In Vitro Inhibition of Insulin Release by Blood Mononuclear Cells from Insulin-Dependent Diabetic and Healthy Subjects: Synergistic Action of IL-1 and TNF

Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.

1987 • 305 citations

Does Nitric Oxide Mediate Autoimmune Destruction of β-Cells?: Possible Therapeutic Interventions in IDDM

1992 • 299 citations

Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1

1988 • 296 citations

Endotoxin‐Stimulated Human Monocyte Secretion of Interleukin 1, Tumour Necrosis Factor Alpha, and Prostaglandin E₂ Shows Stable Interindividual Differences

1988 • 266 citations

REPRODUCIBLE HIGH YIELD OF RAT ISLETS BY STATIONARY IN VITRO DIGESTION FOLLOWING PANCREATIC DUCTAL OR PORTAL VENOUS COLLAGENASE INJECTION1

1987 • 220 citations

Cytokines Cause Functional and Structural Damage to Isolated Islets of Langerhans

1985 • 180 citations

A Tumour Necrosis Factor Beta Gene Polymorphism in Relation to Monokine Secretion and Insulin‐Dependent Diabetes Mellitus

1991 • 156 citations

Cytotoxic effects of cytokines on rat islets: Evidence for involvement of free radicals and lipid peroxidation

1992 • 142 citations

Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

1987 • 92 citations

Heat shock protein induction in rat pancreatic islets by recombinant human interleukin 1?

1991 • 85 citations

Lymphocytes from diabetics suppress insulin releasein vitro

1981 • 81 citations

Interleukin 1 Inhibits Insulin Secretion From Isolated Perifused Rat Islets

1986 • 79 citations

Mechanisms of Pancreatic Islet Cell Destruction Dose‐Dependent Cytotoxic Effect of Soluble Blood Mononuclear Cell Mediators on Isolated Islets of Langerhans

1986 • 76 citations

In vitro inhibition of pancreatic B cell function by lymphocytes from diabetics with associated autoimmune diseases: a T cell phenomenon.

1982 • 66 citations

Interleukin 1 induces new protein formation in isolated rat islets of Langerhans

1989 • 31 citations

Intrinsic cytotoxicity of natural killer cells to pancreatic islets in vitro

1990 • 26 citations

Cell-mediated immune reactions against B cells and defect of suppressor cell activity in Type 1 (insulin-dependent) diabetes mellitus

1986 • 23 citations

Comparison of Biological and Immunological Activities of Human Monocyte‐Derived Interleukin 1β and Human Recombinant Interleukin 1β

1990 • 13 citations

Effect of Media Conditioned by Concanavalin A Activated Spleen Cells on Pancreatic Islet Cells.

1991 • 1 citations

Interaction between peripheral blood mononuclears and islet cells in vitro

1991 • 1 citations