Erythropoietin induces the association of phosphatidylinositol 3′‐kinase with a tyrosine‐phosphorylated protein complex containing the erythropoietin receptor

Oncogenes and signal transduction

1991 • 2,816 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Erythropoietin

1991 • 852 citations

Expression cloning of the murine erythropoietin receptor

1989 • 776 citations

Purification and characterization of phosphoinositide 3-kinase from rat liver.

1990 • 640 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

Phosphoinositide kinases

1990 • 331 citations

Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival.

1991 • 309 citations

Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation

1987 • 307 citations

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

1991 • 297 citations

Signal transduction of the human granulocyte-macrophage colony- stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins

1990 • 294 citations

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

1991 • 264 citations

Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase

1992 • 240 citations

Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.

1991 • 231 citations

Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines.

1988 • 222 citations

IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells.

1992 • 191 citations

Phosphoinositide 3-kinase: A new effector in signal transduction?

1991 • 166 citations

Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase

1991 • 166 citations

Erythropoietin receptor. Subunit structure and activation.

1990 • 166 citations

A specific combination of substrates is involved in signal transduction by the kit-encoded receptor.

1991 • 155 citations

Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines

1992 • 128 citations

In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130.

1992 • 127 citations

IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase.

1991 • 126 citations

Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells.

1992 • 124 citations

Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates.

1988 • 117 citations

Proliferative action of erythropoietin is associated with rapid protein tyrosine phosphorylation in responsive B6SUt.EP cells.

1991 • 115 citations

Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line.

1992 • 103 citations

Interleukin 2- and Polyomavirus Middle T Antigen-Induced Modification of Phosphatidylinositol 3-Kinase Activity in Activated T Lymphocytes

1991 • 98 citations

Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor.

1991 • 97 citations

The erythropoietin receptor of rat erythroid progenitor lens. Characterization and affinity cross-linkage.

1987 • 93 citations

Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors.

1991 • 90 citations

Structure of the murine erythropoietin receptor complex. Characterization of the erythropoietin cross-linked proteins.

1991 • 77 citations

Multimeric structure of the membrane erythropoietin receptor of murine erythroleukemia cells (Friend cells). Cross-linking of erythropoietin with the spleen focus-forming virus envelope protein

1991 • 76 citations

Protein tyrosine phosphorylation associated with activation of the interleukin 2 receptor.

1990 • 75 citations

Granulocyte-macrophage colony-stimulating factor and erythropoietin act competitively to induce two different programs of differentiation in the human pluripotent cell line UT-7

1992 • 61 citations

Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes.

1991 • 58 citations

Association of the erythropoietin receptor with protein tyrosine kinase activity.

1992 • 56 citations

Erythropoietin rapidly induces tyrosine phosphorylation in the human erythropoietin-dependent cell line, UT-7

1992 • 48 citations

Solubilization and hydrodynamic characteristics of the erythropoietin receptor

1990 • 28 citations

Characterization of a tyrosine kinase activity associated with the high-affinity interleukin 2 receptor complex

1992 • 15 citations