The dependence receptors DCC and UNC5H as a link between neuronal guidance and survival

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Rho GTPases in cell biology

2002 • 4,662 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6

1994 • 1,346 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

1994 • 1,311 citations

Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System

1996 • 1,253 citations

Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor

1996 • 982 citations

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans

1990 • 909 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

Chemotropic Responses of Retinal Growth Cones Mediated by Rapid Local Protein Synthesis and Degradation

2001 • 772 citations

Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

1997 • 764 citations

Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer

1994 • 708 citations

RETRACTED: A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion

1999 • 686 citations

Chemotropic guidance of developing axons in the mammalian central nervous system

1988 • 681 citations

The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance

2003 • 628 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

RETRACTED: Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex

2001 • 603 citations

The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons

1995 • 566 citations

cAMP-Dependent Growth Cone Guidance by Netrin-1

1997 • 550 citations

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

2001 • 544 citations

Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors

1997 • 511 citations

UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans

1992 • 503 citations

UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues

1996 • 491 citations

Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1

1999 • 478 citations

The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

1998 • 415 citations

Adaptation in the chemotactic guidance of nerve growth cones

2002 • 407 citations

Adenosine A2B receptors.

1997 • 407 citations

UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans

1992 • 404 citations

Calcium signalling in the guidance of nerve growth by netrin-1

2000 • 380 citations

The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein

1997 • 372 citations

Netrin-1 acts as a survival factor via its receptors UNC5H and DCC

2001 • 325 citations

Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic Hedgehog

2003 • 315 citations

How cells die: Apoptosis pathways☆☆☆

2001 • 313 citations

Mad-related genes in the human

1996 • 308 citations

Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones

2003 • 289 citations

Phospholipase C-γ and Phosphoinositide 3-Kinase Mediate Cytoplasmic Signaling in Nerve Growth Cone Guidance

1999 • 281 citations

Turning of Retinal Growth Cones in a Netrin-1 Gradient Mediated by the Netrin Receptor DCC

1997 • 280 citations

Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation

2002 • 263 citations

Extension of Long Leading Processes and Neuronal Migration in the Mammalian Brain Directed by the Chemoattractant Netrin-1

1999 • 259 citations

The Netrin Receptor UNC-40/DCC Stimulates Axon Attraction and Outgrowth through Enabled and, in Parallel, Rac and UNC-115/AbLIM

2003 • 249 citations

Kennedy's Disease

1999 • 243 citations

Directional Guidance of Oligodendroglial Migration by Class 3 Semaphorins and Netrin-1

2002 • 238 citations

RETRACTED: Binding of DCC by Netrin-1 to Mediate Axon Guidance Independent of Adenosine A2B Receptor Activation

2001 • 237 citations

The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease

2000 • 233 citations

The DCC Gene: Structural Analysis and Mutations in Colorectal Carcinomas

1994 • 224 citations

Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor

2000 • 216 citations

Loss of heterozygosity involves multiple tumor suppressor genes in human esophageal cancers.

1992 • 215 citations

Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system

2000 • 215 citations

Frequent loss of heterozygosity at the DCC locus in gastric cancer.

1992 • 204 citations

The Netrin-1 Receptor DCC Promotes Filopodia Formation and Cell Spreading by Activating Cdc42 and Rac1

2002 • 203 citations

The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

2001 • 202 citations

Rac1 and Cdc42 but Not RhoA or Rho Kinase Activities Are Required for Neurite Outgrowth Induced by the Netrin-1 Receptor DCC (Deleted in Colorectal Cancer) in N1E-115 Neuroblastoma Cells

2002 • 197 citations

Age-related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway

2002 • 193 citations

DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study

2002 • 188 citations

The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment

2003 • 185 citations

Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas

2003 • 184 citations

Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18

1991 • 184 citations

Floor Plate and Netrin-1 Are Involved in the Migration and Survival of Inferior Olivary Neurons

1999 • 182 citations

The Netrin 1 ReceptorsUnc5h3andDccAre Necessary at Multiple Choice Points for the Guidance of Corticospinal Tract Axons

2002 • 181 citations

The NTR module: Domains of netrins, secreted frizzled related proteins, and type I procollagen C‐proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases

1999 • 180 citations

p53RDL1 regulates p53-dependent apoptosis

2003 • 161 citations

A Novel Member of the Netrin Family, β-Netrin, Shares Homology with the β Chain of Laminin

2000 • 156 citations

Complementary expression and neurite outgrowth activity of netrin-G subfamily members

2002 • 143 citations

Guidance of glial precursor cell migration by secreted cues in the developing optic nerve

2001 • 143 citations

Netrin-3, a Mouse Homolog of Human NTN2L, Is Highly Expressed in Sensory Ganglia and Shows Differential Binding to Netrin Receptors

1999 • 140 citations

Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma

1993 • 137 citations

Chromosome 18q allelic loss and prognosis in stage II and III colon cancer

1998 • 136 citations

Quantification of expression of netrins, slits and their receptors in human prostate tumors

2002 • 133 citations

Role of the Dependence Receptor DCC in Colorectal Cancer Pathogenesis

2004 • 129 citations

Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary

1998 • 124 citations

Mediation of the DCC Apoptotic Signal by DIP13α

2002 • 114 citations

Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal

2003 • 113 citations

UNC5H1 Induces Apoptosis via Its Juxtamembrane Region through an Interaction with NRAGE

2003 • 111 citations

Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans

2000 • 102 citations

Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues.

1994 • 98 citations

Apoptosis and Dependence Receptors: A Molecular Basis for Cellular Addiction

2004 • 96 citations

Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer

1993 • 91 citations

p75NTR and the concept of cellular dependence: seeing how the other half die

1998 • 91 citations

A Role of Netrin-1 in the Formation of the Subcortical Structure Striatum: Repulsive Action on the Migration of Late-Born Striatal Neurons

2001 • 89 citations

Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation

2002 • 89 citations

Allelotype analysis of oesophageal adenocarcinoma: loss of heterozygosity occurs at multiple sites

1998 • 87 citations

Genetic alterations in localized prostate cancer: Identification of a common region of deletion on chromosome arm 18q

1994 • 84 citations

Somatic genetic changes on chromosome 18 in breast carcinomas: is the DCC gene involved?

1991 • 80 citations

Loss of heterozygosity on chromosome 18q is associated with muscle-invasive transitional cell carcinoma of the bladder

1994 • 75 citations

UNC-5 Function Requires Phosphorylation of Cytoplasmic Tyrosine 482, but Its UNC-40-Independent Functions also Require a Region between the ZU-5 and Death Domains

2002 • 74 citations

Induction of apoptosis and G2/M cell cycle arrest by DCC

1999 • 72 citations

Netrin Stimulates Tyrosine Phosphorylation of the UNC-5 Family of Netrin Receptors and Induces Shp2 Binding to the RCM Cytodomain

2001 • 70 citations

Loss of DCC expression and glioma progression.

1997 • 70 citations

Chromosomal deletions and K‐ras gene mutations in human endometrial carcinomas

1992 • 68 citations

Expression of DCC Protein in Colorectal Tumors and Its Relationship to Tumor Progression and Metastasis

1999 • 66 citations

Expression of the Deleted in Colorectal Cancer Gene Is Related to Prognosis in DNA Diploid and Low Proliferative Colorectal Adenocarcinoma

1999 • 63 citations

Identification of Domains of Netrin UNC-6 that Mediate Attractive and Repulsive Guidance and Responses from Cells and Growth Cones

2002 • 60 citations

DCC expression is altered by multiple mechanisms in brain tumours.

1995 • 48 citations

Expression of the tumor suppressor gene DCC in human gliomas.

1993 • 48 citations

Alteration of the DCC tumor-suppressor gene in tumorigenic HPV-18 immortalized human keratinocytes transformed by nitrosomethylurea.

1993 • 47 citations

Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors.

1994 • 45 citations

Alterations in the deleted in colorectal carcinoma gene in human primary leukemia

1993 • 44 citations

DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18

1993 • 44 citations

Loss of heterozygosity and loss of expression of the DCC gene in gastric cancer

1998 • 43 citations

Loss of expression and loss of heterozygosity in the DCC gene in neoplasms of the human female reproductive tract

1995 • 43 citations

Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

1997 • 41 citations

DCC gene alteration in human endometrial carcinomas

1994 • 37 citations

Suppressed tumorigenicity of human endometrial cancer cells by the restored expression of the DCC gene

2000 • 35 citations

A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion

2022 • 35 citations

p53, DCC and thymidylate synthase as predictors of survival after resection of hepatic metastases from colorectal cancer

2002 • 34 citations

Alterations in the deleted in colorectal carcinoma gene in human primary leukemia

1993 • 34 citations

Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene

1999 • 31 citations

Loss of DCC gene expression during ovarian tumorigenesis: relation to tumour differentiation and progression

2000 • 26 citations

Decreased DCC mRNA expression in human gastric cancers is clinicopathologically significant

1998 • 24 citations

Loss of expression of the gene deleted in colon carcinoma (DCC) is closely related to histologic differentiation and lymph node metastasis in endometrial carcinoma

1999 • 24 citations

Analysis of the DCC Tumor Suppressor Gene in Testicular Germ Cell Tumors: Mutations and Loss of Expression

1997 • 20 citations

Status of deleted in colorectal cancer gene expression correlates with neuroblastoma metastasis.

1998 • 19 citations

Modulation of Giα2 signaling by the axonal guidance molecule UNC5H2

2002 • 17 citations

The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C elegans

1990 • 15 citations

Chromosome 18q allelic loss and prognosis in stage II and III colon cancer

1998 • 14 citations

The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons

1995 • 12 citations

Expression of the DCC Gene in Human Hematological Malignancies

1994 • 11 citations

alterations of the tumour suppressor gene DCC in Neuroblastoma

1997 • 8 citations

UNC-5 Function Requires Phosphorylation of Cytoplasmic Tyrosine 482, but Its UNC-40-Independent Functions also Require a Region between the ZU-5 and Death Domains

2002 • 6 citations

Decreased DCC mRNA expression in human gastric cancers is clinicopathologically significant

1998 • 4 citations

DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18

1993 • 3 citations

Chromosomal deletions and K-ras gene mutations in human endometrial carcinomas

1994 • 2 citations