Platelet growth factors: potential impact on transfusion medicine

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

Thrombopoietin: the primary regulator of platelet production [see comments]

1995 • 691 citations

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

1996 • 589 citations

Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation

1998 • 469 citations

Extensive Amplification and Self-Renewal of Human Primitive Hematopoietic Stem Cells From Cord Blood

1997 • 464 citations

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.

1996 • 445 citations

A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors

1990 • 404 citations

Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine

1997 • 400 citations

Safety of stringent prophylactic platelet transfusion policy for patients with acute leukaemia

1991 • 341 citations

A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy

1996 • 299 citations

Effects of Polyethylene Glycol–Conjugated Recombinant Human Megakaryocyte Growth and Development Factor on Platelet Counts after Chemotherapy for Lung Cancer

1997 • 298 citations

Low levels of erythroid and myeloid progenitors in thrombopoietin-and c- mpl-deficient mice

1996 • 287 citations

Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer

1996 • 226 citations

Stimulation of Megakaryocyte and Platelet Production by a Single Dose of Recombinant Human Thrombopoietin in Patients with Cancer

1997 • 226 citations

Thrombocytopenia: Mechanisms and Management of Defects in Platelet Production

1978 • 222 citations

A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy

1996 • 216 citations

Collection and transfusion of blood and blood components in the United States, 1992

1995 • 207 citations

Platelet transfusions: the 20,000/microL trigger [see comments]

1993 • 206 citations

Randomized, Blinded, Placebo-Controlled Phase I Trial of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor With Filgrastim After Dose-Intensive Chemotherapy in Patients With Advanced Cancer

1997 • 206 citations

Megakaryocyte growth and development factor ameliorates carboplatin- induced thrombocytopenia in mice

1995 • 206 citations

Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates

1995 • 204 citations

Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia.

1996 • 192 citations

Platelet Transfusion Therapy

1987 • 191 citations

Demonstration and Some Properties of Human Thrombopoietin in Thrombocythaemic Sera

1958 • 187 citations

Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice

1993 • 162 citations

Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates

1996 • 159 citations

Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors

1995 • 157 citations

Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates

1996 • 151 citations

Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation

1996 • 142 citations

Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: acceleration of recovery of peripheral blood neutrophils and platelets

1993 • 139 citations

Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin

1994 • 93 citations

Platelet Utilization in a University Hospital

1988 • 77 citations

Bleeding Due to Thrombocytopenia in Acute Leukemias and Reevaluation of the Prophylactic Platelet Transfusion Policy

1986 • 74 citations

Incidence of Hemorrhagic Complications in Patients With Cancer

1978 • 70 citations

Multilineage mobilization of peripheral blood progenitor cells in humans following administration of PEG‐rHuMGDF

1997 • 68 citations

Incidence of hemorrhagic complications in patients with cancer

1978 • 60 citations

Preclinical biology of interleukin 11: A multifunctional hematopoietic cytokine with potent thrombopoietic activity

1995 • 60 citations

Prevention of Thrombocytopenia and Neutropenia in a Nonhuman Primate Model of Marrow Suppressive Chemotherapy by Combining Pegylated Recombinant Human Megakaryocyte Growth and Development Factor and Recombinant Human Granulocyte Colony-Stimulating Factor

1997 • 50 citations

Thrombopoietin: Biology and Clinical Applications

1996 • 35 citations

The use of PEG‐rHuMGDF in platelet apheresis

1998 • 19 citations

Megakaryocyte Biology

1997 • 11 citations

The Role of Other Hemopoietic Growth Factors and the Marrow Microenvironment in Megakaryocytopoiesis

1997 • 7 citations