Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs

Biology of Natural Killer Cells

1989 • 2,970 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset

2001 • 1,364 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo

1999 • 1,066 citations

Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells

2002 • 1,027 citations

Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells

2002 • 986 citations

IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells

2002 • 877 citations

Regulation of Dendritic Cell Migration to the Draining Lymph Node

2003 • 863 citations

CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity

2003 • 820 citations

Contact-dependent Stimulation and Inhibition of Dendritic Cells by Natural Killer Cells

2002 • 704 citations

Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection

2001 • 622 citations

Coordinated and Distinct Roles for IFN-αβ, IL-12, and IL-15 Regulation of NK Cell Responses to Viral Infection

2002 • 594 citations

The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic

2004 • 561 citations

Inducible IL-2 production by dendritic cells revealed by global gene expression analysis

2001 • 517 citations

Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire

2001 • 515 citations

CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells

2001 • 449 citations

IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation

2001 • 445 citations

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones.

1992 • 430 citations

A Novel Lysosome-Associated Membrane Glycoprotein, DC-LAMP, Induced upon DC Maturation, Is Transiently Expressed in MHC Class II Compartment

1998 • 402 citations

Functional interactions between dendritic cells and NK cells during viral infection

2002 • 362 citations

Dendritic Cells Mediate NK Cell Help for Th1 and CTL Responses: Two-Signal Requirement for the Induction of NK Cell Helper Function

2003 • 347 citations

NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs

2004 • 317 citations

A direct role for IFN-gamma in regulation of Th1 cell development.

1996 • 304 citations

NK Cell Compartments and Their Activation by Dendritic Cells

2004 • 296 citations

Critical Role of MHC Class I-Related Chain A and B Expression on IFN-α-Stimulated Dendritic Cells in NK Cell Activation: Impairment in Chronic Hepatitis C Virus Infection

2003 • 258 citations

Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient Mice

2003 • 241 citations

The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells

2003 • 203 citations

A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation

2004 • 198 citations

Cutting Edge: Murine Dendritic Cells Require IL-15Rα to Prime NK Cells

2004 • 197 citations

The small subset of CD56^brightCD16^– natural killer cells is selectively responsible for both cell proliferation and interferon‐γ production upon interaction with dendritic cells

2004 • 195 citations

Epstein-Barr Nuclear Antigen 1-Specific CD4+ Th1 Cells Kill Burkitt’s Lymphoma Cells

2002 • 168 citations

Autocrine/Paracrine IL-15 That Is Required for Type I IFN-Mediated Dendritic Cell Expression of MHC Class I-Related Chain A and B Is Impaired in Hepatitis C Virus Infection

2003 • 167 citations

Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: a role for IL-15 in attraction of T cells.

1997 • 167 citations

Enhancement of Human Cord Blood CD34+ Cell-Derived NK Cell Cytotoxicity by Dendritic Cells

2001 • 145 citations

Investigation of human spleen dendritic cell phenotype and distribution reveals evidence of in vivo activation in a subset of organ donors

2001 • 87 citations

Preventing NK Cell Activation by Donor Dendritic Cells Enhances Allospecific CD4 T Cell Priming and Promotes Th Type 2 Responses to Transplantation Antigens

2002 • 50 citations