A Polymorphism in the P2X₇Gene Increases Susceptibility to Extrapulmonary Tuberculosis

Immunology of Tuberculosis

2001 • 2,111 citations

Variations in theNRAMP1Gene and Susceptibility to Tuberculosis in West Africans

1998 • 736 citations

Priorities for the Treatment of Latent Tuberculosis Infection in the United States

2004 • 636 citations

The Permeabilizing ATP Receptor, P2X7

1997 • 486 citations

ATP-Induced Killing of Mycobacteria by Human Macrophages Is Mediated by Purinergic P2Z(P2X7) Receptors

1997 • 392 citations

A Glu-496 to Ala Polymorphism Leads to Loss of Function of the Human P2X7 Receptor

2001 • 311 citations

Influence of Polymorphism in the Genes for the Interleukin (IL)-1 Receptor Antagonist and IL-1β on Tuberculosis

1999 • 288 citations

P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death

1999 • 276 citations

Ethnic‐Specific Genetic Associations with Pulmonary Tuberculosis

2002 • 269 citations

ATP-Mediated Killing of Intracellular Mycobacteria by Macrophages Is a P2X7-Dependent Process Inducing Bacterial Death by Phagosome-Lysosome Fusion

2001 • 233 citations

Susceptibility to mycobacterial infections: the importance of host genetics

2003 • 233 citations

SAPK/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor

2000 • 205 citations

Confrontation between Intracellular Bacteria and the Immune System

1998 • 186 citations

Mannose-Binding Protein B Allele Confers Protection against Tuberculous Meningitis

1999 • 166 citations

An Ile-568 to Asn Polymorphism Prevents Normal Trafficking and Function of the Human P2X7 Receptor

2003 • 165 citations

ATP-Induced Killing of Virulent Mycobacterium tuberculosis Within Human Macrophages Requires Phospholipase D

2000 • 163 citations

Stress-activated Protein Kinase/JNK Activation and Apoptotic Induction by the Macrophage P2X7 Nucleotide Receptor

2000 • 163 citations

ATP Stimulates Human Macrophages to Kill Intracellular Virulent Mycobacterium tuberculosis Via Calcium-Dependent Phagosome-Lysosome Fusion

2001 • 156 citations

Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor

2006 • 154 citations

A novel pathway for the activation of phospholipase D by P2z purinergic receptors in BAC1.2F5 macrophages.

1992 • 154 citations

Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans

1998 • 146 citations

Glu496 to Ala Polymorphism in the P2X7 Receptor Impairs ATP-Induced IL-1β Release from Human Monocytes

2004 • 144 citations

An Arg307 to Gln Polymorphism within the ATP-binding Site Causes Loss of Function of the Human P2X7 Receptor

2004 • 141 citations

Association of a Polymorphism in the P2X₇Gene with Tuberculosis in a Gambian Population

2002 • 138 citations

Evidence that genetic susceptibility to Mycobacterium tuberculosis in a brazilian population is under oligogenic control: Linkage study of the candidate genes NRAMP1 and TBFA

1997 • 133 citations

Tuberculosis Diagnosed at Death in the United States

1991 • 132 citations

A Loss-of-Function Polymorphism in the Human P2X7 Receptor Abolishes ATP-Mediated Killing of Mycobacteria

2003 • 123 citations

Cutting Edge: Purinergic Signaling Regulates Radical-Mediated Bacterial Killing Mechanisms in Macrophages Through a P2X7-Independent Mechanism

1999 • 121 citations

Association of functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in India

1999 • 108 citations

Partial agonists and antagonists reveal a second permeability state of human lymphocyte P2Z/P2X₇channel

1998 • 103 citations

P2X7 receptor polymorphism impairs extracellular adenosine 5′-triphosphate-induced interleukin-18 release from human monocytes

2004 • 98 citations

Incidence of Tuberculosis among a Cohort of Tuberculin-Positive Refugees in Australia

2000 • 77 citations

ATP-Mediated Killing ofMycobacterium bovisBacille Calmette-Guérin Within Human Macrophages Is Calcium Dependent and Associated with the Acidification of Mycobacteria-Containing Phagosomes

2001 • 76 citations

NRAMP1 genetic polymorphisms as a risk factor of tuberculous pleurisy.

2003 • 63 citations

Gene Dosage Determines the Negative Effects of Polymorphic Alleles of the P2X₇Receptor on Adenosine Triphosphate–Mediated Killing of Mycobacteria by Human Macrophages

2005 • 62 citations

A 5′ intronic splice site polymorphism leads to a null allele of the P2X₇ gene in 1–2% of the Caucasian population

2005 • 59 citations

Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors

2002 • 57 citations

Human Epidermal and Monocyte-Derived Langerhans Cells Express Functional P2X7 Receptors

2005 • 48 citations

Acute Effects of Parainfluenza Virus on Epithelial Electrolyte Transport

2004 • 45 citations

Specificity of notification for tuberculosis among screened refugees in NSW

1999 • 7 citations