mUBC9, a Novel Adenovirus E1A-interacting Protein That Complements a Yeast Cell Cycle Defect

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites

1988 • 2,903 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Transcription activation by the adenovirus E1a protein

1989 • 667 citations

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

1995 • 578 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

1995 • 534 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

1995 • 492 citations

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

1993 • 476 citations

Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA

1980 • 463 citations

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

1984 • 458 citations

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

1990 • 391 citations

Cloning of an Intrinsic Human TFIID Subunit That Interacts with Multiple Transcriptional Activators

1995 • 385 citations

Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor

1991 • 381 citations

Association of adenovirus early-region 1A proteins with cellular polypeptides.

1986 • 368 citations

Adenovirus E1a proteins repress transcription from the SV40 early promoter

1985 • 366 citations

Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation.

1995 • 361 citations

Degradation of nuclear oncoproteins by the ubiquitin system in vitro.

1991 • 345 citations

The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.

1993 • 341 citations

A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis.

1993 • 304 citations

p34^Cdc28-Mediated Control of Cln3 Cyclin Degradation

1995 • 293 citations

Functional domains of adenovirus type 5 E1a proteins

1987 • 283 citations

Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains

1994 • 256 citations

Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth

1993 • 254 citations

Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins

1991 • 244 citations

Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IID.

1991 • 242 citations

Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes.

1986 • 231 citations

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides

1985 • 227 citations

Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets

1990 • 221 citations

Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.

1995 • 213 citations

RNA-RNA interactions in the spliceosome: Unraveling the ties that bind

1994 • 208 citations

Transcriptional and Transforming Activities of the Adenovirus E1A Proteins

1991 • 187 citations

Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes.

1996 • 163 citations

Degradation of c-Fos by the 26S Proteasome Is Accelerated by c-Jun and Multiple Protein Kinases

1995 • 140 citations

Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFβ-treated cells

1996 • 135 citations

The Schizosaccharomyces Pombe Hus5 gene encodes a ubiquitin conjugating enzyme required for normal mitosis

1995 • 130 citations

E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products.

1991 • 102 citations

Transcriptional Activation by the Adenovirus Larger E1a Product is Mediated by Members of the Cellular Transcription Factor ATF Family Which Can Directly Associate with E1a

1993 • 99 citations

Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin A

1992 • 96 citations

BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation.

1995 • 90 citations

Subregions of the Adenovirus E1A Transactivation Domain Target Multiple Components of the TFIID Complex

1995 • 74 citations

An adenovirus E1A protein domain activates transcription in vivo and in vitro in the absence of protein synthesis

1988 • 69 citations

Rapid intracellular turnover of adenovirus 5 early region 1A proteins

1984 • 62 citations

Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle

1996 • 38 citations

Rapid turnover of adenovirus E1A is determined through a co-translational mechanism that requires an aminoterminal domain.

1988 • 24 citations

Stabilities and interrelations of multiple species of human adenovirus type 5 early region 1 proteins in infected and transformed cells

1985 • 20 citations

A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene.

1995 • 16 citations

The degradation sequence of adenovirus E1A consists of the amino-terminal tetrapeptide Met-Arg-His-Ile.

1990 • 8 citations