Src-like Adaptor Protein (Slap) Is a Negative Regulator of T Cell Receptor Signaling

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

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Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

LAT

1998 • 1,251 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

The when and how of Src regulation

1993 • 543 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

1996 • 324 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.

1995 • 272 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

Structure of the regulatory domains of the Src-family tyrosine kinase Lck

1994 • 247 citations

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.

1996 • 194 citations

Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes.

1994 • 180 citations

A Functional T-Cell Receptor Signaling Pathway Is Required for p95^vav Activity

1995 • 173 citations

PEST sequences are signals for rapid intracellular proteolysis.

1990 • 166 citations

Calcium signalling in T cells stimulated by a cyclophilin B-binding protein

1994 • 162 citations

Reversible palmitoylation of the protein-tyrosine kinase p56lck.

1993 • 159 citations

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

1993 • 142 citations

A Model System for Activation-Induced Alternative Splicing of CD45 Pre-mRNA in T Cells Implicates Protein Kinase C and Ras

2000 • 141 citations

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.

1995 • 130 citations

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.

1990 • 129 citations

Characterization of a Novel Src-like Adapter Protein That Associates with the Eck Receptor Tyrosine Kinase

1995 • 127 citations

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit.

1995 • 98 citations

SH2 Domain Function Is Essential for the Role of the Lck Tyrosine Kinase in T Cell Receptor Signal Transduction

1996 • 92 citations

The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2.

1996 • 84 citations

c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1.

1996 • 81 citations

LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck.

1995 • 80 citations

The Ras GTPase-activating Protein (GAP) Is an SH3 Domain-binding Protein and Substrate for the Src-related Tyrosine Kinase, Hck

1995 • 79 citations

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling

1999 • 79 citations

Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein.

1994 • 77 citations

The Src and Csk families of tyrosine protein kinases in hemopoietic cells

1995 • 75 citations

Src-like adaptor protein (Slap) is a negative regulator of mitogenesis

1998 • 67 citations

Palmitylation of an Amino-Terminal Cysteine Motif of Protein Tyrosine Kinases p56^lckand p59^fynMediates Interaction With Glycosyl-Phosphatidylinositol-Anchored Proteins

1993 • 66 citations

Activation of p56^lck through Mutation of a Regulatory CarboxyTerminal Tyrosine Residue Requires Intact Sites of Autophosphorylation and Myristylation

1990 • 38 citations

Phosphatidylinositol (PI) 3-Kinase and PI 4-Kinase Binding to the CD4-p56^lck Complex: the p56^lck SH3 Domain Binds to PI 3-Kinase but Not PI 4-Kinase

1993 • 27 citations