E-cadherin downregulation in cancer: fuel on the fire?

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

Origins of Cell Polarity

1996 • 1,024 citations

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

1994 • 920 citations

Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human Cancers

1998 • 846 citations

MOLECULAR AND FUNCTIONAL ANALYSIS OF CADHERIN-BASED ADHERENS JUNCTIONS

1997 • 800 citations

Structural basis of calcium-induced E-cadherin rigidification and dimerization

1996 • 688 citations

Signal transduction through beta-catenin and specification of cell fate during embryogenesis.

1996 • 663 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

Mutations of the human E-cadherin (CDH1) gene

1998 • 598 citations

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

1995 • 498 citations

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

1996 • 466 citations

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways

1998 • 421 citations

The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules.

1994 • 398 citations

Cadherins and catenins in development

1996 • 344 citations

E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis

1997 • 341 citations

Identification of germ-line E-cadherin mutations in gastric cancer families of European origin.

1998 • 330 citations

Lateral dimerization is required for the homophilic binding activity of C-cadherin.

1996 • 307 citations

The structural and functional analysis of cadherin calcium-dependent cell adhesion molecules

1993 • 291 citations

E-cadherin mediated adhesion system in cancer cells

1996 • 281 citations

THE INTERACTIONS OF APC, E-CADHERIN AND β-CATENIN IN TUMOUR DEVELOPMENT AND PROGRESSION

1997 • 171 citations

Expression and Functional Role of E- and P-Cadherins in Mouse Mammary Ductal Morphogenesis and Growth

1995 • 165 citations

RB and c-Myc Activate Expression of the E-Cadherin Gene in Epithelial Cells through Interaction with Transcription Factor AP-2

1998 • 161 citations

Adhesive But Not Lateral E-cadherin Complexes Require Calcium and Catenins for Their Formation

1998 • 154 citations

Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma.

1998 • 150 citations

Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene.

1994 • 146 citations

Nonmalignant epithelial cells, potentially invasive in human endometriosis, lack the tumor suppressor molecule E-cadherin.

1997 • 139 citations

Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line

1995 • 138 citations

E‐Cadherin Gene Mutations in Signet Ring Cell Carcinoma of the Stomach

1996 • 135 citations

Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines.

1998 • 135 citations

Dysregulation of the E-Cadherin/Catenin Complex by Irreversible Mutations in Human Carcinomas

1998 • 102 citations

Role of E-cadherin in the response of tumor cell aggregates to lymphatic, venous and arterial flow: measurement of cell-cell adhesion strength

1995 • 84 citations

Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract.

1996 • 83 citations

Cancer metastasis: negative regulation by an invasion-suppressor complex.

1995 • 61 citations

Enlarged cell-associated proteoglycans abolish E-cadherin functionality in invasive tumor cells.

1994 • 57 citations

Modulation of Epithelial Cell Adhesion in Gastrointestinal Homeostasis

1998 • 42 citations

Effects of PAX2 expression in a human fetal kidney (HEK293) cell line

1998 • 41 citations