Molecular Mechanisms of Erythropoietin Signaling

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Cloning and expression of the human erythropoietin gene.

1985 • 1,144 citations

Isolation and characterization of genomic and cDNA clones of human erythropoietin

1985 • 1,101 citations

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1995 • 1,027 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1995 • 961 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

Recombinant Human Erythropoietin in Anemic Patients with End-Stage Renal Disease

1989 • 793 citations

Expression cloning of the murine erythropoietin receptor

1989 • 776 citations

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

1993 • 655 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change

1999 • 624 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells.

1990 • 574 citations

Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.

1994 • 574 citations

Targeted disruption ofSHIPleads to hemopoietic perturbations, lung pathology, and a shortened life span

1998 • 566 citations

Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization

1988 • 464 citations

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

1996 • 439 citations

Homodimerization and constitutive activation of the erythropoietin receptor.

1992 • 326 citations

Interaction of the erythropoietin and stem-cell-factor receptors

1995 • 309 citations

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.

1995 • 291 citations

Use of Recombinant Human Erythropoietin Outside the Setting of Uremia

1997 • 269 citations

Erythropoietin receptor characteristics on primary human erythroid cells

1991 • 249 citations

Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway.

1996 • 224 citations

Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.

1995 • 224 citations

Biology of erythropoietin.

1998 • 207 citations

Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

1996 • 204 citations

Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

1993 • 203 citations

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.

1994 • 201 citations

Localization of cells producing erythropoietin in murine liver by in situ hybridization [see comments]

1991 • 199 citations

Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.

1995 • 193 citations

Murine erythropoietin gene: cloning, expression, and human gene homology.

1986 • 193 citations

Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation

1991 • 188 citations

Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites

1995 • 187 citations

Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor.

1996 • 181 citations

The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells

1995 • 179 citations

Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway

1998 • 174 citations

Calcium/calmodulin inhibition of basic-helix-loop-helix transcription factor domains

1994 • 170 citations

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT

1997 • 158 citations

Involvement of SH2-containing Phosphotyrosine Phosphatase Syp in Erythropoietin Receptor Signal Transduction Pathways

1995 • 147 citations

Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3-Kinase and for EpR-associated PI 3-Kinase Activity

1995 • 146 citations

Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells.

1992 • 139 citations

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor

1993 • 133 citations

Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor

1994 • 131 citations

Expression of specific high-affinity binding sites for erythropoietin on rat and mouse megakaryocytes.

1989 • 129 citations

Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1.

1994 • 123 citations

The Role of Tyrosine Phosphorylation in Proliferation and Maturation of Erythroid Progenitor Cells

1997 • 122 citations

Erythropoietin Induces the Tyrosine Phosphorylation of GAB1 and Its Association With SHC, SHP2, SHIP, and Phosphatidylinositol 3-Kinase

1999 • 113 citations

Saturation Mutagenesis of the WSXWS Motif of the Erythropoietin Receptor

1996 • 111 citations

Receptors for erythropoietin in mouse and human erythroid cells and placenta

1989 • 111 citations

Activation of JNK Signaling Pathway by Erythropoietin, Thrombopoietin, and Interleukin-3

1997 • 110 citations

Erythropoietin Induces the Tyrosine Phosphorylation of Insulin Receptor Substrate-2

1997 • 105 citations

Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment.

1980 • 101 citations

Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis

1996 • 100 citations

Erythropoietin and Interleukin-3 Activate Tyrosine Phosphorylation of CBL and Association With CRK Adaptor Proteins

1997 • 97 citations

Trends in anemia treatment with erythropoietin usage and patient outcomes

1998 • 96 citations

Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product in human erythropoietin-responsive cells

1993 • 94 citations

Erythropoietin stimulates a rise in intracellular free calcium concentration in single early human erythroid precursors.

1988 • 91 citations

Erythropoietin induces the association of phosphatidylinositol 3′‐kinase with a tyrosine‐phosphorylated protein complex containing the erythropoietin receptor

1993 • 88 citations

Cloning of the human erythropoietin receptor gene

1991 • 87 citations

Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line.

1994 • 86 citations

Association of the p85 regulatory subunit of phosphatidylinositol 3- kinase with an essential erythropoietin receptor subdomain

1993 • 85 citations

Erythropoietin-induced Recruitment of Shc via a Receptor Phosphotyrosine-independent, Jak2-associated Pathway

1995 • 84 citations

Erythropoietin stimulates a rise in intracellular-free calcium concentration in single BFU-E derived erythroblasts at specific stages of differentiation

1989 • 78 citations

Erythropoietin stimulates 45Ca2+ uptake in Friend virus-infected erythroid cells.

1984 • 76 citations

Erythropoiesis in vitro. Role of calcium.

1979 • 73 citations

Early events in erythropoietin-induced signaling.

1996 • 70 citations

Coordinate expression and developmental role of Id2 protein and TAL1/E2A heterodimer in erythroid progenitor differentiation

1995 • 70 citations

NF-κB Transcription Factors Are Involved in Normal Erythropoiesis

1998 • 68 citations

The box1 Domain of the Erythropoietin Receptor Specifies Janus Kinase 2 Activation and Functions Mitogenically within an Interleukin 2 β-Receptor Chimera

1996 • 67 citations

The Signal Transduction Pathway of Erythropoietin Involves Three Forms of Mitogen‐Activated Protein (MAP) Kinase in UT7 Erythroleukemia Cells

1995 • 66 citations

Identification of the Erythropoietin Receptor Domain Required for Calcium Channel Activation

1999 • 64 citations

“Benign erythrocytosis” and other familial and congenital polycythemias

1996 • 61 citations

The extended box 2 subdomain of erythropoietin receptor is nonessential for Jak2 activation yet critical for efficient mitogenesis in FDC-ER cells

1994 • 61 citations

Signal transduction by the erythropoietin receptor: evidence for the activation of phospholipases A2 and C

1992 • 56 citations

Bcl-3 Expression and Nuclear Translocation Are Induced by Granulocyte-Macrophage Colony-Stimulating Factor and Erythropoietin in Proliferating Human Erythroid Precursors

1998 • 55 citations

Erythropoietin Activates Raf1 by an Shc-Independent Pathway in CTLL-EPO-R Cells

1997 • 53 citations

Modulation of Calcium Channels in Human Erythroblasts by Erythropoietin

1997 • 52 citations

A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation

1999 • 51 citations

Cloning of the gene encoding the human erythropoietin receptor

1991 • 50 citations

Calcium influx in induced differentiation of murine erythroleukemia cells

1993 • 50 citations

Three-dimensional intracellular calcium gradients in single human burst-forming units-erythroid-derived erythroblasts induced by erythropoietin.

1990 • 48 citations

Rapid activation by erythropoietin of protein kinase C in nuclei of erythroid progenitor cells

1990 • 46 citations

Activation of Hematopoietic Progenitor Kinase-1 by Erythropoietin

1999 • 45 citations

Activation of 70‐kDa S6 kinase, induced by the cytokines interleukin‐3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation

1994 • 45 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 43 citations

Induction of a Ca2+, Mg2+-dependent endonuclease activity during the early stages of murine erythroleukemic cell differentiation.

1984 • 38 citations

Calcium ionophore, A23187, induces commitment to differentiation but inhibits the subsequent expression of erythroid genes in murine erythroleukemia cells

1991 • 35 citations

Tyrosine Residues within the Intracellular Domain of the Erythropoietin Receptor Mediate Activation of AP-1 Transcription Factors

1998 • 35 citations

Ion channels in human erythroblasts. Modulation by erythropoietin.

1992 • 35 citations

Erythropoietin induces rapid increases in intracellular free calcium in human bone marrow cells.

1988 • 34 citations

Erythropoietin Receptor and STAT5-Specific Pathways Promote SKT6 Cell Hemoglobinization

1998 • 34 citations

Role of pertussis toxin-sensitive guanosine triphosphate-binding proteins in the response of erythroblasts to erythropoietin

1991 • 29 citations

Physical and Functional Interaction between p72 and Erythropoietin Receptor

1998 • 29 citations

c-myc expression affects proliferation but not terminal differentiation or survival of explanted erythroid progenitor cells

1996 • 25 citations

The ontogeny of the biological role and production of erythropoietin

1995 • 24 citations

Expression of SCL Is Normal in Transfusion-Dependent Diamond-Blackfan Anemia But Other bHLH Proteins Are Deficient

1997 • 24 citations

Erythropoietin activation of AP1 (Fos/Jun).

1995 • 24 citations

Erythropoietin modulation of intracellular calcium: a role for tyrosine phosphorylation

1994 • 24 citations

The role of cAMP and calcium in the stimulation of proliferation of immature erythroblasts by erythropoietin

1987 • 23 citations

Ca2+/Calmodulin-dependent and -independent Down-regulation of c-myb mRNA Levels in Erythropoietin-responsive Murine Erythroleukemia Cells

1996 • 22 citations

Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, inhibits erythropoietin-induced erythroid differentiation of K562 cells.

1996 • 22 citations

G-protein alpha subunit Gi(alpha)2 mediates erythropoietin signal transduction in human erythroid precursors.

1996 • 21 citations