Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: Association with genomic DNA hypomethylation and influence on gene expression

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries.

1996 • 3,063 citations

Human L1 Retrotransposon Encodes a Conserved Endonuclease Required for Retrotransposition

1996 • 1,093 citations

High Frequency Retrotransposition in Cultured Mammalian Cells

1996 • 989 citations

Expression of galectin-3 modulates T-cell growth and apoptosis.

1996 • 771 citations

Reverse Transcriptase Encoded by a Human Transposable Element

1991 • 748 citations

Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.

1992 • 551 citations

The impact of L1 retrotransposons on the human genome

1998 • 515 citations

Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis

1997 • 477 citations

Many human L1 elements are capable of retrotransposition

1997 • 436 citations

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

1997 • 424 citations

A Human Endogenous Retroviral Superantigen as Candidate Autoimmune Gene in Type I Diabetes

1997 • 404 citations

Ancestral, Mammalian-wide Subfamilies of LINE-1 Repetitive Sequences

1995 • 382 citations

Positional cloning of the gene for X-linked retinitis pigmentosa 2

1998 • 371 citations

Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase

1997 • 332 citations

Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma

1988 • 320 citations

Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.

1997 • 288 citations

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

1993 • 287 citations

Induction of Collagenase-3 (MMP-13) Expression in Human Skin Fibroblasts by Three-dimensional Collagen Is Mediated by p38 Mitogen-activated Protein Kinase

1999 • 282 citations

Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction?

1993 • 272 citations

DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas

1999 • 250 citations

Targeting of Human Retrotransposon Integration Is Directed by the Specificity of the L1 Endonuclease for Regions of Unusual DNA Structure

1998 • 236 citations

Mobile elements and disease

1998 • 231 citations

Regulation of Interleukin-1β-induced Interleukin-6 Gene Expression in Human Fibroblast-like Synoviocytes by p38 Mitogen-activated Protein Kinase

1998 • 228 citations

A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion

1994 • 226 citations

Identification of critical CpG sites for repression of L1 transcription by DNA methylation

1997 • 198 citations

Galectin-3 Stimulates Cell Proliferation

1998 • 188 citations

Sequence-specific single-strand RNA binding protein encoded by the human LINE-1 retrotransposon

1997 • 187 citations

The role of p38 mitogen‐activated protein kinase in IL‐6 and IL‐8 production from the TNF‐α‐ or IL‐1β‐stimulated rheumatoid synovial fibroblasts

1999 • 180 citations

Expression of a cytoplasmic LINE-1 transcript is regulated in a human teratocarcinoma cell line.

1985 • 164 citations

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates

1994 • 145 citations

Studies on p40, the leucine zipper motif-containing protein encoded by the first open reading frame of an active human LINE-1 transposable element.

1992 • 115 citations

LINE-1 Elements at the Sites of Molecular Rearrangements in Alport Syndrome–Diffuse Leiomyomatosis

1999 • 111 citations

Role of p38 mitogen-activated protein kinase in HIV type 1 production in vitro

1998 • 100 citations

Reverse transcriptase activity from human embryonal carcinoma cells NTera2D1.

1990 • 93 citations

DNA hypomethylation in inflammatory arthritis: Reversal with methotrexate

1996 • 91 citations

Direct evidence for the expression of multiple endogenous retroviruses in the synovial compartment in rheumatoid arthritis

1997 • 81 citations

Use of a differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes

1998 • 74 citations

Identification of Stathmin as a Novel Substrate for p38 Delta

1998 • 72 citations

Expression of LINE-1 retrotransposons in human breast cancer

1994 • 72 citations

Characterization of a nondeleterious L1 insertion in an intron of the human factor VIII gene and further evidence of open reading frames in functional L1 elements

1989 • 69 citations

Comparative expression of the LINE-1 p40 protein in human breast carcinomas and normal breast tissues.

1996 • 67 citations

Human endogenous retrovirus expression and reverse transcriptase activity in the T47D mammary carcinoma cell line

1996 • 66 citations

Hepatocyte growth factor. A cytokine mediating endothelial migration in inflammatory arthritis

1996 • 66 citations

Analysis of the Promoter from an Expanding Mouse Retrotransposon Subfamily

1999 • 65 citations

Detection of human retrovirus 5 in patients with arthritis and systemic lupus erythematosus

1999 • 58 citations

VIRUS-LIKE PARTICLES IN SYNOVIAL FLUIDS FROM PATIENTS WITH RHEUMATOID ARTHRITIS

1993 • 58 citations

The use of primers from highly conserved pol regions to identify uncharacterized retroviruses by the polymerase chain reaction

1990 • 57 citations

RNA polymerase III dependence of the human L1 promoter and possible participation of the RNA polymerase II factor YY1 in the RNA polymerase III transcription system

1995 • 51 citations

Molecular Investigations Implicate Human Endogenous Retroviruses as Mediators of Anti-Retroviral Antibodies in Autoimmune Rheumatic Disease

1999 • 50 citations

An endogenous retroviral long terminal repeat at the HLA-DQB1 gene locus confers susceptibility to rheumatoid arthritis

1999 • 46 citations

Galectin-3 and L1 retrotransposons in human breast carcinomas

1998 • 43 citations

LINE-I element insertion at the t(11;22) translocation breakpoint of a desmoplastic small round cell tumor

1997 • 43 citations

Acute Infection of Sindbis Virus Induces Phosphorylation and Intracellular Translocation of Small Heat Shock Protein HSP27 and Activation of p38 MAP Kinase Signaling Pathway

1998 • 43 citations

It's Prime Time for Reverse Transcriptase

1997 • 39 citations

Characterization of Human Endogenous Retrovirus Type K Virus-like Particles Generated from Recombinant Baculoviruses

1997 • 34 citations

Identification of S71-Related Human Endogenous Retroviral Sequences with Full-Length pol Genes

1995 • 28 citations

Absence of Lentiviral and Human T Cell Leukemia Viral Sequences in Patients with Rheumatoid Arthritis

1994 • 28 citations

Retrovirus-associated rheumatic syndromes

1998 • 28 citations

Mapping of Retrotransposon Sequences in the Unstable Region Surrounding the Spinal Muscular Atrophy Locus in 5q13

1995 • 25 citations

Analysis of Three Deletion Breakpoints in Xp21.1 and the Further Localization of RP3

1996 • 22 citations

Human Endogenous Retrovirus HC2 Is a New Member of the S71 Retroviral Subgroup with a Full-LengthpolGene

1996 • 20 citations

Repetitive nucleotide sequence insertions into a novel calmodulin-related gene and its processed pseudogene

1988 • 19 citations

Retroviral Sequences in Rheumatoid Arthritis Synovium

1998 • 10 citations

The interleukin-6 gene locus seems to be a preferred target site for retrotransposon integration

1991 • 9 citations

Endogenous retroviruses in the human genome—A point of view

1995 • 8 citations

Cloning and characterization of the endogenous retroviral-tRNAGlu multigene family from human genomes of different racial backgrounds

1995 • 6 citations

Laminin-binding proteins in EJ-ras-transformed fibroblasts.

1996 • 5 citations

Impact of human endogenous retroviral elements on cellular genes: strategy for isolation of LTR-driven chimeric transcripts

1999 • 4 citations