Nitric Oxide in Endothelial Dysfunction and Vascular Remodeling: Clinical Correlates and Experimental Links

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

1995 • 2,075 citations

The Emerging Concept of Vascular Remodeling

1994 • 1,563 citations

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

1997 • 1,162 citations

Reductions in Arterial Diameter Produced by Chronic Decreases in Blood Flow Are Endothelium-Dependent

1986 • 1,106 citations

Beneficial Effects of Cholesterol-Lowering Therapy on the Coronary Endothelium in Patients with Coronary Artery Disease

1996 • 1,066 citations

Angiotensin-Converting Enzyme Inhibition With Quinapril Improves Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

1996 • 1,065 citations

Cellular and molecular mechanisms of endothelial cell dysfunction.

1997 • 1,064 citations

Elevated blood pressures in mice lacking endothelial nitric oxide synthase

1996 • 888 citations

Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.

1994 • 858 citations

Adaptive regulation of wall shear stress to flow change in the canine carotid artery

1980 • 812 citations

Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.

1998 • 799 citations

Small artery structure in hypertension. Dual processes of remodeling and growth.

1993 • 645 citations

A smoking–dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene

1996 • 571 citations

Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension

1998 • 530 citations

A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese

1998 • 407 citations

Role of NO in Flow-Induced Remodeling of the Rabbit Common Carotid Artery

1996 • 369 citations

Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice.

1998 • 339 citations

Defective <scp>l</scp> -Arginine–Nitric Oxide Pathway in Offspring of Essential Hypertensive Patients

1996 • 312 citations

Genetic Contribution of the Endothelial Constitutive Nitric Oxide Synthase Gene to Plasma Nitric Oxide Levels

1997 • 294 citations

Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction

1999 • 290 citations

Coronary Hemodynamics in Endothelial NO Synthase Knockout Mice

1998 • 265 citations

Chronic Inhibition of Nitric Oxide Synthesis Causes Coronary Microvascular Remodeling in Rats

1995 • 208 citations

Nitric oxide synthase gene polymorphisms, blood pressure and aortic stiffness in normotensive and hypertensive subjects

1998 • 180 citations

Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension

1995 • 160 citations

Endothelial Function and Common Carotid Artery Wall Thickening in Patients With Essential Hypertension

1998 • 142 citations

Flow-induced arterial enlargement is inhibited by suppression of nitric oxide synthase activity in vivo

1997 • 127 citations

Chronic Blockade of NO Synthase Activity Induces a Proinflammatory Phenotype in the Arterial Wall

1998 • 115 citations

Noninvasive Detection of an Increased Vascular Mass in Untreated Hypertensive Patients

1994 • 94 citations

Regional Remodeling of Atherosclerotic Arteries: A Major Determinant of Clinical Manifestations of Disease

1997 • 83 citations

Limb reduction defects in endothelial nitric oxide synthase-deficient mice

1998 • 72 citations

Lack of linkage between the endothelial nitric oxide synthase gene and hypertension.

1996 • 36 citations

Absence of Linkage for ‘Endothelial’ Nitric Oxide Synthase Locus to Blood Pressure in Dahl Rats

1997 • 18 citations