Regulation of E2F through ubiquitin–proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Mechanism of active transcriptional repression by the retinoblastoma protein

1995 • 494 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

1994 • 393 citations

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1995 • 361 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

Selective protein degradation: A journey's end within the proteasome

1995 • 259 citations

Oncogenic capacity of the E2F1 gene.

1994 • 254 citations

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.

1995 • 248 citations

In Vivo Association of E2F and DP Family Proteins

1995 • 246 citations

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.

1996 • 228 citations

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

1996 • 207 citations

Multiple members of the E2F transcription factor family are the products of oncogenes.

1995 • 197 citations

Deregulated Expression of E2F-1 Induces S-Phase Entry and Leads to Apoptosis

1994 • 160 citations

Cellular Proteolysis An Overview

1992 • 75 citations

mUBC9, a Novel Adenovirus E1A-interacting Protein That Complements a Yeast Cell Cycle Defect

1996 • 69 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein

1994 • 59 citations