Report on the IASO Stock Conference 2006: early and lifelong environmental epigenomic programming of metabolic syndrome, obesity and type II diabetes

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

DNA methylation patterns and epigenetic memory

2002 • 6,778 citations

Epigenetic programming by maternal behavior

2004 • 5,974 citations

Epigenetics in human disease and prospects for epigenetic therapy

2004 • 3,142 citations

CANALIZATION OF DEVELOPMENT AND THE INHERITANCE OF ACQUIRED CHARACTERS

1942 • 3,059 citations

Epigenetic Reprogramming in Mammalian Development

2001 • 2,978 citations

Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility

2005 • 2,448 citations

Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation

2003 • 1,970 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

Kaplan & Sadock's Comprehensive Textbook of Psychiatry

2000 • 1,469 citations

Epigenetic inheritance at the agouti locus in the mouse

1999 • 1,414 citations

Epigenetic reprogramming in mammals

2005 • 1,326 citations

Role of transposable elements in heterochromatin and epigenetic control

2004 • 1,198 citations

Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding

2004 • 1,188 citations

Epigenetic reprogramming in mouse primordial germ cells

2002 • 1,159 citations

The Human Obesity Gene Map: The 2005 Update

2006 • 1,148 citations

Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins

2004 • 1,049 citations

Kaplan and Sadock's Comprehensive Text Book of Psychiatry

2005 • 1,017 citations

Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.

1998 • 964 citations

Maternal Genistein Alters Coat Color and Protects A ^vy Mouse Offspring from Obesity by Modifying the Fetal Epigenome

2006 • 915 citations

Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life

2005 • 904 citations

Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period

2002 • 862 citations

Maternal epigenetics and methyl supplements affectagoutigene expression inA^vy/amice

1998 • 851 citations

Circadian Regulator CLOCK Is a Histone Acetyltransferase

2006 • 848 citations

Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension

2000 • 810 citations

Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases

2003 • 788 citations

Maternal Methyl Supplements in Mice Affect Epigenetic Variation and DNA Methylation of Offspring

2002 • 782 citations

Early origins of cardiovascular disease: is there a unifying hypothesis?

2004 • 775 citations

Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood

2006 • 769 citations

The key to development: interpreting the histone code?

2005 • 729 citations

Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring

2006 • 657 citations

Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse

2003 • 631 citations

Accelerated age-related CpG island methylation in ulcerative colitis.

2001 • 624 citations

Transgenerational inheritance of epigenetic states at the murine Axin ^Fu allele occurs after maternal and paternal transmission

2003 • 621 citations

Neonatal Leptin Treatment Reverses Developmental Programming

2005 • 617 citations

Potential mechanisms of metabolic imprinting that lead to chronic disease

1999 • 592 citations

Culture of Preimplantation Mouse Embryos Affects Fetal Development and the Expression of Imprinted Genes1

2001 • 564 citations

The role of RNA interference in heterochromatic silencing

2004 • 563 citations

Catch-up growth and obesity in male mice

2004 • 547 citations

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

2003 • 534 citations

The Changing Concept of Epigenetics

2002 • 517 citations

MGMT Promoter Methylation and Field Defect in Sporadic Colorectal Cancer

2005 • 485 citations

Maternal methyl supplements increase offspring DNA methylation at Axin fused

2006 • 479 citations

Homocysteine and folate metabolism in depression

2005 • 440 citations

Errors in development of fetuses and placentas from in vitro-produced bovine embryos

2005 • 431 citations

Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia

2003 • 428 citations

The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk

2004 • 420 citations

Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells.

2001 • 417 citations

Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats

2004 • 411 citations

A low maternal protein diet during pregnancy and lactation has sex‐ and window of exposure‐specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat

2005 • 399 citations

Role of premature leptin surge in obesity resulting from intrauterine undernutrition

2005 • 389 citations

Age Related Changes in 5‐methylcytosine Content in Human Peripheral Leukocytes and Placentas: an HPLC‐based Study

2004 • 388 citations

Critical Role of Histone Methylation in Tumor Suppressor Gene Silencing in Colorectal Cancer

2002 • 352 citations

Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition

2003 • 347 citations

Retrotransposons as epigenetic mediators of phenotypic variation in mammals

2001 • 339 citations

Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression

2005 • 332 citations

Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus

2006 • 331 citations

Sex differences in transgenerational alterations of growth and metabolism in progeny (F₂) of female offspring (F₁) of rats fed a low protein diet during pregnancy and lactation

2005 • 328 citations

Metabolic Interactions of Alcohol and Folate

2002 • 308 citations

Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy

2004 • 307 citations

Unbalanced Placental Expression of Imprinted Genes in Human Intrauterine Growth Restriction

2005 • 297 citations

Predicting aberrant CpG island methylation

2003 • 283 citations

Assessing the Effects of High Methionine Intake on DNA Methylation

2006 • 278 citations

Nutritional Epigenomics of Metabolic Syndrome

2005 • 276 citations

On the epigenetic regulation of the human reelin promoter

2002 • 266 citations

The imprinted signaling protein XLαs is required for postnatal adaptation to feeding

2004 • 262 citations

Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice

2005 • 258 citations

Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes

2006 • 250 citations

Dnmt1Overexpression Causes Genomic Hypermethylation, Loss of Imprinting, and Embryonic Lethality

2002 • 250 citations

Dynamic Reprogramming of DNA Methylation at an Epigenetically Sensitive Allele in Mice

2006 • 244 citations

Intra- and Interindividual Epigenetic Variation in Human Germ Cells

2006 • 232 citations

Increased maternal nutrition alters development of the appetite‐regulating network in the brain

2006 • 228 citations

Role of S-adenosyl-l-methionine in the treatment of depression: a review of the evidence,,,

2002 • 226 citations

Environmental and nutritional effects on the epigenetic regulation of genes

2006 • 223 citations

Maternal diabetes during pregnancy: Consequences for the offspring

1990 • 220 citations

Coadaptation in mother and infant regulated by a paternally expressed imprinted gene

2004 • 218 citations

Methylomics in psychiatry: Modulation of gene–environment interactions may be through DNA methylation

2003 • 215 citations

G<scp>ENETIC</scp>E<scp>FFECTS OF</scp>M<scp>ETHYLATION</scp>D<scp>IETS</scp>

2002 • 212 citations

Animal evidence for the transgenerational development of diabetes mellitus

2005 • 209 citations

Role of S-adenosyl-l-methionine in the treatment of depression: a review of the evidence,,,

2002 • 205 citations

The Importance of Catch‐up Growth after Early Malnutrition for the Programming of Obesity in Male Rat

2006 • 195 citations

Maternal programming of defensive responses through sustained effects on gene expression

2006 • 192 citations

Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster

2006 • 186 citations

Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats

2003 • 180 citations

Epigenomics and epigenetic therapy of cancer

2002 • 172 citations

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism

2005 • 171 citations

Towards the Human Cancer Epigenome: A First Draft of Histone Modifications

2005 • 170 citations

Epigenetic changes in estrogen receptor β gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence

2006 • 168 citations

The marks, mechanisms and memory of epigenetic states in mammals

2001 • 167 citations

Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3

2005 • 160 citations

Paternal versus maternal transmission of a stimulatory G-protein α subunit knockout produces opposite effects on energy metabolism

2000 • 153 citations

Release of Methyl CpG Binding Proteins and Histone Deacetylase 1 from the Estrogen Receptor α (ER) Promoter upon Reactivation in ER-Negative Human Breast Cancer Cells

2005 • 151 citations

Health Effects of Phytoestrogens

2005 • 148 citations

Preweaning food intake influences the adiposity of young adult baboons.

1986 • 146 citations

Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation

2004 • 146 citations

Altercation of Generations: Genetic Conflicts of Pregnancy

1996 • 144 citations

Metabolic Programming: Causes and Consequences

2002 • 141 citations

Imprinted Nesp55 Influences Behavioral Reactivity to Novel Environments

2005 • 138 citations

Hsp90 and environmental impacts on epigenetic states: a model for the trans-generational effects of diethylstibesterol on uterine development and cancer

2005 • 137 citations

Epigenetics and phenotypic variation in mammals

2006 • 130 citations

The fetal origins of diseases of old age.

1992 • 124 citations

Taurine Supplementation of a Low Protein Diet Fed to Rat Dams Normalizes the Vascularization of the Fetal Endocrine Pancreas

2003 • 123 citations

Methylation of the estrogen receptor-α gene promoter is selectively increased in proliferating human aortic smooth muscle cells

2000 • 119 citations

Twelve generations of marginal protein deficiency

1975 • 113 citations

The daily rhythms of genes, cells and organs

2005 • 112 citations

Timing of nutrient restriction and programming of fetal adipose tissue development

2004 • 112 citations

Epigenetic and Genomic Imprinting Analysis in Nuclear Transfer Derived Bos gaurus/Bos taurus Hybrid Fetuses1

2004 • 111 citations

Programming of obesity and cardiovascular disease

2004 • 110 citations

Inheritance of Diabetes Mellitus as Consequence of Gestational Hyperglycemia in Rats

1990 • 102 citations

Cross-Fostering to Diabetic Rat Dams Affects Early Development of Mediobasal Hypothalamic Nuclei Regulating Food Intake, Body Weight, and Metabolism

2004 • 102 citations

The marks, mechanisms and memory of epigenetic states in mammals

2001 • 102 citations

Inhibition of Histone Deacetylase Activity by Valproic Acid Blocks Adipogenesis

2004 • 101 citations

The Alternative Stimulatory G Protein α-Subunit XLαs Is a Critical Regulator of Energy and Glucose Metabolism and Sympathetic Nerve Activity in Adult Mice

2006 • 96 citations

Betel nut (Areca catechu) consumption and the induction of glucose intolerance in adult CD1 mice and in their F1 and F2 offspring

1994 • 93 citations

Maternal hyperinsulinemia predisposes rat fetuses for hyperinsulinemia, and adult-onset obesity and maternal mild food restriction reverses this phenotype

2005 • 85 citations

DNA Methyltransferase 1 Knockdown Activates a Replication Stress Checkpoint

2006 • 84 citations

Epigenetic and gene expression changes related to transgenerational carcinogenesis

2004 • 82 citations

Nutritional Origins of Insulin Resistance: A Rat Model for Diabetes-Prone Human Populations

2000 • 81 citations

Seminiferous Cord Formation and Germ‐Cell Programming: Epigenetic Transgenerational Actions of Endocrine Disruptors

2005 • 80 citations

Resistance to high-fat diet in the female progeny of obese mice fed a control diet during the periconceptual, gestation, and lactation periods

2006 • 79 citations

Reproductive epigenetics

2004 • 79 citations

Intra-uterine Transmission of Disease

2003 • 79 citations

Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation

2005 • 77 citations

Interindividual variability and parent of origin DNA methylation differences at specific human Alu elements

2005 • 77 citations

Transgenerational effects of drug and hormonal treatments in mammals: a review of observations and ideas

1988 • 74 citations

Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA

1989 • 74 citations

Recognition of Rh Genotypes in Man

1943 • 67 citations

Imprinting and Transgenerational Modulation of Gene Expression; Human Growth as a Model

1996 • 65 citations

Regional expression of brain derived neurotrophic factor (BDNF) is correlated with dynamic patterns of promoter methylation in the developing mouse forebrain

2005 • 63 citations

Type�2 diabetes mellitus ? genes or intrauterine environment? An embryo transfer paradigm in rats

2004 • 62 citations

The silence of the ribosomal RNA genes

2005 • 61 citations

Impact of Paternal Exposure to Chemotherapy on Offspring in the Rat

2005 • 61 citations

Programming of Islet Functions in the Progeny of Hyperinsulinemic/Obese Rats

2003 • 61 citations

A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder

2002 • 56 citations

Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display

2004 • 54 citations

Environmental effects on genomic imprinting in mammals

2001 • 48 citations

A methylation profile of in vitro immortalized human cell lines

2005 • 42 citations

Chemical carcinogen-induced decreases in genomic 5-methyldeoxycytidine content of normal human bronchial epithelial cells.

1987 • 40 citations

Influence of exercise-induced maternal stress on fetal outcome in Wistar rats: Inter-generational effects

1995 • 40 citations

Intergenerational Effect of an Adverse Intrauterine Environment on Perturbation of Glucose Metabolism

2001 • 38 citations

Strategies for dissecting epigenetic mechanisms in the mouse

2005 • 38 citations

Épigénomique nutritionnelle du syndrome métabolique

2005 • 38 citations

Cloning and transgenesis in mammals: Implications for xenotransplantation

2004 • 33 citations

Epigenetic cancer therapies: DNA methyltransferase inhibitors

2002 • 33 citations

Insulin-like growth factor II and its receptors in atherosclerosis and in conditions predisposing to atherosclerosis.

2003 • 26 citations

Insulin-like growth factor II and its receptors in atherosclerosis and in conditions predisposing to atherosclerosis

2003 • 25 citations

Epigenetic studies of genomic retroelements in major psychosis

2003 • 21 citations

L'empreinte parentale : de la guerre des sexes à la solidarité entre générations.

2000 • 12 citations

Persistence of impaired insulin secretion in infant rhesus monkeys that had been hyperinsulinemic in utero.

1992 • 9 citations

Persistence of impaired insulin secretion in infant rhesus monkeys that had been hyperinsulinemic in utero

1992 • 7 citations