ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

2000 • 6,302 citations

FACS-optimized mutants of the green fluorescent protein (GFP)

1996 • 2,539 citations

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

2004 • 2,135 citations

Autophagy Defends Cells Against Invading Group A Streptococcus

2004 • 1,042 citations

Escape of Intracellular Shigella from Autophagy

2004 • 798 citations

Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin.

1994 • 512 citations

ATP-Induced Killing of Mycobacteria by Human Macrophages Is Mediated by Purinergic P2Z(P2X7) Receptors

1997 • 392 citations

Effects of cytokines on mycobacterial phagosome maturation

1998 • 349 citations

Lysosomal killing ofMycobacteriummediated by ubiquitin-derived peptides is enhanced by autophagy

2007 • 309 citations

Staphylococcus aureus Subvert Autophagy for Induction of Caspase-independent Host Cell Death

2006 • 262 citations

Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles

1997 • 234 citations

ATP-Mediated Killing of Intracellular Mycobacteria by Macrophages Is a P2X7-Dependent Process Inducing Bacterial Death by Phagosome-Lysosome Fusion

2001 • 233 citations

Listeria monocytogenesEvades Killing by Autophagy During Colonization of Host Cells

2007 • 232 citations

Autophagy as an immune defense mechanism

2006 • 197 citations

A Polymorphism in the P2X₇Gene Increases Susceptibility to Extrapulmonary Tuberculosis

2006 • 195 citations

The effect of wortmannin on the localisation of lysosomal type I integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocytic pathway

1996 • 175 citations

Assessment of Immunity to Mycobacterial Infection with Luciferase Reporter Constructs

1999 • 174 citations

A Thr357 to Ser Polymorphism in Homozygous and Compound Heterozygous Subjects Causes Absent or Reduced P2X7 Function and Impairs ATP-induced Mycobacterial Killing by Macrophages

2005 • 166 citations

ATP Stimulates Human Macrophages to Kill Intracellular Virulent Mycobacterium tuberculosis Via Calcium-Dependent Phagosome-Lysosome Fusion

2001 • 156 citations

P2X7 purinergic receptors and extracellular ATP mediate apoptosis of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the intracellular bacterial viability

2006 • 85 citations

ATP-Mediated Killing ofMycobacterium bovisBacille Calmette-Guérin Within Human Macrophages Is Calcium Dependent and Associated with the Acidification of Mycobacteria-Containing Phagosomes

2001 • 76 citations

Point mutations confer loss of ATP‐induced human P2X₇ receptor function

2002 • 53 citations

Hepatic autophagy and intracellular ATP a morphometric study

1988 • 51 citations

The P2X7 purinergic receptor on bovine macrophages mediates mycobacterial death

2001 • 42 citations

Characterisation of the P2X7 receptor-mediated signalling pathway associated with rapid killing of intracellular mycobacteria within human macrophages

2001 • 4 citations