Cellular Actions and Signaling by Endostatin

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry

1999 • 1,921 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

2000 • 1,536 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

2000 • 1,159 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides

1990 • 710 citations

Combined effects of angiostatin and ionizing radiation in antitumour therapy

1998 • 679 citations

Vasculogenic Mimicry and Tumor Angiogenesis

2000 • 673 citations

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

1998 • 618 citations

Endostatin Induces Endothelial Cell Apoptosis

1999 • 594 citations

Protamine is an inhibitor of angiogenesis

1982 • 582 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

1987 • 491 citations

Canstatin, a Novel Matrix-derived Inhibitor of Angiogenesis and Tumor Growth

2000 • 461 citations

Secreted cathepsin L generates endostatin from collagen XVIII

2000 • 459 citations

Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding

1999 • 451 citations

Interaction of endostatin with integrins implicated in angiogenesis

2001 • 442 citations

Expression and functional significance of VE-cadherin in aggressive human melanoma cells: Role in vasculogenic mimicry

2001 • 440 citations

Anti-angiogenic cues from vascular basement membrane collagen.

2000 • 412 citations

Quantitative angiogenesis assays: Progress and problems

1997 • 386 citations

Generation and degradation of human endostatin proteins by various proteinases

2000 • 379 citations

Continuous release of endostatin from microencapsulated engineered cells for tumor therapy

2001 • 372 citations

Inhibition of tumor angiogenesis mediated by cartilage.

1975 • 361 citations

Lack of collagen XVIII/endostatin results in eye abnormalities

2002 • 349 citations

Distinct Antitumor Properties of a Type IV Collagen Domain Derived from Basement Membrane

2000 • 347 citations

Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin

1998 • 337 citations

The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis.

1993 • 321 citations

Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase.

2000 • 316 citations

Vasostatin, a Calreticulin Fragment, Inhibits Angiogenesis and Suppresses Tumor Growth

1998 • 314 citations

Cell Surface Glypicans Are Low-Affinity Endostatin Receptors

2001 • 310 citations

Local endostatin treatment of gliomas administered by microencapsulated producer cells

2001 • 303 citations

Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene

1999 • 301 citations

The generation of endostatin is mediated by elastase.

1999 • 295 citations

Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion

1999 • 294 citations

Kringle 5 of Plasminogen is a Novel Inhibitor of Endothelial Cell Growth

1997 • 294 citations

Antiangiogenic Activity of Restin, NC10 Domain of Human Collagen XV: Comparison to Endostatin

1999 • 280 citations

Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer

2001 • 276 citations

Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis

2000 • 273 citations

Collagen XVIII, containing an endogenous inhibitor of angiogenesis and tumor growth, plays a critical role in the maintenance of retinal structure and in neural tube closure (Knobloch syndrome)

2000 • 272 citations

Molecular Determinants of Ovarian Cancer Plasticity

2001 • 270 citations

Continuous administration of endostatin by intraperitoneally implanted osmotic pump improves the efficacy and potency of therapy in a mouse xenograft tumor model.

2001 • 259 citations

Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor release

2001 • 246 citations

Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma.

1999 • 246 citations

Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth.

2000 • 228 citations

Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases

2000 • 226 citations

Endostatin Causes G1 Arrest of Endothelial Cells through Inhibition of Cyclin D1

2002 • 216 citations

Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity

2000 • 215 citations

Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin

1999 • 214 citations

Crystal structure of the angiogenesis inhibitor endostatin at 1.5Aresolution

1998 • 209 citations

Antiangiogenesis signals by endostatin

2001 • 198 citations

Cloning, Expression, andin VitroActivity of Human Endostatin

1999 • 188 citations

Suppression of angiogenesis and tumor growth by the inhibitor K1–5 generated by plasmin-mediated proteolysis

1999 • 186 citations

Vasculogenic Mimicry: How Convincing, How Novel, and How Significant?

2000 • 186 citations

Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice.

1999 • 179 citations

The Nc1/Endostatin Domain ofCaenorhabditis elegansType Xviii Collagen Affects Cell Migration and Axon Guidance

2001 • 178 citations

The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing

2000 • 170 citations

Mouse endostatin inhibits the formation of lung and liver metastases.

1999 • 152 citations

TNP-470: an angiogenesis inhibitor in clinical development for cancer

2000 • 143 citations

Angiogenesis assays: problems and pitfalls.

2000 • 139 citations

Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis

2000 • 136 citations

Zinc-dependent dimers observed in crystals of human endostatin

1998 • 133 citations

Clinical trials of antiangiogenic drugs: opportunities, problems, and assessment of initial results.

2001 • 132 citations

Endostatin regulates endothelial cell adhesion and cytoskeletal organization.

2002 • 125 citations

Endostatin Binds Tropomyosin

2001 • 122 citations

PHENOTYPIC CHARACTERIZATION OF HUMAN UMBILICAL VEIN ENDOTHELIAL (ECV304) AND URINARY CARCINOMA (T24) CELLS: ENDOTHELIAL VERSUS EPITHELIAL FEATURES

2001 • 121 citations

Antiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice.

2000 • 120 citations

Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor strategy.

1998 • 119 citations

Heparin-binding fragments of fibronectin are potent inhibitors of endothelial cell growth.

1985 • 118 citations

Zinc-Binding of Endostatin Is Essential for Its Antiangiogenic Activity

1998 • 117 citations

Combination Angiostatin and Endostatin Gene Transfer Induces Synergistic Antiangiogenic Activity in Vitro and Antitumor Efficacy in Leukemia and Solid Tumors in Mice

2001 • 116 citations

Isolation and characterization of the circulating form of human endostatin

1997 • 115 citations

Oligomerization-Dependent Regulation of Motility and Morphogenesis by the Collagen Xviii Nc1/Endostatin Domain

2001 • 114 citations

Angiostatin: an endogenous inhibitor of angiogenesis and of tumor growth.

1997 • 111 citations

Serum endostatin levels are elevated and correlate with serum vascular endothelial growth factor levels in patients with stage IV clear cell renal cancer.

2000 • 110 citations

The Angiogenesis Inhibitor, Endostatin, Does Not Affect Murine Cutaneous Wound Healing

2000 • 108 citations

Molecular biology of breast cancer metastasis Molecular expression of vascular markers by aggressive breast cancer cells

2000 • 104 citations

A strategy to discover circulating angiogenesis inhibitors generated by human tumors.

1995 • 100 citations

Serum endostatin levels are elevated in patients with soft tissue sarcoma

2001 • 97 citations

Antitumor activity of endostatin against carcinogen-induced rat primary mammary tumors.

2000 • 95 citations

Endostatin Inhibits Microvessel Formation in the ex Vivo Rat Aortic Ring Angiogenesis Assay

2000 • 94 citations

Endostatin, an antiangiogenic drug, induces tumor stabilization after chemotherapy or anti-CD20 therapy in a NOD/SCID mouse model of human high-grade non-Hodgkin lymphoma

2000 • 90 citations

Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud

2001 • 90 citations

Tissue examination to monitor antiangiogenic therapy: a phase I clinical trial with endostatin.

2001 • 88 citations

Intravital microscopy reveals novel antivascular and antitumor effects of endostatin delivered locally by alginate-encapsulated cells.

2001 • 86 citations

A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma.

2001 • 86 citations

Inhibitory Effect of Full-Length Human Endostatin on in Vitro Angiogenesis

1999 • 82 citations

Tumor progression is associated with a significant decrease in the expression of the endostatin precursor collagen XVIII in human hepatocellular carcinomas.

2001 • 81 citations

Circulating Angiogenesis Regulators in Cancer Patients

2001 • 80 citations

Endostatin-induced modulation of plasminogen activation with concomitant loss of focal adhesions and actin stress fibers in cultured human endothelial cells.

2001 • 79 citations

Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa-4 murine mammary carcinomas.

2001 • 79 citations

NC1 Domain of Human Type VIII Collagen (α 1) Inhibits Bovine Aortic Endothelial Cell Proliferation and Causes Cell Apoptosis

2001 • 78 citations

Soluble recombinant endostatin purified from Escherichia coli: antiangiogenic activity and antitumor effect.

2001 • 64 citations

Zinc ligand-disrupted recombinant human Endostatin: potent inhibition of tumor growth, safety and pharmacokinetic profile.

1999 • 64 citations

Novel Glycosylated Forms of Human Plasma Endostatin and Circulating Endostatin-Related Fragments of Collagen XV

1999 • 62 citations

Endostatin Binds to Blood Vessels in Situ. Independent of Heparan Sulfate and Does Not Compete for Fibroblast Growth Factor-2 Binding

1999 • 61 citations

Induction of therapeutic antitumor antiangiogenesis by intratumoral injection of genetically engineered endostatin-producing Semliki Forest virus

2001 • 61 citations

Unfulfilled Promise of Endostatin in a Gene Therapy-Xenotransplant Model of Human Acute Lymphocytic Leukemia

2002 • 59 citations

Antitumor interaction of short-course endostatin and ionizing radiation.

2000 • 59 citations

Effect of endostatin on spontaneous tumorigenesis of mammary adenocarcinoma in a transgenic mouse model.

2000 • 58 citations

Intracellular Ca²⁺signaling in endothelial cells by the angiogenesis inhibitors endostatin and angiostatin

2001 • 58 citations

Setbacks for Endostatin

2002 • 57 citations

Continuous Intravascular Secretion of Endostatin in Mice from Transduced Hematopoietic Stem Cells

2002 • 56 citations

Development of lentiviral vectors for antiangiogenic gene delivery

2001 • 53 citations

Effect of Retroviral Endostatin Gene Transfer on Subcutaneous and Intraperitoneal Growth of Murine Tumors

2001 • 52 citations

Stimulation and Inhibition of Angiogenesis in Diabetic Retinopathy

2001 • 49 citations

Clinical studies of angiogenesis inhibitors: The university of texas md anderson center trial of human endostatin

2001 • 46 citations

Intra-tumoral administration of naked plasmid DNA encoding mouse endostatin inhibits renal carcinoma growth

2001 • 43 citations

Circulating levels of endostatin in cancer patients

2001 • 40 citations

Biomarkers of Intrinsic Angiogenic and Anti-angiogenic Activity in Patients with Endometrial Hyperplasia and Endometrial Cancer

2001 • 39 citations

Variable zinc coordination in endostatin

2000 • 36 citations

Purification and characterization of recombinant murine endostatin in E. coli

1999 • 30 citations

Human endostatin inhibits growth of human non-small-cell lung cancer in a murine xenotransplant model

2001 • 30 citations

Autocrine expression of both endostatin and green fluorescent protein provides a synergistic antitumor effect in a murine neuroblastoma model

2001 • 17 citations

Angiogenic cytokines in serum and plasma of patients with head and neck squamous cell carcimona

2000 • 13 citations

What is all the hullabaloo about endostatin?

1999 • 12 citations

Gristle for the mill

1999 • 2 citations