Insulin receptor is phosphorylated in response to treatment of HepG2 cells with insulin-like growth factor I

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

1982 • 709 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.

1982 • 441 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.

1988 • 404 citations

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

1983 • 395 citations

Signal transmission by the insulin-like growth factors

1989 • 380 citations

Hormone families: pancreatic hormones and homologous growth factors

1980 • 375 citations

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

1984 • 299 citations

Insulin-like Growth Factor I Receptor β-Subunit Heterogeneity

1989 • 259 citations

Interactions of Insulin-Like Growth Factors I and II and Multiplication-Stimulating Activity with Receptors and Serum Carrier Proteins

1980 • 254 citations

EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.

1988 • 226 citations

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.

1988 • 226 citations

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.

1987 • 221 citations

Purification and properties of insulin receptors from rat liver membranes

1977 • 188 citations

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.

1987 • 179 citations

Monensin blocks the maturation of receptors for insulin and somatomedin C: Identification of receptor precursors

1983 • 147 citations

Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin.

1985 • 146 citations

Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor.

1981 • 136 citations

Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells.

1987 • 125 citations

Purification of the catalytically active phosphorylated form of insulin receptor kinase by affinity chromatography with O-phosphotyrosyl-binding antibodies

1985 • 124 citations

Characterization of insulin-like growth factor I-stimulated tyrosine kinase activity associated with the beta-subunit of type I insulin-like growth factor receptors of rat liver cells.

1985 • 119 citations

Phosphorylation of receptors for insulin and insulin-like growth factor I. Effects of hormones and phorbol esters.

1986 • 102 citations

Defective internalization of insulin and its receptor in cells expressing mutated insulin receptors lacking kinase activity.

1987 • 97 citations

Interaction of the Monoclonal AntibodiesαlR-1 andαIR-3 with Insulin and Somatomedin-C Receptors

1986 • 78 citations

Dual regulation of glycogen metabolism by insulin and insulin-like growth factors in human hepatoma cells (HEP-G2). Analysis with an anti-receptor monoclonal antibody.

1984 • 73 citations

Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae.

1989 • 64 citations

Effects of inhibitors of N-linked oligosaccharide processing on the biosynthesis and function of insulin and insulin-like growth factor-I receptors.

1988 • 58 citations

Similar control mechanisms regulate the insulin and type I insulin-like growth factor receptor kinases. Affinity-purified insulin-like growth factor I receptor kinase is activated by tyrosine phosphorylation of its beta subunit.

1986 • 57 citations

Insulin and Insulin-like Growth Factor I (IGF I) Stimulate Phosphorylation of a Mr 175,000 Cytoskeleton-associated Protein in Intact FRTL5 Cells

1989 • 41 citations

Phosphorylation of insulin-like growth factor I receptor by the insulin receptor tyrosine kinase in intact cultured skeletal muscle cells

1988 • 36 citations