Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. 1956.

1990 • 1,075 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 682 citations

Binding proteins for the insulin-like growth factors: Structure, regulation and function

1989 • 565 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Synthesis and Secretion of Insulin-like Growth Factor II by a Leiomyosarcoma with Associated Hypoglycemia

1988 • 346 citations

Developmental regulation of the rat insulin-like growth factor I receptor gene.

1989 • 338 citations

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 • 322 citations

Cellular Pattern of Insulin-Like Growth Factor-I (IGF-I) and Type I IGF Receptor Gene Expression in Early Organogenesis: Comparison with IGF-II Gene Expression

1990 • 320 citations

Molecular Cloning of Rat Insulin-Like Growth Factor I Complementary Deoxyribonucleic Acids: Differential Messenger Ribonucleic Acid Processing and Regulation by Growth Hormone in Extrahepatic Tissues

1987 • 275 citations

Nucleotide Sequence and Expression of a cDNA Clone Encoding a Fetal Rat Binding Protein for Insulin-like Growth Factors

1989 • 263 citations

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

1988 • 262 citations

Insulin-Like Growth Factor-ll (IGF-II): A Potential Autocrine/Paracrine Growth Factor for Human Breast Cancer Acting via the IGF-I Receptor

1989 • 248 citations

Insulin-like growth factor II mRNA expression in human breast cancer.

1988 • 245 citations

Differential Effects of Estrogen and Growth Hormone on Uterine and Hepatic Insulin-Like Growth Factor I Gene Expression in the Ovariectomized Hypophysectomized Rat*

1988 • 236 citations

Insulin-like Growth Factors (IGF) in Muscle Development

1989 • 228 citations

Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding.

1989 • 208 citations

Insulin-Like Growth Factors

1991 • 206 citations

Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver.

1986 • 174 citations

Dexamethasone Inhibits Growth Hormone Induction of Insulin-Like Growth Factor-I (IGF-I) Messenger Ribonucleic Acid (mRNA) in Hypophysectomized Rats and Reduces IGF-I mRNA Abundance in the Intact Rat*

1989 • 174 citations

Insulinlike growth factor binding proteins

1990 • 166 citations

Different Tissue Distribution and Hormonal Regulation of Messenger RNAs Encoding Rat Insulin-Like Growth Factor-Binding Proteins-1 and -2

1990 • 165 citations

Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA

1985 • 155 citations

RAT OVARIAN INSULIN-LIKE GROWTH FACTOR I (IGF-I) GENE EXPRESSION IS GRANULOSA CELL-SELECTIVE: 5′-UNTRANSLATED mRNA VARIANT REPRESENTATION AND HORMONAL REGULATION

1989 • 150 citations

The gene structure of the insulin-like growth factor family

1989 • 143 citations

NUTRITIONALLY-INDUCED CHANGES IN HEPATIC INSULIN-LIKE GROWTH FACTOR I (IGF-I) GENE EXPRESSION IN RATS.

1987 • 140 citations

Insulin-Like Growth Factor Gene Expression during Rat Embryonic Development*

1987 • 118 citations

Insulin-Like Growth Factor I Messenger Ribonucleic Acids with Alternative 5'-Untranslated Regions Are Differentially Expressed during Development of the Rat

1989 • 117 citations

Tumor hypoglycemia: relationship to high molecular weight insulin-like growth factor-II.

1990 • 117 citations

Experimental Diabetes Increases Insulinlike Growth Factor I and II Receptor Concentration and Gene Expression in Kidney

1990 • 112 citations

Developmental Expression of the Tissue Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor in the Rat

1989 • 102 citations

The insulin-like growth factor binding protein BP-25 is expressed by human breast cancer cells

1989 • 61 citations

Coordinate Decrease of Tissue Insulinlike Growth Factor I Posttranscriptional Alternative mRNA Transcripts in Diabetes Mellitus

1989 • 57 citations

Insulin-Like Growth Factor-II in Nonislet Cell Tumors Associated with Hypoglycemia: Increased Levels of Messenger Ribonucleic Acid*

1989 • 55 citations

Regulation of hepatic expression of IGF I and fetal IGF binding protein mRNA in streptozotocin‐diabetic rats

1989 • 46 citations

Dietary Protein Restriction in Artificially Reared Neonatal Rats Causes a Reduction of Insulin-Like Growth Factor-I Gene Expression*

1989 • 45 citations

Nutrition and Somatomedin. XIX. Molecular Regulation of Insulin-Like Growth Factor-1 in Streptozotocin-Diabetic Rats

1988 • 43 citations

METABOLIC EFFECTS OF AN INSULIN‐LIKE FACTOR CAUSING HYPOGLYCAEMIA IN A PATIENT WITH A HAEMANGIOPERICYTOMA

1990 • 40 citations

Experimental diabetes increases insulinlike growth factor I and II receptor concentration and gene expression in kidney

1990 • 37 citations

Coordinate decrease of tissue insulinlike growth factor I posttranscriptional alternative mRNA transcripts in diabetes mellitus

1989 • 25 citations