 541 citations

The Colorful History of Active DNA Demethylation

2008 • 510 citations

Dosage compensation in mammals: fine-tuning the expression of the X chromosome

2006 • 502 citations

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2

2006 • 502 citations

Detection and interpretation of altered methylation patterns in cancer cells

2005 • 482 citations

Activation-induced Cytidine Deaminase Deaminates 5-Methylcytosine in DNA and Is Expressed in Pluripotent Tissues

2004 • 474 citations

Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder

2006 • 452 citations

Structure, function and evolution of CpG island promoters

2003 • 425 citations

Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band

2006 • 398 citations

Cancer epigenetics

2005 • 393 citations

Computational and experimental identification of novel human imprinted genes

2007 • 388 citations

Roadmap for Developing and Validating Therapeutically Relevant Genomic Classifiers

2005 • 374 citations

Mammalian DNA Methyltransferases: A Structural Perspective

2008 • 373 citations

Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters

2007 • 365 citations

Reduced MeCP2 Expression is Frequent in Autism Frontal Cortex and Correlates with Aberrant MECP2 Promoter Methylation

2006 • 330 citations

A Family of Human Zinc Finger Proteins That Bind Methylated DNA and Repress Transcription

2005 • 325 citations

Histone modifications: signalling receptors and potential elements of a heritable epigenetic code

2006 • 314 citations

The impact of metabolism on DNA methylation

2005 • 308 citations

Chromatin remodeling, histone modifications, and DNA methylation—how does it all fit together?

2002 • 303 citations

Epigenetic reprogramming and imprinting in origins of disease

2007 • 260 citations

Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: Association with genomic DNA hypomethylation and influence on gene expression

2000 • 258 citations

Regional copy number–independent deregulation of transcription in cancer

2006 • 245 citations

Epigenetic germline inheritance

2004 • 241 citations

Presence of tumor DNA in plasma of breast cancer patients: clinicopathological correlations.

1999 • 238 citations

p15INK4BCpG Island Methylation in Primary Acute Leukemia Is Heterogeneous and Suggests Density as a Critical Factor for Transcriptional Silencing

1999 • 236 citations

Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men

2009 • 233 citations

Environmental and nutritional effects on the epigenetic regulation of genes

2006 • 223 citations

CpG Island Methylation in Human Lymphocytes Is Highly Correlated with DNA Sequence, Repeats, and Predicted DNA Structure

2006 • 220 citations

X inactivation and the complexities of silencing a sex chromosome

2009 • 208 citations

Assisted Reproductive Technology affects developmental kinetics, H19 Imprinting Control Region methylation and H19gene expression in individual mouse embryos

2007 • 204 citations

Epigenetic reprogramming in embryonic and foetal development upon somatic cell nuclear transfer cloning

2008 • 203 citations

How imprinting centres work

2006 • 200 citations

Epigenetic mechanisms in the context of complex diseases

2007 • 171 citations

Epigenetic programming of the germ line: effects of endocrine disruptors on the development of transgenerational disease

2008 • 164 citations

Epigenetic dysregulation in cognitive disorders

2009 • 160 citations

Asthma and pregnancy: emerging evidence of epigenetic interactions in utero

2009 • 146 citations

Histone modifications dictate specific biological readouts

2009 • 127 citations

DNA motifs associated with aberrant CpG island methylation

2006 • 111 citations

DNA methylation reprogramming in the germ line

2008 • 102 citations

Report on the IASO Stock Conference 2006: early and lifelong environmental epigenomic programming of metabolic syndrome, obesity and type II diabetes

2007 • 97 citations

Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes

2009 • 94 citations

The endothelin receptor B (EDNRB) promoter displays heterogeneous, site specific methylation patterns in normal and tumor cells

2001 • 93 citations

The folding and unfolding of eukaryotic chromatin

2009 • 91 citations

DNA Methylation and Systemic Lupus Erythematosus

2007 • 86 citations

Inherited variation at the epigenetic level: paramutation from the plant to the mouse

2008 • 68 citations

Silver-Russell and Beckwith-Wiedemann Syndromes: Opposite (Epi)Mutations in 11p15 Result in Opposite Clinical Pictures

2009 • 58 citations

Regulation of imprinted DNA methylation

2006 • 55 citations

Dynamic Regulation of DNA Methylation During Mammalian Development

2009 • 44 citations

Epigenetics and assisted reproduction

2009 • 43 citations

Genetic Imprinting: The Paradigm of Prader-Willi and Angelman Syndromes

2009 • 40 citations

Epigenetics in Reproductive Medicine

2007 • 40 citations

Hypothesis: Dysregulation of methylation of brain‐expressed genes on the X chromosome and autism spectrum disorders

2008 • 27 citations

DNA methylation immediately adjacent to active histone marking does not silence transcription

2007 • 27 citations

DNA methylation research trends

2007 • 3 citations