Doxorubicin-induced Apoptosis in Endothelial Cells and Cardiomyocytes Is Ameliorated by Nitrone Spin Traps and Ebselen

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Methods of Enzymatic Analysis

1975 • 20,446 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

A fluorometric method for determination of oxidized and reduced glutathione in tissues

1976 • 4,013 citations

Caspases: killer proteases

1997 • 2,440 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Doxorubicin-Induced Cardiomyopathy

1998 • 1,774 citations

Apoptosis in Myocytes in End-Stage Heart Failure

1996 • 1,446 citations

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Regulation of hepatic glutathione synthesis: current concepts and controversies

1999 • 858 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1997 • 801 citations

Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.

1975 • 729 citations

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

1997 • 663 citations

Death and the cell

1986 • 616 citations

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

1986 • 608 citations

Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin

1977 • 545 citations

Superoxide sensitivity of the Escherichia coli aconitase.

1991 • 499 citations

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.

1991 • 406 citations

Oxidative Damage of Cardiomyocytes Is Limited by Extracellular Regulated Kinases 1/2-mediated Induction of Cyclooxygenase-2

1999 • 382 citations

The role of iron in the activation-inactivation of aconitase.

1983 • 379 citations

Evidence for free radical formation during the oxidation of 2′-7′-dichlorofluorescin to the fluorescent dye 2′-7′-dichlorofluorescein by horseradish peroxidase:Possible implications for oxidative stress measurements

1999 • 377 citations

Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation.

1977 • 365 citations

Endothelial Nitric Oxide Synthase-Dependent Superoxide Generation from Adriamycin

1997 • 360 citations

Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody

1996 • 354 citations

Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs

1980 • 317 citations

Mitochondrial Aconitase Is a Source of Hydroxyl Radical

2000 • 306 citations

Early and delayed clinical cardiotoxicity of doxorubicin

1985 • 300 citations

Characterization of Sulfur-centered Radical Intermediates Formed during the Oxidation of Thiols and Sulfite by Peroxynitrite

1996 • 222 citations

Phenoxyl Free Radical Formation during the Oxidation of the Fluorescent Dye 2′,7′-Dichlorofluorescein by Horseradish Peroxidase

1999 • 220 citations

Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor

2000 • 211 citations

Role of iron in anthracycline cardiotoxicity: new tunes for an old song?

1999 • 209 citations

Daunorubicin-Induced Apoptosis in Rat Cardiac Myocytes Is Inhibited by Dexrazoxane

1999 • 204 citations

Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells

1993 • 194 citations

A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro.

1995 • 191 citations

Non-oxidative Loss of Glutathione in Apoptosis via GSH Extrusion

1995 • 190 citations

Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis

1995 • 189 citations

Cell Culture Techniques in Heart and Vessel Research

1990 • 179 citations

Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage–induced apoptosis

1999 • 176 citations

MAPK Superfamily Plays an Important Role in Daunomycin-Induced Apoptosis of Cardiac Myocytes

1999 • 163 citations

Manganese Superoxide Dismutase Protects Mitochondrial Complex I against Adriamycin-Induced Cardiomyopathy in Transgenic Mice

1999 • 141 citations

N-t-Butyl Hydroxylamine, a Hydrolysis Product of α-Phenyl-N-t-butyl Nitrone, Is More Potent in Delaying Senescence in Human Lung Fibroblasts

2000 • 139 citations

Tumor necrosis factor-α and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells

1999 • 137 citations

Pulse radiolysis studies of antitumor quinones: Radical lifetimes, reactivity with oxygen, and one-electron reduction potentials

1981 • 124 citations

Cell-Permeable Superoxide Dismutase and Glutathione Peroxidase Mimetics Afford Superior Protection against Doxorubicin-Induced Cardiotoxicity: The Role of Reactive Oxygen and Nitrogen Intermediates

1999 • 121 citations

Interaction of α‐Phenyl‐N‐tert‐Butyl Nitrone and Alternative Electron Acceptors with Complex I Indicates a Substrate Reduction Site Upstream from the Rotenone Binding Site

1998 • 118 citations

Hydrogen Peroxide Dose Dependent Induction of Cell Death or Hypertrophy in Cardiomyocytes

2000 • 117 citations

Redox-sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture

1999 • 111 citations

Ebselen Induces Apoptosis in HepG2 Cells through Rapid Depletion of Intracellular Thiols

2000 • 103 citations

G2 block induced by DNA crosslinking agents and its possible consequences

1988 • 96 citations

Pharmacologic Properties of PhenylN-tert-Butylnitrone

1999 • 82 citations

Inhibition of glutathione synthesis increases the toxicity of oxidized low-density lipoprotein to human monocytes and macrophages

1993 • 71 citations

Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells

1999 • 62 citations

Adult Ventricular Rat Heart Muscle Cells

1990 • 51 citations

Subcellular Distribution of Two Spin Trapping Agents in Rat Heart: Possible Explanation for Their Different Protective Effects Against Doxorubicin-Induced Cardiotoxicity

1992 • 51 citations

The mechanism of cardioprotection by S‐nitrosoglutathione monoethyl ester in rat isolated heart during cardioplegic ischaemic arrest

1996 • 41 citations

Involvement of Phosphorylation in Doxorubicin-Mediated Myofibril Degeneration

1997 • 32 citations

Protective Effects of Spin-Trapping Agents on Adriamycin-Induced Cardiotoxicity in Isolated Rat Atria

1991 • 30 citations

Caspase-3 activation during apoptosis caused by glutathione–doxorubicin conjugate

1999 • 29 citations

Cell culture techniques in heart and vessel research

1991 • 16 citations

Spin trapping chemistry of sodium 2-sulfonatophenyl -butyl nitrone . a negatively charged water-soluble spin trap

1979 • 11 citations