Structural Elements of an Orphan Nuclear Receptor–DNA Complex

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

The PPARα–leukotriene B4 pathway to inflammation control

1996 • 1,328 citations

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

1995 • 1,089 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

1993 • 745 citations

Nuclear receptor coactivators

1997 • 720 citations

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

1995 • 700 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Structural determinants of nuclear receptor assembly on DNA direct repeats

1995 • 561 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.

1994 • 485 citations

The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily.

1990 • 483 citations

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.

1994 • 470 citations

Determinants for selective RAR and TR recognition of direct repeat HREs.

1993 • 403 citations

The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.

1993 • 397 citations

The solution structure of an HMG-I(Y)–DNA complex defines a new architectural minor groove binding motif

1997 • 372 citations

DNA Binding Properties of Peroxisome Proliferator-activated Receptor Subtypes on Various Natural Peroxisome Proliferator Response Elements

1997 • 367 citations

Cross-validated maximum likelihood enhances crystallographic simulated annealing refinement

1997 • 347 citations

Polarity and Specific Sequence Requirements of Peroxisome Proliferator-activated Receptor (PPAR)/Retinoid X Receptor Heterodimer Binding to DNA

1997 • 342 citations

Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors

1992 • 323 citations

A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.

1989 • 316 citations

Coordination of Drosophila Metamorphosis by Two Ecdysone-Induced Nuclear Receptors

1997 • 293 citations

Novel Sequence Determinants in Peroxisome Proliferator Signaling

1995 • 285 citations

Peroxisome Proliferator-Activated Receptors and Retinoic Acid Receptors Differentially Control the Interactions of Retinoid X Receptor Heterodimers with Ligands, Coactivators, and Corepressors

1997 • 279 citations

Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

1989 • 251 citations

The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase.

1993 • 243 citations

RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.

1994 • 242 citations

Stoichiometric and steric principles governing repression by nuclear hormone receptors.

1997 • 236 citations

A Nuclear Hormone Receptor Corepressor Mediates Transcriptional Silencing by Receptors with Distinct Repression Domains

1996 • 233 citations

The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.

1993 • 218 citations

Orphan nuclear receptors--the first eight years.

1996 • 206 citations

The Monomer-Binding Orphan Receptor Rev-Erb Represses Transcription as a Dimer on a Novel Direct Repeat

1995 • 204 citations

Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation

1993 • 199 citations

The Orphan Receptor Rev-ErbAα Activates Transcription via a Novel Response element

1993 • 199 citations

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors.

1994 • 194 citations

A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor FTZ-F1 and mouse embryonal long terminal repeat-binding protein.

1992 • 191 citations

Exclusive Homodimerization of the Orphan Receptor Hepatocyte Nuclear Factor 4 Defines a New Subclass of Nuclear Receptors

1995 • 187 citations

Mechanisms of transactivation by retinoic acid receptors

1993 • 156 citations

Orphan receptors: in search of a unifying hypothesis for activation.

1992 • 138 citations

A New Orphan Member of the Nuclear Hormone Receptor Superfamily That Interacts with a Subset of Retinoic Acid Response Elements

1994 • 125 citations

Determinants of Target Gene Specificity for RORα1: Monomeric DNA Binding by an Orphan Nuclear Receptor

1995 • 121 citations

A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb.

1994 • 116 citations

Nonbiased identification of DNA sequences that bind thyroid hormone receptor alpha 1 with high affinity.

1993 • 109 citations

Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator.

1994 • 109 citations

Transcriptional Activation and Repression by RORα, an Orphan Nuclear Receptor Required for Cerebellar Development

1997 • 95 citations

Constitutive expression of the orphan receptor, Rev-erbA alpha, inhibits muscle differentiation and abrogates the expression of the myoD gene family.

1995 • 93 citations

The Nonconserved Hinge Region and Distinct Amino-Terminal Domains of the RORα Orphan Nuclear Receptor Isoforms are Required for Proper DNA Bending and RORα-DNA Interactions

1995 • 92 citations

A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb

1994 • 39 citations

Genomic regions required for morphogenesis of the Drosophila embryonic midgut.

1995 • 28 citations

Expression, Purification, and Functional Analysis of the DNA Binding Domain of the Nuclear Receptor Rev-Erbβ

1996 • 7 citations

Molecular Replacement Using Known Structural Information

2003 • 4 citations

Monomeric Nuclear Receptors

1998 • 2 citations