ORGANIC CATION TRANSPORTERS IN INTESTINE, KIDNEY, LIVER, AND BRAIN

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

POLYAMINES

1984 • 2,996 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Their use in investigating some properties of d-glucose and choline transport systems

1978 • 1,145 citations

A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport

1993 • 939 citations

Drug excretion mediated by a new prototype of polyspecific transporter

1994 • 637 citations

Cloning and Characterization of Two Human Polyspecific Organic Cation Transporters

1997 • 628 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

HIGH AFFINITY TRANSPORT OF CHOLINE INTO SYNAPTOSOMES OF RAT BRAIN¹

1973 • 585 citations

Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard

1970 • 546 citations

Expression cloning of a rat liver Na(+)-independent organic anion transporter.

1994 • 535 citations

A fluorescent indicator for measuring cytosolic free magnesium

1989 • 527 citations

Mechanism of Transport and Storage of Neurotransmitter

1987 • 471 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

1995 • 419 citations

Molecular Physiology of Norepinephrine and Serotonin Transporters

1994 • 404 citations

Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver.

1984 • 393 citations

Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport

1995 • 385 citations

High affinity choline transport and acetylCoA production in brain and their roles in the regulation of acetylcholine synthesis

1979 • 360 citations

cDNA Cloning and Functional Expression of a Novel Rat Kidney Organic Cation Transporter, OCT2

1996 • 353 citations

Polyamine transport in mammalian cells. An update

1996 • 341 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Choline: High-Affinity Uptake by Rat Brain Synaptosomes

1972 • 282 citations

Molecular Cloning and Characterization of NKT, a Gene Product Related to the Organic Cation Transporter Family That Is Almost Exclusively Expressed in the Kidney

1997 • 256 citations

CARRIER MEDIATED BLOOD‐BRAIN BARRIER TRANSPORT OF CHOLINE AND CERTAIN CHOLINE ANALOGS

1978 • 223 citations

Molecular cloning and characterization of a novel liver-specific transport protein

1994 • 216 citations

Electrogenic Properties and Substrate Specificity of the Polyspecific Rat Cation Transporter rOCT1

1996 • 203 citations

Primary Structure and Functional Expression of the Apical Organic Cation Transporter from Kidney Epithelial LLC-PK1Cells

1997 • 193 citations

Immunologic distribution of an organic anion transport protein in rat liver and kidney

1996 • 182 citations

Intracellular putrescine and spermidine deprivation induces increased uptake of the natural polyamines and methylglyoxal bis(guanylhydrazone)

1980 • 182 citations

Specificity of transporters for ‘organic anions’ and ‘organic cations’ in the kidney

1994 • 172 citations

Carrier-mediated transport systems of tetraethylammonium in rat renal brush-border and basolateral membrane vesicles

1984 • 167 citations

Mechanisms of active H+ secretion in the proximal tubule

1983 • 162 citations

Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver.

1996 • 152 citations

The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa

1992 • 143 citations

mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies.

1992 • 141 citations

Dopamine and norepinephrine uptake and metabolism by astroglial cells in culture

1981 • 124 citations

Transport of organic ions in renal cortical luminal and antiluminal membrane vesicles.

1979 • 118 citations

Carrier-mediated transport of ouabain in isolated hepatocytes.

1978 • 116 citations

Mechanisms of organic cation transport in kidney plasma membrane vesicles: 2. delta pH studies.

1981 • 115 citations

Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1

1996 • 107 citations

Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney.

1993 • 107 citations

The Extraneuronal Uptake and Metabolism of Catecholamines

1988 • 104 citations

Digoxin-cyclosporin A interaction: modulation of the multidrug transporter P-glycoprotein in the kidney.

1993 • 94 citations

Transport of small organic cations in the rat liver

1996 • 91 citations

Thiamine transport across the rat intestine. I. Normal characteristics.

1975 • 89 citations

Stimulation of proximal small intestinal mucosal growth by luminal polyamines

1991 • 89 citations

Kinetics of thiamine transport across the blood‐brain barrier in the rat.

1982 • 88 citations

Active transport of quaternary ammonium compounds into bile

1963 • 87 citations

Luminal and basolateral polyamine uptake by rat small intestine stimulated to grow by Phaseolus vulgaris lectin phytohaemagglutinin in vivo

1990 • 86 citations

Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems

1993 • 86 citations

Thiamine Transport Across the Rat Intestine

1975 • 74 citations

RELATIVE IMPORTANCE OF CHOLINE TRANSPORT TO SPONTANEOUS AND POTASSIUM DEPOLARIZED RELEASE OF ACh

1975 • 73 citations

The Lxl gene maps to mouse Chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters

1996 • 72 citations

Contraluminal transport of organic cations in the proximal tubule of the rat kidney

1991 • 71 citations

Transport of tetraethylammonium by rabbit renal brush-border and basolateral membrane vesicles

1987 • 68 citations

Na-H exchange regulates intracellular pH in isolated rat hepatocyte couplets

1987 • 66 citations

Structure-pharmacokinetics relationship of quaternary ammonium compounds

1984 • 66 citations

TRANSPORT AND METABOLISM OF THIAMINE IN RAT BRAIN CORTEX IN VITRO

1965 • 65 citations

Neurotransmitter transporters A novel family of integral plasma membrane proteins

1992 • 65 citations

Mechanisms of organic cation transport in kidney plasma membrane vesicles: 1. Countertransport studies.

1980 • 64 citations

Hepatobiliary elimination of cationic drugs: the role of P-glycoproteins and other ATP-dependent transporters

1997 • 64 citations

Regulation of plasma choline by the renal tubule: bidirectional transport of choline

1973 • 62 citations

Secretion of tetraethylammonium by proximal tubules of rabbit kidneys

1983 • 62 citations

A choline transporter in renal brush-border membrane vesicles: Energetics and structural specificity

1992 • 62 citations

H+ gradient-dependent transport of aminocephalosporins in rat renal brush border membrane vesicles: role of H+/organic cation antiport system.

1985 • 59 citations

Cimetidine transport in rat renal brush border and basolateral membrane vesicles

1985 • 57 citations

Daunomycin secretion by killfish renal proximal tubules

1995 • 53 citations

Transport of thiamine by brush‐border membrane vesicles from rat small intestine.

1988 • 52 citations

Regulation by protein kinase C of the contraluminal transport system for organic cations in rabbit kidney S2 proximal tubules.

1994 • 52 citations

Characteristics of putrescine uptake in isolated rat enterocytes

1988 • 52 citations

Interaction between intestinal absorption and secretion of monoquaternary ammonium compounds in guinea pigs--a concept for the absorption kinetics of organic cations.

1980 • 52 citations

The incorporation of choline into isolated synaptosomal and synaptic vesicle fractions in the presence of quaternary ammonium compounds

1971 • 51 citations

Identification, characterization, and molecular cloning of a novel transporter‐like protein localized to the central nervous system

1992 • 51 citations

Absorption and secretion of monoquaternary ammonium compounds by the isolated intestinal mucosa

1977 • 50 citations

Hormonal and Feedback Regulation of Putrescine and Spermidine Transport in Human Breast Cancer Cells

1995 • 50 citations

Structure-pharmacokinetics relationship of quaternary ammonium compounds

1984 • 49 citations

In vivo and in vitro evidence for a common carrier mediated transport of choline and basic drugs through the blood-brain barrier.

1990 • 49 citations

Ontogenic expression of the Na+-independent organic anion transporting polypeptide (oatp) in rat liver and kidney

1996 • 47 citations

Inorganic Cation Dependence of Putrescine and Spermidine Transport in Human Breast Cancer Cells

1995 • 47 citations

Luminal transport system for H+/organic cations in the rat proximal tubule

1995 • 46 citations

Electroneutral transport of organic cations in canine renal brush border membrane vesicles (BBMV).

1985 • 45 citations

Transport and metabolism of thiamin in isolated rat hepatocytes.

1979 • 45 citations

Organic cation transport by rat liver plasma membrane vesicles: studies with tetraethylammonium

1992 • 44 citations

Transport of guanidine in rabbit intestinal brush-border membrane vesicles

1988 • 44 citations

Transport of N1-methylnicotinamide across brush border membrane vesicles from rabbit kidney

1985 • 43 citations

Mechanisms for the hepatic uptake of organic cations. Studies with the muscle relaxant vecuronium in isolated rat hepatocytes.

1988 • 43 citations

Some properties of the thiamine uptake system in isolated rat hepatocytes

1984 • 42 citations

Expression of the extraneuronal monoamine transporter (uptake2) in human glioma cells

1996 • 42 citations

A multispecific uptake system for taurocholate, cardiac glycosides and cationic drugs in the liver

1992 • 41 citations

Procainamide transport in rabbit renal cortical brush border membrane vesicles

1985 • 41 citations

Carrier-mediated transport system for choline and its related quaternary ammonium compounds on rat intestinal brush-border membrane

1992 • 40 citations

Renal secretion of vinblastine, vincristine and colchicine in vivo.

1994 • 40 citations

Structure and interaction of inhibitors with the TEA/H+ exchanger of rabbit renal brush border membranes

1995 • 39 citations

Uptake characteristics of polyamines into rat intestinal brush-border membrane

1992 • 39 citations

Tetraethylammonium transport in renal brush border membrane vesicles of the rabbit.

1987 • 39 citations

Characteristics of spermidine uptake by isolated rat enterocytes

1989 • 38 citations

Organic cation transport in human renal brush-border membrane vesicles

1991 • 38 citations

Heterogeneity of organic base secretion by proximal tubules

1982 • 37 citations

Nervous tissue thiamine metabolism in vivo. I. Transport of thiamine and thiamine monophosphate from plasma to different brain regions of the rat

1984 • 36 citations

Kinetics of Choline Uptake into Isolated Rat Forebrain Microvessels: Evidence of Endocrine Modulation

1988 • 36 citations

Hepatic transport of mono and bisquaternary ammonium compounds

1970 • 35 citations

Cimetidine transport in isolated luminal membrane vesicles from rabbit kidney

1987 • 35 citations

Mechanisms for the uptake of cationic drugs by the liver: a study with tributylmethylammonium (TBuMA).

1991 • 35 citations

Spermine uptake by rat intestinal brush-border membrane vesicles

1991 • 34 citations

Imaging of reconstituted biological channels at molecular resolution by atomic force microscopy

1993 • 33 citations

Luminal transport system for choline+ in relation to the other organic cation transport systems in the rat proximal tubule

1996 • 33 citations

Bidirectional renal tubular transport of free choline: a micropuncture study

1979 • 33 citations

Sodium‐independent transport of noradrenaline in mouse and rat astrocytes in primary culture

1989 • 32 citations

MPP+ is transported by the TEA(+)-H+ exchanger of renal brush-border membrane vesicles

1990 • 31 citations

Transport of N1-methylnicotinamide by organic cation-proton exchange in rat liver membrane vesicles

1990 • 30 citations

Renal tubular transport and metabolism of organic cations by the rabbit

1981 • 30 citations

Sodium permeability of frog skeletal muscle in absence and presence of veratridine

1987 • 28 citations

Ouabain‐Sensitive Choline Transport System in Capillaries Isolated from Bovine Brain

1992 • 27 citations

Choline transport in collecting duct cells isolated from the rat renal inner medulla

1990 • 25 citations

The High-Affinity Choline Uptake System

1988 • 25 citations

Characterization of univectorial polyamine transport in duodenal crypt cell line

1993 • 23 citations

The diversity of Na+-independent uptake systems for polyamines in rat intestinal brush-border membrane vesicles

1993 • 22 citations

Cimetidine transport in rabbit renal cortical brush-border membrane vesicles

1987 • 22 citations

The transport mechanisms of organic cations and their zwitterionic derivatives across rat intestinal brush-border membrane. II. Comparison of the membrane potential effect on the uptake by membrane vesicles

1993 • 22 citations

Thiamine transport by basolateral rat liver plasma membrane vesicles

1992 • 21 citations

The inhibitory effect of choline and other quaternary ammonium compounds on thiamine transport in isolated rat hepatocytes

1985 • 18 citations

Transport and steady-state accumulation of putrescine in brush-border membrane vesicles of rabbit small intestine

1995 • 18 citations

Tetraethylammonium transport by isolated perfused snake renal tubules

1984 • 18 citations

Stop-flow analysis of the renal excretion of tritium-labeled dihydromorphine.

1965 • 15 citations

Uptake of cholic acid by freshly isolated rat hepatocytes: Presence of a common carrier for bile acid transports

1982 • 15 citations

Characteristics of tetraethylammonium transport in rabbit renal plasma-membrane vesicles

1989 • 15 citations

Uptake of quaternary ammonium compounds into rat intestinal brush border membrane vesicles

1981 • 14 citations

Roct1, a rat polyspecific transporter gene for the excretion of cationic drugs, maps to Chromosome 1q11-12

1996 • 12 citations

Kinetic study of the tubular dopamine outward transporter in the rat and dog kidney

1993 • 12 citations

Transport Mechanism of Choline in Rat Renal Brush-Border Membrane.

1993 • 11 citations

Effect of procainamide on renal tubular transport of cimetidine in the isolated perfused rat kidney

1989 • 10 citations

Sulfhydryl groups are essential for organic cation exchange in rabbit renal basolateral membrane vesicles.

1991 • 10 citations

Characteristics of putrescine uptake by human brush border membrane vesicles.

1992 • 8 citations

Specificity of basolateral organic cation transport in snake renal proximal tubules

1996 • 6 citations

ATP-DEPENDENT TRANSPORT OF AMPHIPHILIC CATIONS ACROSS THE CANALICULAR MEMBRANE MEDIATED BY P-GLYCOPROTEIN

1994 • 3 citations