ATF3 Inhibits Doxorubicin-induced Apoptosis in Cardiac Myocytes: A Novel Cardioprotective Role of ATF3

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

Apoptosis

1998 • 806 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

Anthracycline cardiomyopathy monitored by morphologic changes.

1978 • 589 citations

“Stress-Responsive” Mitogen-Activated Protein Kinases (c-Jun N-Terminal Kinases and p38 Mitogen-Activated Protein Kinases) in the Myocardium

1998 • 510 citations

Inhibition of Extracellular Signal–Regulated Kinase Enhances Ischemia/Reoxygenation–Induced Apoptosis in Cultured Cardiac Myocytes and Exaggerates Reperfusion Injury in Isolated Perfused Heart

2000 • 419 citations

Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney

1997 • 374 citations

Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses

1999 • 340 citations

p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes.

1997 • 310 citations

ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms.

1994 • 240 citations

Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.

1985 • 227 citations

ATF3 Gene

1996 • 222 citations

Glycoprotein 130 Regulates Cardiac Myocyte Survival in Doxorubicin-Induced Apoptosis Through Phosphatidylinositol 3-Kinase/Akt Phosphorylation and Bcl-xL/Caspase-3 Interaction

2001 • 217 citations

Suppression by Metallothionein of Doxorubicin-induced Cardiomyocyte Apoptosis through Inhibition of p38 Mitogen-activated Protein Kinases

2000 • 209 citations

Daunorubicin-Induced Apoptosis in Rat Cardiac Myocytes Is Inhibited by Dexrazoxane

1999 • 204 citations

Stress-Activated Protein Kinases in Cardiovascular Disease

1996 • 204 citations

Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration.

1992 • 188 citations

Mechanism of Doxorubicin-Induced Inhibition of Sarcoplasmic Reticulum Ca ²⁺ -ATPase Gene Transcription

2000 • 178 citations

Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element

2000 • 176 citations

MAPK Superfamily Plays an Important Role in Daunomycin-Induced Apoptosis of Cardiac Myocytes

1999 • 163 citations

Doxorubicin Induces Apoptosis and CD95 Gene Expression in Human Primary Endothelial Cells through a p53-dependent Mechanism

2002 • 156 citations

gadd153/Chop10, a Potential Target Gene of the Transcriptional Repressor ATF3

1997 • 155 citations

Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells

1999 • 150 citations

Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver.

1991 • 139 citations

MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes

1999 • 134 citations

Cytoprotection by Jun Kinase During Nitric Oxide–Induced Cardiac Myocyte Apoptosis

2001 • 123 citations

Role of Mitogen-Activated Protein Kinases in Ischemia and Reperfusion Injury

2000 • 121 citations

Doxorubicin-induced Apoptosis in Spontaneously Hypertensive Rats: Differential Effects in Heart, Kidney and Intestine, and Inhibition by ICRF-187

1996 • 118 citations

Cyclin A/cdk2 Activation Is Involved in Hypoxia-Induced Apoptosis in Cardiomyocytes

2001 • 114 citations

Insulin-Like Growth Factor-1 Induces Mdm2 and Down-Regulates p53, Attenuating the Myocyte Renin-Angiotensin System and Stretch-Mediated Apoptosis

1999 • 113 citations

Suppression of Stress Kinase JNK Is Involved in HSP72-mediated Protection of Myogenic Cells from Transient Energy Deprivation

2000 • 107 citations

Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis

1996 • 104 citations

Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent‐induced apoptosis

2001 • 103 citations

Transgenic Mice with Cardiac-Specific Expression of Activating Transcription Factor 3, a Stress-Inducible Gene, Have Conduction Abnormalities and Contractile Dysfunction

2001 • 100 citations

Transcriptional Autorepression of the Stress-inducible GeneATF3

2000 • 99 citations

Apoptosis in Rat Cardiac Myocytes Induced by Fas Ligand: Priming for Fas-mediated Apoptosis with Doxorubicin

2000 • 85 citations

Essential roles for G₁cyclin-dependent kinase activity in development of cardiomyocyte hypertrophy

1998 • 67 citations

AP-1 Repressor Protein JDP-2: Inhibition of UV-Mediated Apoptosis through p53 Down-Regulation

2001 • 59 citations

Thermal preconditioning protects rat cardiac muscle cells from doxorubicin-induced apoptosis

1999 • 59 citations

Repression of TNF-α-Induced E-Selectin Expression by PPAR Activators: Involvement of Transcriptional Repressor LRF-1/ATF3

2000 • 57 citations

Distribution of mRNAs for natriuretic peptides in RV hypertrophy after pulmonary arterial banding

1995 • 45 citations

MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes

2000 • 18 citations