Active transport of imatinib into and out of cells: implications for drug resistance

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia

2003 • 3,532 citations

Hematologic and Cytogenetic Responses to Imatinib Mesylate in Chronic Myelogenous Leukemia

2002 • 2,056 citations

The Biology of Chronic Myeloid Leukemia

1999 • 1,308 citations

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

2012 • 1,196 citations

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

1996 • 1,080 citations

Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy

2002 • 923 citations

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1999 • 911 citations

MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening

1999 • 895 citations

Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance

2000 • 789 citations

The Role of ABC Transporters in Clinical Practice

2003 • 782 citations

Mechanisms of Autoinhibition and STI-571/Imatinib Resistance Revealed by Mutagenesis of BCR-ABL

2003 • 624 citations

MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models

2003 • 554 citations

The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

2000 • 528 citations

Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification

2000 • 511 citations

Multidrug resistance transporters and modulation

2000 • 388 citations

In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABL Kinase Inhibitor

1999 • 388 citations

Role of alpha1 Acid Glycoprotein in the In Vivo Resistance of Human BCR-ABL+ Leukemic Cells to the Abl Inhibitor STI571

2000 • 332 citations

ORGANIC CATION TRANSPORTERS IN INTESTINE, KIDNEY, LIVER, AND BRAIN

1998 • 312 citations

P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate

2004 • 310 citations

Structure of renal organic anion and cation transporters

2000 • 296 citations

Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3

2002 • 279 citations

Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters

2001 • 276 citations

Distribution of STI-571 to the Brain Is Limited by P-Glycoprotein-Mediated Efflux

2002 • 269 citations

STI571 (Gleevec™) as a paradigm for cancer therapy

2002 • 244 citations

Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport

2000 • 212 citations

Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1

2002 • 209 citations

Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.

1995 • 207 citations

Simultaneous Activity of MRP1 and Pgp Is Correlated With In Vitro Resistance to Daunorubicin and With In Vivo Resistance in Adult Acute Myeloid Leukemia

1999 • 181 citations

Analysis of the Structural Basis of Specificity of Inhibition of the Abl Kinase by STI571

2002 • 171 citations

Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).

1998 • 170 citations

Interaction of Imatinib Mesilate with Human P-Glycoprotein

2003 • 161 citations

MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia

2002 • 116 citations

Transporters and xenobiotic disposition

2002 • 92 citations

Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro

2003 • 86 citations

Mutation in the ATP-binding pocket of the ABL kinase domain in an STI571-resistant BCR/ABL-positive cell line.

2002 • 78 citations

Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells

2003 • 77 citations

BCR/ABL amplification in chronic myelocytic leukemia blast crisis following imatinib mesylate administration

2002 • 76 citations

Reversal of typical multidrug resistance by cyclosporin and its non-immunosuppressive analogue SDZ PSC 833 in Chinese hamster ovary cells expressing themdr1 phenotype

1992 • 66 citations

Induction of Multidrug Resistance-1 and Cytochrome P450 mRNAs in Human Mononuclear Cells by Rifampin

2002 • 59 citations

Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias

2002 • 56 citations

Energy Dependent Transport of Xenobiotics and Its Relevance to Multidrug Resistance

2003 • 41 citations

Effects of modulators of multidrug resistance on the expression of the MDR1 gene in human KB cells in culture

1996 • 24 citations

Expression of P-glycoprotein, multidrug-resistance proteins 1 and 2 in CEM, CEMVBL, CEME1000, MDCKIIMRP1 and MDCKIIMRP2 cell lines

2003 • 7 citations