Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

Identification of a Nuclear Receptor for Bile Acids

1999 • 2,537 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 • 2,142 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1999 • 1,965 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

1999 • 1,528 citations

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.

1986 • 1,282 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

1996 • 992 citations

The nuclear receptor ligand-binding domain: structure and function

1998 • 829 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

1994 • 460 citations

Hyperexpression of mitogen-activated protein kinase in human breast cancer.

1997 • 454 citations

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

1993 • 451 citations

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

1991 • 446 citations

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

1989 • 428 citations

Estrogen Control of Progesterone Receptor in Human Breast Cancer: Role of Estradiol and Antiestrogen*

1978 • 407 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.

1994 • 354 citations

Cross-Talk between Peptide Growth Factor and Estrogen Receptor Signaling Pathways

1998 • 334 citations

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.

1994 • 324 citations

A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

1998 • 311 citations

Identification of two transactlvation domains in the mouse oestrogen receptor

1989 • 303 citations

Estrogen receptor alpha in human breast cancer: occurrence and significance.

2000 • 302 citations

Orphan nuclear receptors—new ligands and new possibilities: Figure 1.

1998 • 301 citations

Activation of Estrogen Receptor α by S118 Phosphorylation Involves a Ligand-Dependent Interaction with TFIIH and Participation of CDK7

2000 • 286 citations

Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).

1994 • 254 citations

Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer

2001 • 250 citations

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

1995 • 230 citations

Estradiol-induced Phosphorylation of Serine 118 in the Estrogen Receptor Is Independent of p42/p44 Mitogen-activated Protein Kinase

1998 • 212 citations

Potentiation of Human Estrogen Receptor α Transcriptional Activation through Phosphorylation of Serines 104 and 106 by the Cyclin A-CDK2 Complex

1999 • 200 citations

The Transcriptional Elongation Inhibitor 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole Inhibits Transcription Factor IIH-associated Protein Kinase

1995 • 178 citations

Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor.

1994 • 165 citations

p300 Mediates Functional Synergism between AF-1 and AF-2 of Estrogen Receptor α and β by Interacting Directly with the N-terminal A/B Domains

2000 • 154 citations

Oestrogen receptor: a stable phenotype in breast cancer

1996 • 145 citations

Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo.

1995 • 119 citations

Modulating nuclear receptor function: may the phos be with you

1999 • 119 citations

Phosphorylation of the human estrogen receptor by mitogen-activated protein kinase and casein kinase II: Consequence on DNA binding

1995 • 109 citations

A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor).

1993 • 103 citations

Production and Characterization of Monoclonal Antibodies Recognising Defined Regions of the Human Oestrogen Receptor

1993 • 66 citations

Untitled

2000 • 33 citations

How do breast cancers become hormone resistant?

1994 • 32 citations

A Conserved C-Terminal Sequence That Is Deleted in v-ErbA is Essential for the Biological Activities of c-ErbA (the Thyroid Hormone Receptor)

1993 • 25 citations