Dendritic Cells Prime Natural Killer Cells by trans-Presenting Interleukin 15

Dendritic cells and the control of immunity

1998 • 14,345 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

Decoding the Patterns of Self and Nonself by the Innate Immune System

2002 • 2,096 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

„Natural”︁ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype

1975 • 1,743 citations

In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

2002 • 1,734 citations

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

2004 • 1,657 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity

1975 • 1,308 citations

Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming

2004 • 1,284 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Licensing of natural killer cells by host major histocompatibility complex class I molecules

2005 • 1,256 citations

Human NK Cell Education by Inhibitory Receptors for MHC Class I

2006 • 1,101 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo

1999 • 1,066 citations

Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

2001 • 1,036 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells

2002 • 1,027 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells

2002 • 877 citations

T cell– and B cell–independent adaptive immunity mediated by natural killer cells

2006 • 869 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion

2005 • 780 citations

GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large

2006 • 775 citations

Enhanced NK cell activity in mice injected with interferon and interferon inducers

1978 • 735 citations

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

2004 • 719 citations

Contact-dependent Stimulation and Inhibition of Dendritic Cells by Natural Killer Cells

2002 • 704 citations

Natural killer cells and dendritic cells: rendezvous in abused tissues

2002 • 674 citations

The Role of the NKG2D Immunoreceptor in Immune Cell Activation and Natural Killing

2002 • 634 citations

Coordinated and Distinct Roles for IFN-αβ, IL-12, and IL-15 Regulation of NK Cell Responses to Viral Infection

2002 • 594 citations

Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs

2004 • 563 citations

Molecular Cloning of NKp46: A Novel Member of the Immunoglobulin Superfamily Involved in Triggering of Natural Cytotoxicity

1998 • 562 citations

A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules

2005 • 560 citations

Natural killer cells as an initial defense against pathogens

2006 • 451 citations

Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease

2003 • 449 citations

IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation

2001 • 445 citations

CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: Induction of cytokine release and cytotoxicity against tumors and dendritic cells

2004 • 443 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy

2001 • 441 citations

In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells

2002 • 438 citations

NK cell and DC interactions

2003 • 437 citations

Evidence for discrete stages of human natural killer cell differentiation in vivo

2006 • 415 citations

A Human CD34(+) Subset Resides in Lymph Nodes and Differentiates into CD56brightNatural Killer Cells

2005 • 369 citations

Functional interactions between dendritic cells and NK cells during viral infection

2002 • 362 citations

Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype Cd8+ T Cells

2001 • 362 citations

Dendritic Cell Responses to Early Murine Cytomegalovirus Infection

2003 • 349 citations

Dendritic Cells Maximize the Memory CD8 T Cell Response to Infection

2005 • 320 citations

Early gamma interferon production by natural killer cells is important in defense against murine listeriosis

1991 • 316 citations

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.

1994 • 305 citations

Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction

1978 • 296 citations

TLR7/8-Mediated Activation of Human NK Cells Results in Accessory Cell-Dependent IFN-γ Production

2005 • 296 citations

Natural killer cell behavior in lymph nodes revealed by static and real-time imaging

2006 • 290 citations

Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity

2005 • 276 citations

Critical Role of MHC Class I-Related Chain A and B Expression on IFN-α-Stimulated Dendritic Cells in NK Cell Activation: Impairment in Chronic Hepatitis C Virus Infection

2003 • 258 citations

The effect of the Cmv-1 resistance gene, which is linked to the natural killer cell gene complex, is mediated by natural killer cells.

1992 • 242 citations

In Vivo Survival and Homeostatic Proliferation of Natural Killer Cells

2003 • 238 citations

APC-Independent Activation of NK Cells by the Toll-Like Receptor 3 Agonist Double-Stranded RNA

2004 • 236 citations

Triggering of Natural Killer Cells by the Costimulatory Molecule CD80 (B7-1)

1996 • 233 citations

Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells

2005 • 231 citations

Cutting Edge: Toll-Like Receptor Signaling in Macrophages Induces Ligands for the NKG2D Receptor

2004 • 203 citations

Cutting Edge: Murine Dendritic Cells Require IL-15Rα to Prime NK Cells

2004 • 197 citations

Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. II. "Specificities" of the natural killer cells.

1979 • 182 citations

Recognition of autologous dendritic cells by human NK cells

1999 • 177 citations

T Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation

2001 • 174 citations

Role of macrophages in the augementation of mouse natural killer cell activity by poly I:C and interferon.

1979 • 170 citations

Autocrine/Paracrine IL-15 That Is Required for Type I IFN-Mediated Dendritic Cell Expression of MHC Class I-Related Chain A and B Is Impaired in Hepatitis C Virus Infection

2003 • 167 citations

Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum

2005 • 163 citations

Role of Macrophages in the Augmentation of Mouse Natural Killer Cell Activity by Poly I:C and Interferon

1979 • 121 citations

In Vivo Ablation of CD11c-Positive Dendritic Cells Increases Susceptibility to Herpes Simplex Virus Type 1 Infection and Diminishes NK and T-Cell Responses

2006 • 119 citations

Dendritic cells that have interacted with antigen are targets for natural killer cells.

1985 • 112 citations

Suppression of tumor formation in lymph nodes by L-selectin–mediated natural killer cell recruitment

2005 • 98 citations

IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis

2002 • 85 citations

Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo

2006 • 78 citations

IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis

2002 • 72 citations

Abrogation of resistance to foreign bone marrow grafts by carrageenans. I. Studies with the anti-macrophage agent seakem carrageenan.

1977 • 38 citations

Antibody to mouse interferon alpha/beta abrogates resistance to the multiplication of Friend erythroleukemia cells in the livers of allogeneic mice.

1988 • 35 citations

CD40 Ligation In Vivo Induces Bystander Proliferation of Memory Phenotype CD8 T Cells

2004 • 28 citations

Abrogation of Resistance to Foreign Bone Marrow Grafts by Carrageenans

1977 • 22 citations