Tissue examination to monitor antiangiogenic therapy: a phase I clinical trial with endostatin.

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Genes Expressed in Human Tumor Endothelium

2000 • 1,838 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

2000 • 1,536 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF

1998 • 1,239 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

Tumor angiogenesis: past, present and the near future

2000 • 973 citations

Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies.

2000 • 750 citations

Vascular endothelial growth factor is essential for corpus luteum angiogenesis

1998 • 641 citations

Endostatin Induces Endothelial Cell Apoptosis

1999 • 594 citations

Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding

1999 • 451 citations

Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms.

2000 • 416 citations

Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor

1998 • 378 citations

Fighting Cancer by Attacking its Blood Supply

1996 • 331 citations

Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase.

2000 • 316 citations

Cell Surface Glypicans Are Low-Affinity Endostatin Receptors

2001 • 310 citations

Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene

1999 • 301 citations

Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction.

1975 • 285 citations

Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis

2000 • 273 citations

Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma.

1999 • 246 citations

Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity

2000 • 215 citations

Crystal structure of the angiogenesis inhibitor endostatin at 1.5Aresolution

1998 • 209 citations

Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice

2000 • 206 citations

Antiangiogenesis signals by endostatin

2001 • 198 citations

Cloning, Expression, andin VitroActivity of Human Endostatin

1999 • 188 citations

The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing

2000 • 170 citations

The Angiogenesis Inhibitor, Endostatin, Does Not Affect Murine Cutaneous Wound Healing

2000 • 108 citations

Inhibitory Effect of Full-Length Human Endostatin on in Vitro Angiogenesis

1999 • 82 citations

Disruption of the KEX1 gene inPichia pastoris allows expression of full-length murine and human endostatin

1999 • 64 citations

Angiogenesis Inhibitor TNP-470 Inhibits Murine Cutaneous Wound Healing

1999 • 63 citations

Endostatin Binds to Blood Vessels in Situ. Independent of Heparan Sulfate and Does Not Compete for Fibroblast Growth Factor-2 Binding

1999 • 61 citations

Angiogenesis inhibitor TNP-470 prevents implanted liver metastases after partial hepatectomy in an experimental model without impairing wound healing

1996 • 23 citations