Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters

Gene Ontology: tool for the unification of biology

2000 • 38,297 citations

DNA methylation patterns and epigenetic memory

2002 • 6,778 citations

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

2003 • 6,017 citations

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Epigenetic Reprogramming in Mammalian Development

2001 • 2,978 citations

More powerful procedures for multiple significance testing

1990 • 2,572 citations

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

2007 • 2,094 citations

The Role of DNA Methylation in Mammalian Epigenetics

2001 • 1,956 citations

Chromatin modification and epigenetic reprogramming in mammalian development

2002 • 1,870 citations

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 • 1,865 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

DNA methylation in cancer: too much, but also too little

2002 • 1,509 citations

DNA methylation profiling of human chromosomes 6, 20 and 22

2006 • 1,308 citations

GOstat: find statistically overrepresented Gene Ontologies within a group of genes

2004 • 1,232 citations

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

2002 • 1,231 citations

Combining evidence using p-values: application to sequence homology searches.

1998 • 1,188 citations

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

1979 • 1,101 citations

A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements

2004 • 998 citations

Unsupervised learning of multiple motifs in biopolymers using expectation maximization

1995 • 680 citations

The DNA methylation paradox

1999 • 642 citations

DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter

1999 • 589 citations

Sensitive and quantitative universal Pyrosequencing™ methylation analysis of CpG sites

2003 • 494 citations

Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.

1999 • 475 citations

CpG methylation is maintained in human cancer cells lacking DNMT1

2000 • 453 citations

Role for DNA methylation in the control of cell type–specific maspin expression

2002 • 440 citations

Cytosine methylation and mammalian development

1999 • 384 citations

DNA methylation and genomic imprinting

1994 • 349 citations

Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression

2005 • 332 citations

Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.

1994 • 292 citations

Predicting aberrant CpG island methylation

2003 • 283 citations

Non-methylated CpG-rich islands at the human alpha-globin locus: implications for evolution of the alpha-globin pseudogene.

1987 • 201 citations

A Comprehensive Analysis of Allelic Methylation Status of CpG Islands on Human Chromosome 21q

2004 • 173 citations

Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3

2005 • 160 citations

Roles of Cell Division and Gene Transcription in the Methylation of CpG Islands

1999 • 134 citations

Developmental differences in methylation of human Alu repeats.

1993 • 129 citations

Optimizing Annealing Temperature Overcomes Bias in Bisulfite PCR Methylation Analysis

2007 • 126 citations

Sohlh2 is a germ cell-specific bHLH transcription factor

2006 • 114 citations

DNA motifs associated with aberrant CpG island methylation

2006 • 111 citations

Alu repeated DNAs are differentially methylated in primate germ cells

1994 • 107 citations

Tandem B1 Elements Located in a Mouse Methylation Center Provide a Target for de Novo DNA Methylation

1999 • 91 citations

Analysis of tissue-specific differentially methylated regions (TDMs) in humans

2007 • 86 citations