Neurturin and GDNF Promote Proliferation and Survival of Enteric Neuron and Glial Progenitorsin Vitro

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

1979 • 2,285 citations

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

1993 • 1,941 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC

1993 • 1,273 citations

Renal and neuronal abnormalities in mice lacking GDNF

1996 • 1,260 citations

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1996 • 1,208 citations

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

1996 • 1,170 citations

Defects in enteric innervation and kidney development in mice lacking GDNF

1996 • 1,169 citations

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

1994 • 1,140 citations

The Enteric Nervous System

2016 • 1,113 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

1994 • 1,000 citations

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

1994 • 934 citations

A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease

1994 • 886 citations

Expression of the c-ret proto-oncogene during mouse embryogenesis

1993 • 831 citations

The migration of neural crest cells to the wall of the digestive tract in avian embryo

1973 • 824 citations

GDNF signalling through the Ret receptor tyrosine kinase

1996 • 809 citations

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1996 • 795 citations

Mutations of the RET proto-oncogene in Hirschsprung's disease

1994 • 751 citations

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

1996 • 711 citations

Experimental analysis of the migration and differentiation of neuroblasts of the autonomic nervous system and of neurectodermal mesenchymal derivatives, using a biological cell marking technique

1974 • 651 citations

Single missense mutation in the tyrosine kinasecatalytic domain of the RET protooncogene is associated with multiple endocrineneoplasia type 2B.

1994 • 591 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours

1994 • 531 citations

Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

1998 • 499 citations

Glial growth factor restricts mammalian neural crest stem cells to a glial fate

1994 • 496 citations

2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca ²⁺ -Mediated Endonuclease Activation

1988 • 460 citations

The origin of intrinsic ganglia of trunk viscera from vagal neural crest in the chick embryo

1954 • 431 citations

Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts

1996 • 409 citations

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

1997 • 397 citations

Glial cells in the enteric nervous system contain glial fibrillary acidic protein

1980 • 379 citations

TrnR2, a Novel Receptor That Mediates Neurturin and GDNF Signaling through Ret

1997 • 357 citations

Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins

1997 • 302 citations

Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient

1996 • 277 citations

Chemical coding of neurons in the myenteric plexus and external muscle of the small and large intestine of the mouse

1996 • 263 citations

Neurturin and Glial Cell Line-Derived Neurotrophic Factor Receptor-β (GDNFR-β), Novel Proteins Related to GDNF and GDNFR-α with Specific Cellular Patterns of Expression Suggesting Roles in the Developing and Adult Nervous System and in Peripheral Organs

1997 • 256 citations

Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis.

1996 • 237 citations

Time of origin of neurons in the murine enteric nervous system: Sequence in relation to phenotype

1991 • 234 citations

Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

1997 • 226 citations

Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence

1996 • 225 citations

Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture.

1996 • 199 citations

Germline mutations of the RET ligand GDNF are not sufficient to cause Hirschsprung disease

1996 • 194 citations

Cholinergic differentiation of presumptive adrenergic neuroblasts in interspecific chimeras after heterotopic transplantations.

1975 • 181 citations

Vital dye labelling demonstrates a sacral neural crest contribution to the enteric nervous system of chick and mouse embryos

1991 • 177 citations

Postmigratory neural crest cells expressing c-RET display restricted developmental and proliferative capacities

1995 • 169 citations

Glial Cell Line-derived Neurotrophic Factor Signals through the RET Receptor and Activates Mitogen-activated Protein Kinase

1996 • 168 citations

Genes and lineages in the formation of the enteric nervous system

1997 • 165 citations

Neurites Can Remain Viable after Destruction of the Neuronal Soma by Programmed Cell Death (Apoptosis)

1994 • 154 citations

Phenotypic expression in the developing murine enteric nervous system

1982 • 151 citations

Colonization of the post-umbilical bowel by cells derived from the sacral neural crest: direct tracing of cell migration using an intercalating probe and a replication-deficient retrovirus

1991 • 144 citations

De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease

1996 • 143 citations

Endothelin-B receptor is expressed by neural crest cells in the avian embryo.

1996 • 113 citations

Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha

1997 • 94 citations

Developmental potential of neural crest-derived cells migrating from segments of developing quail bowel back-grafted into younger chick host embryos

1990 • 85 citations

Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts

1995 • 84 citations

Neural Crest-Derived Cells Isolated from the Gut by Immunoselection DeveLop Neuronal and Glial Phenotypes When Cultured on Laminin

1993 • 71 citations

Aggregation chimeras demonstrate that the primary defect responsible for aganglionic megacolon in lethal spotted mice is not neuroblast autonomous

1993 • 53 citations

Developmental Potentials of Enteric Neural Crest-Derived Cells in Clonal and Mass Cultures

1994 • 53 citations

Developmental potentialities of cells derived from the truncal neural crest in clonal cultures

1992 • 50 citations

The enteric nervous system

1993 • 49 citations

Control of peripheral glial cell proliferation: A comparison of the division rates of enteric glia and Schwann cells and their response to mitogens

1987 • 35 citations

Isolation, identification, and culture of normal mouse colonic glia

1994 • 28 citations

Regional differences between various axial segments of the avian neural crest regarding the formation of enteric ganglia

1993 • 16 citations