Regulation of B cell function by linker proteins

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

1997 • 625 citations

BLNK

1998 • 501 citations

Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes

1999 • 450 citations

GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING

1999 • 432 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

1998 • 397 citations

Identification of Rap1 as a Target for the Crk SH3 Domain-Binding Guanine Nucleotide-Releasing Factor C3G

1995 • 359 citations

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral

1998 • 337 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

The complexity of signaling pathways activated by the BCR

1997 • 333 citations

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.

1993 • 318 citations

BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells

1999 • 313 citations

Requirement for B Cell Linker Protein (BLNK) in B Cell Development

1999 • 298 citations

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1997 • 285 citations

Functional and Physical Interactions of Syk Family Kinases with the Vav Proto-Oncogene Product

1996 • 281 citations

SLP-65: A New Signaling Component in B Lymphocytes which Requires Expression of the Antigen Receptor for Phosphorylation

1998 • 271 citations

Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

1998 • 268 citations

Regulation of the TRP Ca2+ Channel by INAD in Drosophila Photoreceptors

1996 • 256 citations

Phospholipase C-γ1 Interacts with Conserved Phosphotyrosyl Residues in the Linker Region of Syk and Is a Substrate for Syk

1996 • 230 citations

Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ/CD3 Induction of Interleukin-2

1997 • 224 citations

Inhibitory Pathways Triggered by ITIM-Containing Receptors

1999 • 220 citations

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

1998 • 220 citations

The Inositol Polyphosphate 5-Phosphatase Ship Is a Crucial Negative Regulator of B Cell Antigen Receptor Signaling

1998 • 212 citations

Identification of the SH2 Domain Binding Protein of Bruton’s Tyrosine Kinase as BLNK—Functional Significance of Btk-SH2 Domain in B-Cell Antigen Receptor-Coupled Calcium Signaling

1999 • 199 citations

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

1996 • 194 citations

CD19 as a Membrane-Anchored Adaptor Protein of B Lymphocytes: Costimulation of Lipid and Protein Kinases by Recruitment of Vav

1998 • 179 citations

Qualitative Regulation of B Cell Antigen Receptor Signaling by CD19: Selective Requirement for PI3-Kinase Activation, Inositol-1,4,5-Trisphosphate Production and Ca2+ Mobilization

1997 • 172 citations

B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein.

1994 • 169 citations

Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex

1994 • 167 citations

CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19.

1997 • 148 citations

BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius.

1998 • 146 citations

Role of TCR ζ Chain in T Cell Development and Selection

1994 • 141 citations

The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

1999 • 137 citations

Phosphorylation of CD19 Y484 and Y515, and Linked Activation of Phosphatidylinositol 3-Kinase, Are Required for B Cell Antigen Receptor-Mediated Activation of Bruton’s Tyrosine Kinase

1999 • 126 citations

The Dynamics of Protein Kinase B Regulation during B Cell Antigen Receptor Engagement

1999 • 124 citations

The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1

1998 • 121 citations

Expression of Dominant-Negative Src-Homology Domain 2-Containing Protein Tyrosine Phosphatase-1 Results in Increased Syk Tyrosine Kinase Activity and B Cell Activation

1999 • 111 citations

Cutting Edge: BASH, A Novel Signaling Molecule Preferentially Expressed in B Cells of the Bursa of Fabricius

1998 • 109 citations

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

1999 • 98 citations

Shc Contains Two Grb2 Binding Sites Needed for Efficient Formation of Complexes with SOS in B Lymphocytes

1997 • 94 citations

Tyrosine Phosphorylation of Shc Is Mediated through Lyn and Syk in B Cell Receptor Signaling

1995 • 93 citations

The Gab1 Protein Is a Docking Site for Multiple Proteins Involved in Signaling by the B Cell Antigen Receptor

1998 • 93 citations

Distinct Signal Thresholds for the Unique Antigen Receptor–Linked Gene Expression Programs in Mature and Immature B Cells

1999 • 89 citations

The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase

2000 • 89 citations

B cell antigen receptor stimulation induces formation of a Shc-Grb2 complex containing multiple tyrosine-phosphorylated proteins.

1994 • 89 citations

Co-receptors on B lymphocytes

1999 • 72 citations

Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs.

1998 • 70 citations

Inhibition of Signaling Through the B Cell Antigen Receptor by the Protooncogene Product, c-Cbl, Requires Syk Tyrosine 317 and the c-Cbl Phosphotyrosine-Binding Domain

1999 • 67 citations

Analysis of Tyrosine Phosphorylation-dependent Interactions between Stimulatory Effector Proteins and the B Cell Co-receptor CD22

1999 • 66 citations

FcγRIIb Modulation of Surface Immunoglobulin-induced Akt Activation in Murine B Cells

1999 • 64 citations

The Src Homology Domain 2-Containing Inositol Phosphatase SHIP Forms a Ternary Complex with Shc and Grb2 in Antigen Receptor-stimulated B Lymphocytes

1999 • 64 citations

Regulation of TCR Signal Transduction in Murine Thymocytes by Multiple TCR ζ-Chain Signaling Motifs

1998 • 60 citations

Reconstitution of B Cell Antigen Receptor-induced Signaling Events in a Nonlymphoid Cell Line by Expressing the Syk Protein-tyrosine Kinase

1996 • 57 citations

Identification of Two Tyrosine Phosphoproteins, pp70 and pp68, Which Interact with Phospholipase Cγ, Grb2, and Vav after B Cell Antigen Receptor Activation

1997 • 51 citations

CD72-mediated B cell activation involves recruitment of CD19 and activation of phosphatidylinositol 3-kinase

1998 • 43 citations

Distinct mechanisms mediate SHC association with the activated and resting B cell antigen receptor

1996 • 42 citations

Convergence of CD19 and B Cell Antigen Receptor Signals at MEK1 in the ERK2 Activation Cascade

1998 • 41 citations

Analysis of murine CD22 during B cell development: CD22 is expressed on B cell progenitors prior to IgM

1997 • 40 citations

Receptor Modulators of B-Cell Receptor Signalling — CD19/CD22

2000 • 31 citations

B-Cell Antigen Receptor Signaling in Immature-Stage B Cells: Integrating Intrinsic and Extrinsic Signals

2000 • 27 citations

SHP-1 deficiency in B-lineage cells is associated with heightened lyn protein expression and increased lyn kinase activity.

1998 • 20 citations

Tyrosine Phosphorylation of Shc in Response to B Cell Antigen Receptor Engagement Depends on the SHIP Inositol Phosphatase

1999 • 16 citations

bca: an activation-related B-cell gene

1998 • 11 citations

bca: an activation-related B-cell gene

1998 • 3 citations