Association of interleukin-1 alpha gene polymorphism with cerebral infarction

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

The changing landscape of ischaemic brain injury mechanisms

1999 • 1,111 citations

Inflammation and glial responses in ischemic brain lesions

1998 • 788 citations

Interleukin 1 in the brain: biology, pathology and therapeutic target

2000 • 673 citations

Increased Proinflammatory Cytokines in Patients With Chronic Stable Angina and Their Reduction By Aspirin

1999 • 585 citations

Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats

1995 • 572 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

Neuroprotective Effects of Human Recombinant Interleukin-1 Receptor Antagonist in Focal Cerebral Ischaemia in the Rat

1996 • 456 citations

Association of interleukin-1 gene polymorphisms with Alzheimer's disease

2000 • 358 citations

Association of early-onset Alzheimer's disease with an interleukin-1? gene polymorphism

2000 • 331 citations

A genetic association between juvenile rheumatoid arthritis and a novel interleukin‐1α polymorphism

1995 • 327 citations

Concomitant cortical expression of TNF-α and IL-1β mRNAs follows early response gene expression in transient focal ischemia

1994 • 278 citations

Attenuation of Stroke Size in Rats Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist in Brain

1995 • 245 citations

Genetics of inflammation and risk of coronary artery disease: the central role of interleukin-6

2000 • 241 citations

Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion.

1995 • 238 citations

Potential mechanisms of interleukin-1 involvement in cerebral ischaemia

1999 • 232 citations

Association of an interleukin 1α polymorphism with Alzheimer’s disease

2000 • 194 citations

Polymorphisms in Inflammatory Genes and the Risk of Alzheimer Disease

2001 • 191 citations

Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1α

2002 • 190 citations

Interleukin‐1β and the interleukin‐1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat

1998 • 168 citations

Exacerbation of Ischemic Brain Damage by Localized Striatal Injection of Interleukin-1β in the Rat

1998 • 159 citations

Inflammatory gene polymorphisms and ischaemic heart disease: review of population association studies

2002 • 155 citations

An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus

2000 • 145 citations

Cerebral vessels express interleukin 1β after focal cerebral ischemia

1998 • 125 citations

Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease

2002 • 101 citations

Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat

2000 • 91 citations

Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease

2000 • 88 citations

Interleukin-1 receptor antagonist attenuates the heat stroke-induced neuronal damage by reducing the cerebral ischemia in rats

1995 • 86 citations

Attenuation of Ischemic Inflammatory Response in Mouse Brain Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist

1998 • 80 citations

Rate of cognitive decline in AD is accelerated by the interleukin-1α −889 *1 allele

2001 • 49 citations

A study of interleukin-1 cluster genes in susceptibility to and severity of multiple sclerosis

2001 • 42 citations

Middle cerebral artery occlusion in the rat causes a biphasic production of immunoreactive interleukin-1β in the cerebral cortex

1998 • 38 citations