Identification of the Erythropoietin Receptor Domain Required for Calcium Channel Activation

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Cytokine receptor signalling

1995 • 1,242 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1995 • 961 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Expression cloning of the murine erythropoietin receptor

1989 • 776 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Targeted disruption ofSHIPleads to hemopoietic perturbations, lung pathology, and a shortened life span

1998 • 566 citations

Rapid Ca2+-mediated activation of Rap1 in human platelets

1997 • 401 citations

The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation

1998 • 330 citations

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

1991 • 297 citations

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.

1995 • 291 citations

The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl

1995 • 235 citations

Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.

1995 • 224 citations

Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.

1996 • 206 citations

Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

1996 • 204 citations

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.

1994 • 201 citations

Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites

1995 • 187 citations

The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells

1995 • 179 citations

Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway

1998 • 174 citations

Calcium/calmodulin inhibition of basic-helix-loop-helix transcription factor domains

1994 • 170 citations

Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo

1994 • 165 citations

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT

1997 • 158 citations

Involvement of SH2-containing Phosphotyrosine Phosphatase Syp in Erythropoietin Receptor Signal Transduction Pathways

1995 • 147 citations

Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3-Kinase and for EpR-associated PI 3-Kinase Activity

1995 • 146 citations

Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells.

1992 • 139 citations

Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo

1994 • 135 citations

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor

1993 • 133 citations

Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor

1994 • 131 citations

The Role of Tyrosine Phosphorylation in Proliferation and Maturation of Erythroid Progenitor Cells

1997 • 122 citations

Saturation Mutagenesis of the WSXWS Motif of the Erythropoietin Receptor

1996 • 111 citations

Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment.

1980 • 101 citations

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor

1993 • 101 citations

Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis

1996 • 100 citations

Activation of the Small GTPase Rap1 in Human Neutrophils

1998 • 98 citations

Erythropoietin and Interleukin-3 Activate Tyrosine Phosphorylation of CBL and Association With CRK Adaptor Proteins

1997 • 97 citations

Changes in Intracellular Ca²⁺ and Energy Levels During In Vitro Ischemia in the Gerbil Hippocampal Slice

1994 • 97 citations

Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product in human erythropoietin-responsive cells

1993 • 94 citations

Erythropoietin stimulates a rise in intracellular free calcium concentration in single early human erythroid precursors.

1988 • 91 citations

Cloning of the human erythropoietin receptor gene

1991 • 87 citations

Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line.

1994 • 86 citations

Association of the p85 regulatory subunit of phosphatidylinositol 3- kinase with an essential erythropoietin receptor subdomain

1993 • 85 citations

Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription.

1995 • 85 citations

Physical and functional interactions between Stat5 and the tyrosine- phosphorylated receptors for erythropoietin and interleukin-3

1996 • 82 citations

Erythropoietin receptor-operated Ca2+ channels: Activation by phospholipase C-γ1

1998 • 80 citations

Erythropoietin stimulates a rise in intracellular-free calcium concentration in single BFU-E derived erythroblasts at specific stages of differentiation

1989 • 78 citations

Erythropoietin stimulates 45Ca2+ uptake in Friend virus-infected erythroid cells.

1984 • 76 citations

Erythropoiesis in vitro. Role of calcium.

1979 • 73 citations

Early events in erythropoietin-induced signaling.

1996 • 70 citations

Coordinate expression and developmental role of Id2 protein and TAL1/E2A heterodimer in erythroid progenitor differentiation

1995 • 70 citations

NF-κB Transcription Factors Are Involved in Normal Erythropoiesis

1998 • 68 citations

Erythropoietin and interleukin-2 activate distinct JAK kinase family members.

1994 • 57 citations

Identification of a Critical Ligand Binding Determinant of the Human Erythropoietin Receptor

1996 • 55 citations

Bcl-3 Expression and Nuclear Translocation Are Induced by Granulocyte-Macrophage Colony-Stimulating Factor and Erythropoietin in Proliferating Human Erythroid Precursors

1998 • 55 citations

Modulation of Calcium Channels in Human Erythroblasts by Erythropoietin

1997 • 52 citations

Dimer- and Oligomerization of the Erythropoietin Receptor by Disulfide Bond Formation and Significance of the Region Near the WSXWS Motif in Intracellular Transport

1993 • 51 citations

Cloning of the gene encoding the human erythropoietin receptor

1991 • 50 citations

Calcium influx in induced differentiation of murine erythroleukemia cells

1993 • 50 citations

Three-dimensional intracellular calcium gradients in single human burst-forming units-erythroid-derived erythroblasts induced by erythropoietin.

1990 • 48 citations

Modulation of Calcium Channels in Human Erythroblasts by Erythropoietin

1997 • 47 citations

Bcl-3 Expression and Nuclear Translocation Are Induced by Granulocyte-Macrophage Colony-Stimulating Factor and Erythropoietin in Proliferating Human Erythroid Precursors

1998 • 47 citations

Induction of a Ca2+, Mg2+-dependent endonuclease activity during the early stages of murine erythroleukemic cell differentiation.

1984 • 38 citations

Short term effect of prolactin on intracellular calcium in Chinese hamster ovary cells stably transfected with prolactin receptor complementary deoxyribonucleic acid.

1994 • 37 citations

Calcium ionophore, A23187, induces commitment to differentiation but inhibits the subsequent expression of erythroid genes in murine erythroleukemia cells

1991 • 35 citations

Ion channels in human erythroblasts. Modulation by erythropoietin.

1992 • 35 citations

Erythropoietin induces rapid increases in intracellular free calcium in human bone marrow cells.

1988 • 34 citations

Regulation of transmembrane signal transduction of insulin-like growth factor II by competence type growth factors or viral ras p21.

1991 • 34 citations

Suppression of presynaptic calcium influx by metabotropic glutamate receptor agonists in neonatal rat hippocampus

1995 • 32 citations

Role of pertussis toxin-sensitive guanosine triphosphate-binding proteins in the response of erythroblasts to erythropoietin

1991 • 29 citations

Expression of SCL Is Normal in Transfusion-Dependent Diamond-Blackfan Anemia But Other bHLH Proteins Are Deficient

1997 • 24 citations

Erythropoietin modulation of intracellular calcium: a role for tyrosine phosphorylation

1994 • 24 citations

Ca2+/Calmodulin-dependent and -independent Down-regulation of c-myb mRNA Levels in Erythropoietin-responsive Murine Erythroleukemia Cells

1996 • 22 citations

G-protein alpha subunit Gi(alpha)2 mediates erythropoietin signal transduction in human erythroid precursors.

1996 • 21 citations